Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has a molecular...
14 KB (1,616 words) - 05:33, 8 February 2024
Cell growth (section Linking Cdr2 to Wee1)
balance of Wee1 and Cdc25 activity with changes in cell size is coordinated by the mitotic entry control system. It has been shown in Wee1 mutants, cells...
37 KB (4,869 words) - 09:19, 17 May 2024
employ such a mechanism, via Cdr2-mediated spatial regulation of Wee1 activity. Though Wee1 is a fairly conserved negative regulator of mitotic entry, no...
22 KB (2,818 words) - 07:39, 3 June 2024
CyclinB-Cdc2 inhibitors, Wee1 and Myt1. Cdc25 activates the complex through the removal of phosphates from the active site while Wee1 inactivates the complex...
18 KB (2,231 words) - 00:00, 17 March 2024
phase, the CDK1 subunit of MPF is inactive due to an inhibitory enzyme, Wee1. Wee1 phosphorylates the Tyr-15 residue of CDK1, rendering MPF inactive. During...
6 KB (873 words) - 07:41, 3 June 2024
based on early studies on TKIs aiming at VEGF receptors. Adavosertib is a Wee1 kinase inhibitor that is undergoing numerous clinical trials in the treatment...
9 KB (1,081 words) - 04:46, 16 June 2022
then phosphorylates and inhibits Wee1, also recruited to the medial node by the presence of Cdr2. The phosphorylated Wee1 allows Cdc25 to dephosphorylate...
8 KB (972 words) - 15:57, 6 December 2018
WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene. This gene encodes a nuclear protein, which is a...
8 KB (1,028 words) - 10:21, 27 November 2023
Pee Wee Crayton, singer WEE virus, the western equine encephalitis virus Wee1, a nuclear protein In the Wee Small Hours, album of Frank Sinatra In the...
2 KB (239 words) - 23:06, 8 April 2024
drug candidate. It is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. It is being developed...
4 KB (285 words) - 12:00, 24 January 2024
and reaches the G2/M transition, the kinase Plk1 phosphorylates Wee1, which targets Wee1 for degradation via the SCF ubiquitin ligase complex. An additional...
34 KB (4,581 words) - 11:50, 4 April 2024
Pom1 inhibits Cdr2, preventing Cdr2 and Cdr1 from inhibiting Wee1, and allowing Wee1 to phosphorylate Cdk1, thus inactivating cyclin-dependent kinase...
52 KB (6,047 words) - 17:48, 24 May 2024
controlled by the balance between WEE1 kinases, Myt1 kinases, and the phosphorylation of Cdc25c phosphatases. Wee1, a kinase preserved across all eukaryotes...
35 KB (3,829 words) - 14:24, 17 June 2024
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase...
46 KB (5,492 words) - 03:05, 21 June 2024
non-essential. Cdr2 regulates mitotic entry through direct inhibition of Wee1, which is then unable to continue to Cdk1 and subsequently start mitosis...
5 KB (672 words) - 16:29, 12 September 2023
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase...
65 KB (7,147 words) - 05:41, 24 June 2024
doi:10.1038/nrd2871. PMID 19629074. S2CID 7817325. "Clinical trials using WEE1 inhibitor AZD1775". National Cancer Institute. Retrieved April 20, 2018....
23 KB (742 words) - 04:57, 30 December 2023
to stabilization of this phosphorylation, preventing mitotic progression. Wee1, conserved among all eukaryotes phosphorylates Tyr15, whereas members of...
24 KB (2,875 words) - 23:48, 3 December 2023
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase...
3 KB (296 words) - 17:06, 14 September 2023
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase...
14 KB (1,210 words) - 13:35, 14 June 2024
Myc, E2f1, p130 cyclin-dependent kinase inhibitors (CKIs): p27Kip1, p21, Wee1 centriole proteins: Cep250, Ninein There are approximately seventy human...
16 KB (2,021 words) - 19:31, 28 January 2023
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase...
119 KB (12,654 words) - 16:07, 28 May 2024
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase...
45 KB (4,670 words) - 00:07, 2 June 2024
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase...
49 KB (5,394 words) - 05:41, 13 June 2024
phosphorylation at non-glycine residues within this motif, making this site subject to Wee1 and/or Myt1 inhibitory kinase phosphorylation and Cdc25 de-phosphorylation...
18 KB (2,258 words) - 22:16, 16 December 2023
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase...
27 KB (2,665 words) - 17:03, 6 April 2024
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase...
57 KB (6,278 words) - 05:05, 3 June 2024
that in humans is encoded by the PKMYT1 gene. Myt 1 is an enzyme in the Wee1 family and found in vertebrates. The Wee 1 family includes a variety of...
12 KB (1,609 words) - 20:28, 25 May 2024
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase...
35 KB (3,831 words) - 00:20, 19 July 2024
January 2013, Maris co-authored Combination Therapy Targeting the Chk1 and Wee1 Kinases Shows Therapeutic Efficacy in Neuroblastoma which was a combination...
7 KB (599 words) - 01:55, 12 September 2023