receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. FLT3 is a cytokine receptor which...

ligand (FLT3LG) is a protein which in humans is encoded by the FLT3LG gene. Flt3 ligand (FL) is a hematopoietic four helical bundle cytokine. It is structurally...

the brand name Xospata, is an anti-cancer drug. It acts as an inhibitor of FLT3, hence it is a tyrosine kinase inhibitor. It was developed by Astellas Pharma...

for oncogenic FLT3, in combination with chemotherapy. The drug is approved for use with a companion diagnostic, the LeukoStrat CDx FLT3 Mutation Assay...

tyrosine kinase inhibitor. Its molecular target is FLT3, also known as CD135 which is a proto-oncogene. FLT3 mutations are among the most common mutations...

and CSF1R also belong to this receptor class. FLT3 protein binds and is activated by the FLT3 ligand; FLT3 protein activation involves its forming dimers...

to FLT3-ITD, FLT3-D835H and FLT3-D835Y with Kd of 0.74 nM, 0.4 nM, and 0.18 nM, respectively. Crenolanib inhibits the phosphorylation of the FLT3-ITD...

future. FLT3 internal tandem duplications (ITDs) have been shown to confer a poorer prognosis in AML with normal cytogenetics. Several FLT3 inhibitors...

of cancer. It is an inhibitor of the kinases fms-like tyrosine kinase 3 (FLT3), Janus kinase 2 (JAK2), tropomyosin receptor kinase (trk) A (TrkA), TrkB...

inhibitor (TKI) of c-Met (HGFR) and VEGFR2, and also inhibits AXL, RET, and FLT3. It was discovered and developed by Exelixis Inc. In November 2012, cabozantinib...

2020. "VANFLYTA (quizartinib), FDA Approved in the U.S. for Newly Diagnosed FLT3-ITD Positive Acute Myeloid Leukemia, Available at Biologics by McKesson |...

risk stratification model. IPSS-M determined that multihit TP53 mutations, FLT3 mutations, and partial tandem duplication mutations of KMT2A (MLL) were strong...

and FLT3. Abu-Duhier FM, Goodeve AC, Care RS, et al. (February 2003). "Mutational analysis of class III receptor tyrosine kinases (C-KIT, C-FMS, FLT3) in...

cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), FLT3-ITD positive AML and radioactive iodine resistant advanced thyroid carcinoma...

mainly inhibits Janus kinase 2 (JAK2) and Fms-like tyrosine kinase 3\CD135 (FLT3). Common side effects include diarrhea, low platelet counts, nausea, anemia...

common dendritic cell progenitors expressing Flt3 (CD135) receptors are able to give rise to pDCs. Flt3 or CD135 signaling induces differentiation and...

cells] in murine cultures show phenotypic markers as being CD34-, CD150+, and Flt3- for LTR [long-term reconstitution]. These phenotypic markers are used when...

inhibitor targeting multiple tyrosine kinases such as CSF1R, ABL, c-KIT, FLT3, and PDGFR-β. Specifically, it is used for chronic myelogenous leukemia (CML)...

the t(8;21) because 70% of t(6;9) acute myeloid leukemia patients have the FLT3-ITD mutation (Schwartz et al., 1983, Kottaridis, 2001). The FLT-ITD mutation...

3; vascular endothelial growth factor receptor (VEGFR) 1, 2, and 3; and FLT3. Its use in IPF is predicated on its inhibition of PDGFR, FGFR, and VEGFR...

Trial). The inhibitor targets multiple kinase pathways, including BTK and FLT3. Bruton's tyrosine kinase is named for Ogden Bruton, who first described...

FLT3 interacting zinc finger 1 is a protein that in humans is encoded by the FIZ1 gene. This gene encodes zinc finger protein, which interacts with a receptor...

expression of markers such as CD150 and FMS-related tyrosine kinase 3 (FLT3), into CD150+ FLT3-hematopoietic stem cells (HSCs) and CD150- FLT3low multipotent...

FCRL2 FCRL3 FCRL4 FCRL5 FCRL6 FCRLA FGFR1 FGFR2 FGFR3 FGFR4 FGFRL1 FLT1 FLT3 FLT4 FSTL4 FSTL5 GP6 GPA33 GPR116 GPR125 HEPACAM HLA-DMA HLA-DMB HLA-DQB...

PMID 10837469. PDB: 1ETE​; Savvides SN, Boone T, Andrew Karplus P (June 2000). "Flt3 ligand structure and unexpected commonalities of helical bundles and cystine...

[citation needed] The initial treatment with for example BCL2-inhibitors, FLT3-inhibitors, or IDH1/2-inhibitors, may kill leukemic cells. However, pre-leukemic...

inhibitor of MET and several other receptor tyrosine kinases such as MST1R, FLT3, AXL, MERTK, TEK, ROS1, NTRK1/2/3, and DDR1/2. Meristinib is part of a phase...

mice by clonal cells expanded from single CD34+CD38- cells expressing Flk2/Flt3". British Journal of Haematology. 119 (2): 525–534. doi:10.1046/j.1365-2141...

EPHB6; ERBB2; ERBB3; ERBB4; FER; FES; FGFR1; FGFR2; FGFR3; FGFR4; FGR; FLT1; FLT3; FLT4; FRK; FYN; GSG2; HCK; IGF1R; ILK; INSR; INSRR; IRAK4; ITK; JAK1; JAK2;...

the disease himself. His team used genetic sequencing and noticed that the FLT3 gene was hyperactive in his leukemia cells and used sunitinib as a treatment...