• The FriedelCrafts reactions are a set of reactions developed by Charles Friedel and James Crafts in 1877 to attach substituents to an aromatic ring....
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  • sulfonation, alkylation FriedelCrafts reaction and acylation FriedelCrafts reaction. The most widely practised example of this reaction is the ethylation...
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  • Thumbnail for Aluminium chloride
    as a catalyst in Friedel-Crafts alkylation and related reactions. AlCl3 is a common Lewis-acid catalyst for Friedel-Crafts reactions, both acylations...
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  • Thumbnail for James Crafts
    Mason Crafts (March 8, 1839 – June 20, 1917) was an American chemist, mostly known for developing the FriedelCrafts alkylation and acylation reactions with...
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  • for the German chemist Ludwig Gattermann and is similar to the FriedelCrafts reaction. Modifications have shown that it is possible to use sodium cyanide...
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  • Thumbnail for Acetyl chloride
    ketene. A second major class of acetylation reactions are the Friedel-Crafts reactions. Acetic acid Acetyl bromide Acetyl fluoride Acetyl iodide Merck...
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  • Thumbnail for Charles Friedel
    and mineralogy at the Sorbonne. Friedel developed the Friedel-Crafts alkylation and acylation reactions with James Crafts in 1877, and attempted to make...
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  • Thumbnail for 1-Tetralone
    3-Benzoylpropanoic acid itself can be obtained by a Haworth reaction (a variant of the Friedel-Crafts reaction) from benzene and succinic anhydride. The intramolecular...
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  • Lewis acid catalysis (category Chemical reactions)
    reactions involving carbon–carbon or carbon–heteroatom bond formation can be catalyzed by Lewis acids. Examples include the Friedel-Crafts reaction,...
    45 KB (5,026 words) - 04:16, 15 October 2024
  • Thumbnail for Alkylation
    Alkylation (category Organic reactions)
    Amberlyst, or Lewis acids like aluminium. On a laboratory scale the FriedelCrafts reaction uses alkyl halides, as these are often easier to handle than their...
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  • for the Friedel–Crafts reaction Georges Friedel (1865–1933), French crystallographer and mineralogist; son of Charles Edmond Friedel (1895–1972), French...
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  • 2-tert-butylpyridine. The reaction resembles Friedel-Crafts alkylation but with opposite reactivity and selectivity. The Minisci reaction often produces a mixture...
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  • Thumbnail for Zincke–Suhl reaction
    reaction is a special case of a Friedel-Crafts alkylation and was first described by Theodor Zincke and Suhl in 1906. Unlike the traditional Friedel-Crafts...
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  • Thumbnail for One-pot synthesis
    is introduced (red). The enolate reacts as an electrophile in a Friedel-Crafts reaction with ring-closure. The alcohol group is eliminated in presence...
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  • Thumbnail for Dibenzofuran
    transfer agent. It undergoes electrophilic reactions, such as halogenation and Friedel-Crafts reactions. Reaction of DBF with butyl lithium results in dilithiation...
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  • for the Friedel-Crafts reaction Georges Friedel (1865–1933), French crystallographer and mineralogist; son of Charles Edmond Friedel (1895–1972), French...
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  • Thumbnail for Trisoxazolines
    Zheng-Zheng; Tang, Yong (1 February 2004). "Controllable Enantioselective FriedelCrafts Reaction between Indoles and Alkylidene Malonates Catalyzed by Pseudo-C3-Symmetric...
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  • Thumbnail for Leaving group
    Leaving group (category Reaction mechanisms)
    in the Friedel-Crafts reaction. Here, a strong Lewis acid is required to generate either a carbocation from an alkyl halide in the Friedel-Crafts alkylation...
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  • prepared from phthalic anhydride and benzene derivatives through a Friedel-Crafts reaction. Intermediate Compounds: Key intermediates are needed to ensure...
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  • derivatives used for SHJ reactions should be purified, dried, and powdered before use. Intramolecular Friedel-Crafts reaction of the aromatic ring of a...
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  • condensation, the FriedelCrafts acylation, and the Diels–Alder reaction. Books have been published devoted exclusively to name reactions; the Merck Index...
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  • Thumbnail for Triphenylmethane
    (C6H5CHCl2, Benzylenchlorid). Triphenylmethane can be synthesized by FriedelCrafts reaction from benzene and chloroform with aluminium chloride catalyst: 3...
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  • Thumbnail for Stoichiometry
    stoichiometry. For example, the methylation of benzene (C6H6), through a FriedelCrafts reaction using AlCl3 as a catalyst, may produce singly methylated (C6H5CH3)...
    35 KB (5,274 words) - 17:51, 16 September 2024
  • Ferrocene (section Reactions)
    undergoes substitution reactions rather than addition reactions on the cyclopentadienyl ligands. For example, Friedel-Crafts acylation of ferrocene with...
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  • Thumbnail for Sulfone
    resulting sulfolene. Sulfones are prepared under conditions used for FriedelCrafts reactions using sources of RSO+ 2 derived from sulfonyl halides and sulfonic...
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  • Library. "4.10: Alkylation and Acylation of Aromatic Rings - The Friedel-Crafts Reaction". Chemistry LibreTexts. 2020-06-21. Retrieved 2024-02-07. Wiberg;...
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  • Thumbnail for Anthraquinone
    oxidant. The Friedel-Crafts reaction of benzene and phthalic anhydride in presence of AlCl3. o-Benzoylbenzoic acid is an intermediate. This reaction is useful...
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  • Thumbnail for Formylation
    Gattermann reaction and Gattermann-Koch reaction. These involve strong acid catalysis and proceed in a manner similar to the FriedelCrafts reaction. Hydroformylation...
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  • aryl-alkyl ketones, such as those formed in a Friedel-Crafts acylation. The two-step sequence of Friedel-Crafts acylation followed by Clemmensen reduction...
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  • Thumbnail for Cyclopentyl methyl ether
    (alcohols and amines) Lewis acids-mediated reactions: Beckmann Reaction, Friedel-Crafts Reaction etc. Reactions using Organometallic reagents or basic agents:...
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