NLRP1 encodes NACHT, LRR, FIIND, CARD domain and PYD domains-containing protein 1 in humans. NLRP1 was the first protein shown to form an inflammasome...

Lausanne, in 2002. In 2002, it was first reported by Martinon et al. that NLRP1 (NLR family PYD-containing 1) could assemble and oligomerize into a structure...

activation of an inflammasome complex nucleated by innate immune sensors such as NLRP1 (nucleotide-binding oligomerization domain (NOD)-like receptors), pyrin...

NAIP NLRC (C for CARD): NOD1, NOD2, NLRC3, NLRC4, NLRC5 NLRP (P for PYD): NLRP1, NLRP2, NLRP3, NLRP4, NLRP5, NLRP6, NLRP7, NLRP8, NLRP9, NLRP10, NLRP11...

there are at least 14 different known NLRP genes in humans, which are named NLRP1 through NLRP14. The genes translate into proteins with differing lengths...

lupus erythematosus, and celiac disease. Among the inflammatory products of NLRP1 are caspase 1 and caspase 7, which activate the inflammatory cytokine interleukin-1β...

the NLRP1 protein and affects the level of activation of the NLRP1 inflammasome. This function involves binding to a complex of full-length NLRP1 and...

have identified mutations responsible for progeroid syndromes in humans, NLRP1 inflammasome-related diseases, self-healing cancers and numerous diseases...

domain. There are 14 members of this protein subfamily in humans (called NLRP1 to NLRP14). NLRP3 and NLRP4 are responsible for the inflammasome activation...

a mechanism triggered by increased mitochondrial membrane permeability. NLRP1 is also considered as a cytoplasmic sensor of peptidoglycan. It can sense...

some cases, where the signaling proteins contain their own CARDs, like in NLRP1 and NLRC4, the CARD–CARD interaction is direct, meaning there is no adaptor...

TLR4, CD91 ATP P2X7, P2Y2 F-actin DNGR-1 Cyclophilin A CD147 Aβ TLR2, NLRP1, NLRP3, CD36, RAGE Nuclear Histones TLR2, TLR4 HMGB1 TLR2, TLR4, RAGE HMGN1...

endopeptidase activity Cellular component cytoplasm NLRP3 inflammasome complex NLRP1 inflammasome complex AIM2 inflammasome complex nucleolus endoplasmic reticulum...

proteins containing this domain include: CIITA NAIP NLRC3, NLRC4, NLRC5 NLRP1, NLRP2, NLRP3, NLRP4, NLRP5, NLRP6, NLRP7, NLRP8, NLRP9, NLRP10, NLRP11...

syndrome, types 1, 2, 3, and 4 Neonatal onset multisystem inflammatory disease NLRP1 deficiency PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum...

until a conformational change is induced by their ligand. Some NLRs such as NLRP1 and NLRP2 have a straightforward mechanism by which the receptor binds to...

Q7RTR2 10599 NLRC4 HGNC:16412 Q9NPP4 10600 NLRC5 HGNC:29933 Q86WI3 10601 NLRP1 HGNC:14374 Q9C000 10602 NLRP2 HGNC:22948 Q9NX02 10603 NLRP2B HGNC:29887...

[31][permanent dead link] NLRC5 It has also been called NOD27, NOD4, and CLR16.1 NLRP1: NLR family, pyrin domain containing 1 (previously called NALP1) [32][permanent...

has been shown to interact with: APIP, BCL2-like 1 Caspase-9, HSPA4, and NLRP1. GRCh38: Ensembl release 89: ENSG00000120868 – Ensembl, May 2017 GRCm38:...

CARD domain) NOD1 NOD2 NLRC3 NLRC4 (IPAF) NLRC5 NLRP (P for Pyrin domain) NLRP1 NLRP2 NLRP3 NLRP4 NLRP5 NLRP6 NLRP7 NLRP8 NLRP9 NLRP10 NLRP11 NLRP12 NLRP13...

cytosolic PRRs that are known to induce inflammasome formation are NLRP3, NLRP1, NLRC4, AIM2 and Pyrin. These proteins contain oligomerization NACHT domains...

with: APAF1 BIRC2, Baculoviral IAP repeat-containing protein 3, Caspase 8, NLRP1, and XIAP. The Proteolysis Map Caspase Caspase-3 Apoptosome Apaf-1 GRCh38:...

protein containing a CARD (PYCARD) and NLR Family Pyrin Domain Containing 1 (NLRP1). Structurally, GBPs consist of two domains: a globular N- terminal domain...

positive selection. The gene with the strongest positive selection was NLRP1, which has two haplotypes undergoing selective sweeps. The first haplotype...