(BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the BCR gene. BCR is one of the two genes in the BCR-ABL...
14 KB (1,541 words) - 16:10, 15 March 2024
Philadelphia chromosome (redirect from Bcr-abl fusion protein)
contains a fusion gene called BCR-ABL1. This gene is the ABL1 gene of chromosome 9 juxtaposed onto the breakpoint cluster region BCR gene of chromosome 22...
29 KB (3,538 words) - 15:01, 5 December 2023
translocation results in the head-to-tail fusion of the BCR and ABL1 genes, leading to a fusion gene present in many cases of chronic myelogenous leukemia...
30 KB (3,502 words) - 08:07, 14 August 2024
radius, a parameter of a contact lens Benzoyl-CoA reductase, an enzyme BCR (gene), the breakpoint cluster region protein Biochemical recurrence, for example...
3 KB (371 words) - 20:00, 13 May 2024
the bcr-abl fusion gene product is also a tyrosine kinase. The fused BCR-ABL protein interacts with the interleukin 3beta(c) receptor subunit. The BCR-ABL...
34 KB (3,877 words) - 13:44, 25 October 2024
tyrosine kinase gene at chromosome 9 and the break point cluster (Bcr) gene at chromosome 22, resulting in a chimeric oncogene (Bcr-Abl) and a constitutively...
56 KB (6,470 words) - 06:03, 24 October 2024
a computer program. Breakpoint or break point may also refer to: BCR (gene), the gene that encodes the breakpoint cluster region protein Break point, in...
1 KB (193 words) - 17:03, 14 August 2023
off and trade places. The ABL gene from chromosome 9 joins to the BCR gene on chromosome 22, to form the BCR-ABL fusion gene. Tyrosine kinase activity is...
43 KB (5,251 words) - 10:44, 24 June 2024
of a new BCR::ABL1 fusion gene, composed of the 3' part of the ABL1 gene in the breakpoint on chromosome 9 and the 5' part of a gene called BCR in the breakpoint...
17 KB (1,928 words) - 19:40, 5 August 2024
CD19 (redirect from CD19 (gene))
tightly regulated through B cell receptor (BCR) interactions and signaling. The presence of a functional BCR is necessary during antigen-dependent differentiation...
32 KB (3,916 words) - 10:07, 6 October 2024
Abr, rhogef and gtpase activating protein (category Genes on human chromosome 17)
Region (BCR) gene located on chromosome 22 and has shown to share similar protein functions. Additionally, the protein encoded by this gene contains...
5 KB (549 words) - 16:45, 14 September 2024
Terminal deoxynucleotidyl transferase (redirect from DNTT (gene))
adds N-nucleotides to the V, D, and J exons of the TCR and BCR genes during antibody gene recombination, enabling the phenomenon of junctional diversity...
30 KB (3,557 words) - 05:39, 17 August 2024
Antibody (redirect from Immunoglobulin gene)
hypermutation, class switching, and affinity maturation targeting the BCR gene loci, but on occasion more unconventional forms of diversification have...
121 KB (13,516 words) - 08:01, 2 November 2024
viability. HRS cells also express the virus's LMP2A gene protein product which mimics the human BCR gene product) in promoting the survival of its parent...
140 KB (16,977 words) - 09:07, 9 September 2024
leukemia, a neoplasm commonly caused by a mutation that creates the BCR-ABL1 fusion gene (see Philadelphia chromosome). The disease is due to conversion of...
48 KB (5,760 words) - 23:15, 2 December 2023
crisis. The cells are non-adherent and rounded, are positive for the bcr:abl fusion gene, and bear some proteomic resemblance to both undifferentiated granulocytes...
11 KB (1,386 words) - 21:28, 12 August 2023
The B-cell receptor (BCR) is a transmembrane protein on the surface of a B cell. A B-cell receptor is composed of a membrane-bound immunoglobulin molecule...
18 KB (2,173 words) - 16:05, 30 November 2023
different genes. Naturally occurring fusion proteins are commonly found in cancer cells, where they may function as oncoproteins. The bcr-abl fusion...
19 KB (2,305 words) - 05:22, 15 May 2024
Exosome component 2 (redirect from EXOSC2 (gene))
"Structural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating...
8 KB (1,045 words) - 03:28, 26 February 2024
FBXW4 (redirect from FBXW4 (gene))
pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. GRCh38: Ensembl release 89: ENSG00000107829 – Ensembl...
7 KB (866 words) - 03:47, 1 April 2024
GRB2 (redirect from GRB2 (gene))
gene, Arachidonate 5-lipoxygenase, B-cell linker, BCAR1, BCR gene, Beta-2 adrenergic receptor, C-Met, CBLB, CD117, CD22, CD28, CDKN1B, CRK, Cbl gene,...
82 KB (9,365 words) - 15:39, 31 March 2024
Tyrosine-protein kinase Fes/Fps (redirect from FES (gene))
identified. Feline sarcoma oncogene has been shown to interact with BCAR1 and BCR gene. GRCh38: Ensembl release 89: ENSG00000182511 – Ensembl, May 2017 GRCm38:...
5 KB (577 words) - 13:48, 14 August 2023
SOS1 (redirect from SOS1 (gene))
SOS1 activators (e.g. VUBI1). SOS1 has been shown to interact with: ABI1, BCR gene, CRK, EPS8, Epidermal growth factor receptor, FRS2, Grb2, HRAS, ITSN1,...
32 KB (3,595 words) - 10:04, 27 March 2024
2020. Japp, Alberto (4 February 2021). "TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes"...
23 KB (2,445 words) - 18:22, 18 August 2024
cells and natural killer cells, express B cell receptors (BCRs) on their cell membrane. BCRs allow the B cell to bind to a foreign antigen, against which...
32 KB (3,748 words) - 21:03, 6 November 2024
PTPN6 (redirect from PTPN6 (gene))
hematopoietic cells decreases in cancer. PTPN6 has been shown to interact with: BCR gene, CD117, CD22, CD31, CTNND1, EGFR, EPOR, FCRL3, Grb2, HOXA10, JAK2, LAIR1...
20 KB (2,292 words) - 02:56, 28 March 2024
VAV1 (redirect from VAV1 (gene))
proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization". Oncogene. 7 (4):...
17 KB (1,999 words) - 06:15, 25 December 2023
CD79A (redirect from CD79A (gene))
membrane-bound immunoglobulin in B-cells, thus forming the B-cell antigen receptor (BCR). This occurs in a similar manner to the association of CD3 with the T-cell...
19 KB (2,434 words) - 07:18, 15 October 2024
hepatosplenomegaly, and the absence of the Philadelphia chromosome or a BCR/ABL fusion gene. The most common clinical finding is hepatosplenomegaly. Pruritus...
6 KB (585 words) - 01:09, 29 February 2024