Interleukin 21 (IL-21) is a protein that in humans is encoded by the IL21 gene. Interleukin-21 is a cytokine that has potent regulatory effects on cells...
23 KB (2,936 words) - 15:14, 9 April 2024
Interleukin 11 (IL-11 or adipogenesis inhibitory factor) is a protein that in humans is encoded by the IL11 gene. IL-11 is a cytokine that was first isolated...
22 KB (2,508 words) - 16:48, 29 July 2024
Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene. The protein encoded by this gene is a cytokine receptor for interleukin...
10 KB (864 words) - 16:12, 28 October 2022
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes)...
45 KB (4,194 words) - 12:36, 2 May 2024
Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and...
26 KB (3,305 words) - 17:31, 8 August 2024
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid...
14 KB (1,578 words) - 14:00, 26 February 2024
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the...
63 KB (7,473 words) - 02:17, 23 July 2024
Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. They are produced by a group of T helper cell known as T helper...
35 KB (3,989 words) - 13:32, 13 July 2024
Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin 5...
13 KB (1,523 words) - 19:27, 26 June 2024
Common gamma chain (redirect from Interleukin-2 receptor gamma chain)
receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. The γc glycoprotein is a member...
16 KB (2,092 words) - 14:33, 22 June 2024
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit...
20 KB (2,192 words) - 23:02, 27 November 2023
The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to...
49 KB (6,005 words) - 16:30, 10 June 2024
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5–16 kDa protein that regulates the activities...
43 KB (5,000 words) - 13:28, 1 July 2024
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells...
19 KB (2,293 words) - 11:05, 8 March 2024
Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells,...
22 KB (2,834 words) - 11:07, 29 July 2024
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is...
40 KB (4,858 words) - 14:50, 21 July 2024
Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone...
13 KB (1,675 words) - 00:18, 14 December 2023
ankylosing spondylitis, and psoriatic arthritis. It binds to the protein interleukin (IL)-17A and is marketed by Novartis. Secukinumab is used to treat psoriasis...
15 KB (1,153 words) - 05:27, 18 July 2024
Anti-interleukin-6 agents are a class of therapeutics. Interleukin 6 is a cytokine relevant to many inflammatory diseases and many cancers. Hence, anti-IL6...
12 KB (1,289 words) - 19:20, 4 December 2023
two subunits of the cytokine Interleukin-23. Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an Interleukin 23 alpha subunit and an IL-12p40...
11 KB (1,358 words) - 17:09, 6 September 2023
The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene. IL-1RA was initially called the IL-1 inhibitor...
12 KB (1,315 words) - 19:57, 6 May 2024
Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with...
24 KB (3,043 words) - 22:14, 16 June 2024
Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene. The protein encoded by...
18 KB (2,082 words) - 08:54, 18 March 2024
Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2...
39 KB (4,458 words) - 06:59, 3 June 2024
Interleukin-17A is a protein that in humans is encoded by the IL17A gene. In rodents, IL-17A used to be referred to as CTLA8, after the similarity with...
53 KB (6,247 words) - 19:58, 2 April 2024
Type I cytokine receptor (redirect from Type 1 interleukin receptors)
receptor Interleukin-12 receptor Interleukin-13 receptor Interleukin-15 receptor Interleukin-18 receptor Interleukin-21 receptor Interleukin-23 receptor...
5 KB (514 words) - 18:29, 7 June 2023
Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene. Interleukin 33 is a member of the IL-1 family that potently drives production...
25 KB (3,015 words) - 07:17, 1 August 2024
Interleukin-1 alpha (IL-1 alpha) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene. In...
22 KB (2,691 words) - 01:32, 15 March 2024
Interleukin-22 (IL-22) is a protein that in humans is encoded by the IL22 gene. IL-22 is an α-helical cytokine. IL-22 binds to a heterodimeric cell surface...
17 KB (1,945 words) - 13:34, 9 July 2024
form of a humanized monoclonal antibody. The substance acts by binding interleukin 17A and neutralizing it, reducing inflammation. The most common side...
16 KB (1,451 words) - 18:24, 2 August 2024