are homozygous for that allele). A detailed explanation of how knockout (KO) mice are created is located at the website of the Nobel Prize in Physiology...

shown postnatally comparing KO mice and controls, where both cell number and cortical thickness was decreased in KO mice. Using a cell staining methodology...

greater response in βarr2-KO mice. Moreover, the inhibition of N-methyltransferase blocks 5-HTP-induced head twitches in βarr2-KO mice, indicating that N-methyltryptamines...

these KO mice is that they have a very restricted phenotype: Casp3, 9, APAF-1 KO mice have deformations of neural tissue and FADD and Casp 8 KO showed...

MMP-3 WT and KO mice, MMP-3 was shown to increase BSCB permeability, with the WT mice showing greater BSCB permeability than the KO mice after spinal...

mice and MT1 knock-out (KO) mice were given melatonin and their rates of entrainment were observed. Entrainment was observed to accelerate in WT mice...

for male fertility in mice. TRPV6 KO mice or mice expressing loss-of-function version of TRPV6 channel (Trpv6D541A homozygous mice) have a severely impaired...

PMC 3043074. PMID 21364941. Bernardet M, Crusio WE (September 2006). "Fmr1 KO mice as a possible model of autistic features". TheScientificWorldJournal. 6:...

of the β2-nAChR-KO mice is also controversial as there has been some evidence that correlated firing still occurs in the knock-out mice, as detailed in...

the formation of pentamers as opposed to hexamers. In J chain-knockout (KO) mice, the hexameric IgM polymer dominates. These J chain negative IgM hexamers...

expansion of T cells. HDAC9 KO mice are shown to suffer from cardiac hypertrophy which is exacerbated in mice that are double KO for HDACs 9 and 5. The Class...

pathways has been demonstrated using mice. In contrast to NmU peptide-deficient mice, NmUR2 knockout (KO) mice appeared normal with regard to stress...

KO mice. Therefore, MAP6 KO mice serve as useful models for the treatment and pathophysiology of schizophrenia. In addition to schizophrenia, MAP6 KO...

homozygous mice were routinely compared to control mice, age and sex-matched heterozygous Pah-KO mice that expressed sufficient PAH enzyme activity to supply...

effects on trafficking of other receptors, as those mice are almost identical to AM KO mice and mice lacking the Calcitonin-like receptor which are unable...

embryonically lethal and mice with BMAL1 ablated in adulthood do not express the symptoms of BMAL1 KO mice. A recent study finds that BMAL1 KO mice exhibit autistic-like...

hyperactivity in mice.42 This effect was found to be DAT-independent, since suppression of hyperactivity was observed in DAT-KO mice.42 The collected...

the ventromedial hypothalamus (Inui, 1999; Horvath, 2003). CB1 knockout (KO) mice showed higher levels of CRH mRNA, suggesting that hypothalamic EC receptors...

DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice". Aging Cell. 16 (1): 52–60. doi:10.1111/acel.12525. PMC 5242303. PMID 27618784...

hyperactivity in mice.42 This effect was found to be DAT-independent, since suppression of hyperactivity was observed in DAT-KO mice.42 The collected...

apoptosis, metastasis, inflammation, and fibrosis. The Thy-1 knockout (KO) mice are viable and appear grossly normal. They display normal social interactions...

DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice". Aging Cell. 16 (1): 52–60. doi:10.1111/acel.12525. PMC 5242303. PMID 27618784...

firing rate of DA neurons in the brain slice of VTA from WT mice but not from TAAR1-KO mice. EPPTB also prevented TAAR1 agonist p-tyramine (p-try)-induced...

markers for the cells of both enterocytic and secretory lineages. Jak3 KO mice showed reduced expression of colonic villin, carbonic anhydrase, secretory...

from ICSBP knockout (KO) mice, as revealed by lack of CD11clowB220+Ly6C+CD11b− cells. In parallel, CD11c+ cells isolated from ICSBP KO spleens were unable...

KO show an increase in spine density. Long term potentiation in CA1 neurons was not observed in HDAC2 OE mice but was easily induced in HDAC2 KO mice...

statistically significant changes in osmotic erythrocyte fragility in TAAR5-KO mice. Mutations in the TAAR5 gene were found to affect human olfaction. Icelanders...

O; Briault S (2014). "Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule". Orphanet Journal of Rare Diseases....

CD201 knock-out (KO) mice had 40% lower arthritis incidence and 50% less disease severity compared to wild-type (WT) mice. CD201 KO mice also had significantly...

et al. (September 2015). "Generation of Evc2/Limbin global and conditional KO mice and its roles during mineralized tissue formation". Genesis. 53 (9): 612–626...