Inosine 5′-monophosphate dehydrogenase (IMPDH) is a purine biosynthetic enzyme that catalyzes the nicotinamide adenine dinucleotide (NAD+)-dependent oxidation...

recent decades. Inosine monophosphate is oxidised by the enzyme inosine monophosphate dehydrogenase, yielding xanthosine monophosphate, a key precursor...

non-competitive, selective, and reversible inhibitor of inosine-5′-monophosphate dehydrogenase (IMPDH), which is a key enzyme in the de novo guanosine...

Inosine-5'-monophosphate dehydrogenase 1, also known as IMP dehydrogenase 1, is an enzyme that in humans is encoded by the IMPDH1 gene. IMP dehydrogenase...

during pregnancy may harm the baby. It works by blocking inosine monophosphate dehydrogenase (IMPDH), which is needed by lymphocytes to make guanosine...

Inosine-5'-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an enzyme that in humans is encoded by the IMPDH2 gene. IMP dehydrogenase...

are also found in a wide variety of other proteins such as inosine monophosphate dehydrogenase, voltage gated chloride channels and AMP-activated protein...

et al. (1997). "Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex". Biochemistry. 36 (35):...

and Sequence Analysis of the Human and Chinese Hamster Inosine-5'-monophosphate Dehydrogenase cDNA" (PDF). The Journal of Biological Chemistry. 263 (30):...

C-N bond of a 5'-AMP to replace the carboxyl group forming 5'-IMP. 5'-IMP is then catalyzed by Inosine-5'-monophosphate dehydrogenase (IMPDH) in guanine...

e. bases attached to ribose 5-phosphate. Both adenine and guanine are derived from the nucleotide inosine monophosphate (IMP), which is the first compound...

classified as purines. In purine synthesis, PRPP is turned into inosine monophosphate, or IMP. Production of IMP from PRPP requires glutamine, glycine...

never a DNA nucleoside mimic. Ribavirin 5'-monophosphate inhibits cellular inosine monophosphate dehydrogenase, thereby depleting intracellular pools of...

the conversion of IMP to GMP involves two enzymes. First, inosine monophosphate dehydrogenase (IMPDH) catalyzes the conversion of IMP to XMP; then GMP...

[citation needed] Mycophenolic acid Mycophenolic acid is an inosine-5′-monophosphate dehydrogenase (IMPDH)-inhibitor. It enhances abacavir but reduces the...

its activity through selective inhibition of inosine monophosphate dehydrogenase and guanosine monophosphate synthetase, resulting in the complete inhibition...

"Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH) – the major therapeutic target". Curr. Med. Chem...

nucleotide, from inosine monophosphate (IMP or inosinate). It consists of two structural genes guaB (encodes for IMP dehydrogenase or and guaA (encodes...

malaria. In the 1970s, Allison had worked out the enzyme, inosine monophosphate dehydrogenase, as a key molecule of the immune response in autoimmune diseases...

be synthesized de novo, with the rate-limiting enzyme of inosine monophosphate dehydrogenase. The word guanine derives from the Spanish loanword guano...

and guanine for the enzyme HGPRT and is itself converted to thio inosine monophosphate (TIMP). TIMP inhibits several chemical reactions involving inosinic...

synthesis of guanine nucleotides via the enzyme Inosine monophosphate dehydrogenase (IMP dehydrogenase), leading to DNA mutations. TGMP is converted by...

vivo. IMPDH is a rate limiting enzyme that catalyses IMP to xanthosine monophosphate (XMP). It can induce meiotic resumption as XMP produced is ultimately...

exercise-induced; inosine, hypoxanthine and uric acid increase in plasma after exercise and decrease over hours with rest. Excess AMP (adenosine monophosphate) is converted...

exercise-induced; inosine, hypoxanthine and uric acid increase in plasma after exercise and decrease over hours with rest. Excess AMP (adenosine monophosphate) is converted...

synthesized by converting phosphoribosyl pyrophosphate (PRPP) to inosine monophosphate (IMP), which is the first key intermediate in purine base biosynthesis...

dihydroorotase". "Entrez Gene: DHODH dihydroorotate dehydrogenase". "Entrez Gene: UMPS uridine monophosphate synthetase". "Entrez Gene: UCK2 uridine-cytidine...

(VX-497) is a drug which acts as an inhibitor of the enzyme inosine monophosphate dehydrogenase, which is required for the synthesis of nucleotide bases...

statins, local nitrates or iloprost Digital ulcers with phosphodiesterase 5 inhibitors (e.g., sildenafil) or iloprost Prevention of new digital ulcers...

purine nucleotide cycle, three nucleotides: AMP (adenosine monophosphate), IMP (inosine monophosphate), and S-AMP (adenylosuccinate) are converted in a circular...