known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene. The...

Docking proteins such as GRB2 contain an SH2 domain that binds to the phosphotyrosine residues of the activated receptor. GRB2 binds to the guanine nucleotide...

GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene. GAB2 is a docking protein with a conserved...

GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene. The protein encoded by this gene is a member of the IRS1-like...

GRB2 associated binding protein 3 is a protein that in humans is encoded by the GAB3 gene. This gene is a member of the GRB2-associated binding protein...

substrate 2 GAB2 – GRB2-associated binding protein 2 GRAP – GRB2-related adaptor protein GRAP2 – GRB2-related adaptor protein 2 GRB2 – Growth factor receptor-bound...

found on Grb2 proteins, allowing them to bind Receptor Tyrosine Kinases (RTKs), and also on SOS proteins allowing them to interact with Grb2. This brings...

adaptor protein Grb2 forms a complex with Sos by the Grb2 SH3 domain. Grb2 (or the Grb2/Sos complex) is recruited to the membrane by the Grb2 SH2 domain binding...

unable to bind PI3K but is able to bind Grb2 and Gads, gives little NF-κB or IL-2, suggesting that those Grb2 and Gads are unable to compensate for the...

Adenylyl cyclase Phospholipase C Phospholipase A guanylate cyclase RasGEF (Grb2-Sos) Second messenger cAMP (cyclic adenosine monophosphate) IP3; DAG; Ca2+...

less clear. HER2/neu has been shown to interact with: CTNNB1, DLG4, Erbin, GRB2, HSP90AA1, IL6ST, MUC1, PICK1 and PIK3R2, PLCG1, and SHC1. SkBr3 Cell Line...

vera. Janus kinase 2 has been shown to interact with: DNAJA3 EGFR EPOR FYN Grb2 GHR IRS1 IL12RB2 IL5RA PIK3R1 PPP2R4 PTK2 PTPN11 PTPN6 PRMT5 SH2B1 SHC1 SOCS3...

GRB2-related adapter protein 2 also known as GRB2-related adaptor downstream of Shc (GADS) is a 37 kDa protein that in humans is encoded by the GRAP2...

with: ABI1, BCR gene, CRK, EPS8, Epidermal growth factor receptor, FRS2, Grb2, HRAS, ITSN1, MUC1, NCK1, PLCG1, PTPN11, SH3KBP1, and SHC1. and Son of Sevenless...

typically activated by growth hormones through receptor tyrosine kinases and GRB2/SOS, but may also receive other signals. ERKs are known to activate many...

CAV1, CAV3, CBL, CBLB, CBLC, CD44, CDC25A, CRK, CTNNB1, DCN, EGF, GRB14, Grb2, JAK2, MUC1, NCK1, NCK2 PKC alpha, PLCG1, PLSCR1, PTPN1, PTPN11, PTPN6, PTPRK...

protein called growth factor-receptor bound protein-2 (Grb2) along with a docking protein called Grb2-associated Binder-1 (GAB1). Subsequently, phosphatidylinositol-3...

protein tyrosine kinases and the growth factor receptor bound protein 2 (Grb2). Phosphotyrosine-binding (PTB) domain PTB domains interact with sequences...

BCR protein has been shown to interact with: Abl gene, CD117, CRKL FES, Grb2, GRB10, HCK, MLLT4, PXN, PIK3CG, PTPN6, PTPRT(PTPrho) SOS1, and XPB. Abl...

to interact with: APS, BCR, CD63, CD81, CD9, CRK, CRKL, DOK1, FES, GRB10, Grb2, KITLG, LNK, LYN, MATK, MPDZ, PIK3R1, PTPN11, PTPN6, STAT1, SOCS1, SOCS6...

transduction CtBP Yes Transcription factor FIP2 Not known Cell morphogenesis Grb2 Not known Growth factor receptor binding protein HAP1 Yes Membrane trafficking...

pathway, is recruited by the adaptor protein GRB2 in response to EGF receptor activation. The binding of SOS1 to GRB2 localizes it to the plasma membrane, where...

SH3-containing GRB2-like protein 3-interacting protein 1 is a protein that in humans is encoded by the SGIP1 gene. GRCh38: Ensembl release 89: ENSG00000118473...

Beta-2 adrenergic receptor has been shown to interact with: AKAP12, OPRD1, Grb2, SNX27 and SLC9A3R1. Other adrenergic receptors Alpha-1 adrenergic receptor...

GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene. This gene encodes a member of the GRB2/Sem5 (C. elegans homolog)/Drk...

insulin-regulated genes. First, the protein Grb2 binds the P-Tyr residue of IRS-1 in its SH2 domain. Grb2 is then able to bind SOS, which in turn catalyzes...

bind the LAT/Slp76 complex include: Phospholipase Cγ1 (PLCγ1), SOS via a Grb2 adaptor, Itk, Vav, Nck1 and Fyb. PLCγ is a very important enzyme in the pathway...

phosphorylate itself. The phosphorylated receptor binds to an adaptor protein (GRB2), which couples the signal to further downstream signaling processes. For...

receptor for NGF, p75NTR. TrkA has been shown to interact with: Abl gene, FRS2, Grb2, MATK, NGFB, PLCG1, RICS, SQSTM1, SH2B1, SH2B2, and SHC1. Small molecules...

signalling, called Grb2, has an SH2 domain, and therefore it can bind to receptors phosphorylated by JAKs (in a similar way to PI3K). Grb2 then functions...