HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western...
9 KB (697 words) - 02:42, 27 January 2024
HLA DR3-DQ2 is a double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype. Certain HLA DR and DQ...
51 KB (5,010 words) - 20:40, 4 July 2024
HLA A1-B8-DR3-DQ2 haplotype (Also: AH8.1, COX, Super B8, ancestral MHC 8.1 or 8.1 ancestral haplotype) is a multigene haplotype that covers a majority...
39 KB (4,876 words) - 01:13, 1 June 2024
a large number of diseases. This haplotype, HLA A1-B8-DR3-DQ2, is associated with diseases in which HLA-DQ2 has suspect involvement. Direct involvement...
33 KB (3,380 words) - 17:14, 6 July 2024
Human leukocyte antigen (redirect from HLA antigen)
The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation...
51 KB (5,942 words) - 15:58, 25 September 2024
HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR (Human...
31 KB (2,293 words) - 12:25, 28 December 2023
"Type 1 diabetes risk for HLA-DR3 haplotypes depends on genotypic context: Association of DPB1 and HLA class I loci among DR3 and DR4 matched Italian patients...
19 KB (1,618 words) - 16:26, 3 March 2024
HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of moderate frequency alleles...
26 KB (2,119 words) - 03:34, 29 November 2023
Sardinia). DR17 is part of the broader antigen group HLA-DR3 and is very similar to the group HLA-DR18. DR17 recognizes the DRB1*0301, *0304 alleles. DR17...
13 KB (1,088 words) - 07:38, 22 December 2023
prevalent after age 60. Some cases are inherited, and HLA subtypes HLA-DR3, HLA-DR52, and HLA-DR6 seem to create a disposition to autoimmune dermatomyositis...
29 KB (2,761 words) - 07:59, 27 July 2024
HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among centenarians. The serology for the...
20 KB (1,596 words) - 01:46, 28 November 2023
HLA A30-Cw5-B18-DR3-DQ2 (A30::DQ2) is a multigene haplotype that extends across a majority of the major histocompatibility complex on human chromosome...
38 KB (4,047 words) - 01:13, 1 June 2024
Major histocompatibility complex (section HLA biology)
In humans, each HLA allele is named with a number. For instance, for a given individual, his haplotype might be HLA-A2, HLA-B5, HLA-DR3, etc... Each heterozygous...
58 KB (6,785 words) - 20:25, 21 September 2024
HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 broad antigen. DQ8 is determined...
67 KB (5,460 words) - 15:43, 3 July 2024
immune response. Anti-Ro/SSA associates with the HLA II alleles HLA-DR3 and HLA-DR2, as well as some HLA-DQ alleles. The T-cell response plays a role in...
14 KB (1,783 words) - 03:28, 12 August 2023
HLA class II histocompatibility antigen, DR alpha chain is a protein that in humans is encoded by the HLA-DRA gene. HLA-DRA encodes the alpha subunit...
9 KB (1,145 words) - 03:20, 25 December 2023
genetic variations that seem to predispose them to these diseases. HLA-DR3-B8 (an HLA subtype), in particular, seems to predispose to LEMS. In normal neuromuscular...
19 KB (2,244 words) - 15:12, 25 September 2024
HLA A1-B8 (Also:HL A1,8; HL A1,A8; HLA A1-Cw7-B8; HLA A*01-B*08, HLA A*0101-B*0801, HLA A*0101-Cw*0701-B*0801; HLA A*01:01-C*07:01-B*08:01) is a multigene...
23 KB (2,540 words) - 15:48, 3 July 2024
associated. In nonpersistent disease, a strong genetic association exists with HLA DR3-DQ2. Cardiac sarcoid has been connected to tumor necrosis factor alpha...
118 KB (12,860 words) - 03:15, 27 August 2024
HLA class II histocompatibility antigen, DRB3-1 beta chain is a protein that in humans is encoded by the HLA-DRB3 gene. The protein encoded by this gene...
9 KB (1,108 words) - 23:50, 12 August 2023
called HLA-DR3 and HLA-DR4-HLA-DQ8, and are common in people of European descent. A pattern associated with reduced risk of type 1 diabetes is called HLA-DR15-HLA-DQ6...
95 KB (10,829 words) - 18:52, 21 September 2024
DM Type 1. HLA DR3 is correlated strongly with Sjögren syndrome, myasthenia gravis, lupus erythematosus, and type 1 diabetes mellitus. HLA DR4 is correlated...
50 KB (5,851 words) - 16:28, 29 July 2024
association of early-onset, severe disease with the HLA-DR3 serotype and late-onset disease with the HLA-DR4 serotype. The diagnosis of autoimmune hepatitis...
35 KB (3,762 words) - 08:32, 6 July 2024
HLA-B8 (B8) is an HLA-B serotype. The serotype identifies the HLA-B*08 gene products. (For terminology help see: HLA-serotype tutorial) HLA-B8, previously...
10 KB (220 words) - 14:47, 26 June 2024
tumor necrosis factor-2 allele, human leukocyte antigen (HLA) B8, HLA Cw7, HLA DR3, and HLA DQ2. While it is acknowledged that one of the hallmarks of...
32 KB (3,187 words) - 08:37, 22 August 2024
P, Bogner U, Finke R, Meinhold H, Koppenhagen K, Wenzel K (1983). "HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse...
8 KB (695 words) - 18:06, 4 December 2023
Saarinen S, Mitchell S, Broomé U, Chapman R, Olerup O (August 2001). "The HLA-DR3,DQ2 heterozygous genotype is associated with an accelerated progression...
24 KB (1,460 words) - 02:42, 27 January 2024
setting of autoimmune polyendocrine syndromes (APS), mutations in AIRE or HLA-DR3/4 can contribute to its pathology. There is no set mechanism specifically...
11 KB (1,255 words) - 19:04, 3 June 2024
antibodies and most will have interstitial lung disease, HLA-DR3 and HLA-DRw52 human leukocyte antigen (HLA) markers; collectively known as Jo-1 syndrome. Anti-double...
54 KB (6,097 words) - 21:43, 28 June 2024
avenin-sensitive enteropathy (ASE). All three patients were the DQ2.5/DQ2 (HLA DR3-DQ2/DR7-DQ2) phenotype. Patients with DQ2.5/DQ2.2 tend to be the most prone...
15 KB (1,966 words) - 00:47, 23 August 2023