The 3C-like protease (3CLpro) or main protease (Mpro), formally known as C30 endopeptidase or 3-chymotrypsin-like protease, is the main protease found...

antiviral medication developed by Pfizer which acts as an orally active 3C-like protease inhibitor. It is part of a nirmatrelvir/ritonavir combination used...

COVID-19. It is a combination of nirmatrelvir, a protease inhibitor targeted to the SARS-CoV-2 3C-like protease, and ritonavir, which inhibits the metabolism...

trypsin-like cysteine protease, calicivirus TCP, calicivirus 3C-like protease, calicivirus endopeptidase, rabbit hemorrhagic disease virus 3C endopeptidase)...

eukaryotes. A characteristic of the group is a conserved 3C-like protease from the PA clan of proteases for processing the translated polyprotein. The name...

Papain-like proteases (or papain-like (cysteine) peptidases; abbreviated PLP or PLCP) are a large protein family of cysteine protease enzymes that share...

into six smaller non-structural proteins (NS1/2 to NS7) by the viral 3C-like protease (NS6), a major structural protein (VP1) of about 58~60 kDa and a minor...

functioning new viral proteins. They are particularly interested in proteases such as 3C-like protease (Mpro), a coronavirus nonstructural protein that mediates...

which was discovered in the 1960s. The molecule is an inhibitor of the 3C-like protease of SARS-CoV-1 and SARS-CoV-2. Sarpogrelate Ketanserin Ritanserin Neuman...

proteins within the polyprotein. A second protease also encoded by ORF1a, called the 3C-like protease or main protease, is responsible for the majority of further...

RG (January 2006). "Treating HCV with ribavirin analogues and ribavirin-like molecules". The Journal of Antimicrobial Chemotherapy. 57 (1): 8–13. doi:10...

; Meadows, J. M.; Chang, K. O. (13 September 2017). "Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis"...

partnership with Hokkaido University and acts as an orally active 3C-like protease inhibitor. It is taken by mouth. The most common adverse events include...

Kankanamalage AC, Eckstrand C, Groutas WC, et al. (April 2018). "Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis"...

on cannabinoids it was found that 11-OH-Δ9-THC had the 3rd highest 3C-like protease inhibitor activity against COVID-19 out of all the cannabinoids tested...

Picornain 3C (EC 3.4.22.28) is a protease found in picornaviruses, which cleaves peptide bonds of non-terminal sequences. Picornain 3C’s endopeptidase...

is a member of the PA clan of chymotrypsin-like proteases. Due to its high sequence specificity, TEV protease is frequently used for the controlled cleavage...

The total number of deaths attributed to the virus was 6,881,955. 3C-like protease (NS5) Solodovnikov A, Arkhipova V (29 July 2021). "Достоверно красиво:...

attached to the 5'-end of the genome and a conserved 3C-like protease from the PA clan of proteases for processing the translated polyprotein. The name...

"The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases". The Journal of Biological...

had been demonstrated in vitro. Nirmatrelvir belongs to a family of 3C-like protease inhibitors developed in the late 2010s against feline coronavirus,...

combination of ritonavir with nirmatrelvir, a newly developed orally active 3C-like protease inhibitor, was developed for the treatment of COVID-19. Ritonavir serves...

Zn-cluster binding domain fused with a helicase (HEL1); 3CLpro is a 3C-like protease; and NendoU is an uridylate-specific endonuclease. The 3CLpro has a...

Island on phytocannabinoids it was found that CBGA had the 2nd highest 3C-like protease inhibitor activity against COVID-19 out of all the phytocannabinoids...

Island on phytocannabinoids it was found that THC-Butyl had the highest 3C-like protease inhibitor activity against COVID-19 out of all the phytocannabinoids...

C-30 C30, a compact audio cassette C30 endopeptidase, also called 3C-like protease This disambiguation page lists articles associated with the same title...

partnership with Hokkaido University and acts as an orally active 3C-like protease inhibitor. It is taken by mouth. The most common adverse events include...

Articles Zhavoronkov, A., et al., "Potential non-covalent SARS-CoV-2 3C-like protease inhibitors designed using generative deep learning approaches and reviewed...

making it an attractive therapeutic target. Unlike the viral enzymes (protease, reverse transcriptase and integrase) that are currently targeted by small-molecule...

performed by two proteases: the papain-like protease protein domain located in the multidomain protein nsp3 cleaves up to nsp4, and the 3CL protease (also known...