An oncogene is a gene that has the potential to cause cancer. In tumor cells, these genes are often mutated, or expressed at high levels. Most normal cells...
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Oncogene addiction is a process in which cancers with genetic, epigenetic, or chromosomal irregularities become dependent on one or several genes for maintenance...
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Oncogene is a peer-reviewed scientific journal published under the Springer Nature addressing cancer cell genetics and the structure and function of oncogenes...
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Myc (redirect from Proto-oncogene proteins C-myc)
Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc...
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KIT (gene) (redirect from Proto-oncogene proteins c-kit)
Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation...
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Oncovirus (redirect from Viral oncogene protein)
into the host cell or to enhance already existing oncogenic genes (proto-oncogenes) in the genome. For example, it has been shown that vFLIP and vCyclin...
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Protein kinase B (redirect from Proto-oncogene proteins c-akt)
positive regulator of cell migration. Akt1 was originally identified as the oncogene in the transforming retrovirus, AKT8. Akt2 is an important signaling molecule...
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ABL (gene) (redirect from Abl oncogene)
initially isolated from the Abelson murine leukemia virus. The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been...
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Ras GTPase (redirect from Ras oncogene)
three Ras genes in humans (HRAS, KRAS, and NRAS) are the most common oncogenes in human cancer; mutations that permanently activate Ras are found in...
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Fusion protein (redirect from Oncogene proteins, fusion)
produce a functional fusion protein. Many important cancer-promoting oncogenes are fusion genes produced in this way. Examples include: Gag-onc fusion...
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The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of extracellular...
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Hepatocyte growth factor receptor (redirect from Proto-oncogene proteins c-met)
the MET gene are associated with papillary renal carcinoma. MET proto-oncogene (GeneID: 4233) has a total length of 125,982 bp, and it is located in the...
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SPI1 (redirect from Spleen focus forming virus proviral integration oncogene spi1)
"The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors". Oncogene. 5 (5): 663–668. PMID 1693183. Oikawa T,...
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Protein c-Fos (redirect from Oncogene proteins v-fos)
Protein c-Fos is a proto-oncogene that is the human homolog of the retroviral oncogene v-fos. It is encoded in humans by the FOS gene. It was first discovered...
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C-Raf (redirect from Proto-oncogene proteins c-raf)
RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme that in humans is encoded...
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Tumor suppressor gene (redirect from Anti-oncogene)
A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. If the cell grows uncontrollably...
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ERBB4 (redirect from V-erb-a erythroblastic leukemia viral oncogene homolog 4)
(Mar 1995). "Localization of the human HER4/erbB-4 gene to chromosome 2". Oncogene. 10 (6): 1235–7. PMID 7700649. Sardi SP, Murtie J, Koirala S, Patten BA...
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KRAS (redirect from V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog)
KRAS because it was first identified as a viral oncogene in the Kirsten RAt Sarcoma virus. The oncogene identified was derived from a cellular genome,...
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Platelet-derived growth factor (redirect from Proto-oncogene proteins c-sis)
to specificity of downstream signaling. It has been shown that the sis oncogene is derived from the PDGF B-chain gene. PDGF-BB is the highest-affinity...
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ROS1 (redirect from C-ros oncogene 1)
Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene. This proto-oncogene, highly expressed in a variety...
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BOC (gene) (redirect from BOC cell adhesion associated, oncogene regulated)
BOC Identifiers Aliases BOC, CDON2, BOC cell adhesion associated, oncogene regulated, Boi External IDs OMIM: 608708; MGI: 2151153; HomoloGene: 32819; GeneCards:...
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BRAF (gene) (redirect from V-raf murine sarcoma viral oncogene homolog B1)
called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B, while the protein is more formally known...
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N-Myc (redirect from V-myc myelocytomatosis viral related oncogene)
N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene...
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Bcl-2 (redirect from Proto-oncogene proteins C-bcl-2)
cause cancer. But simultaneous over-expression of Bcl-2 and the proto-oncogene myc may produce aggressive B-cell malignancies including lymphoma. In follicular...
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Thrombopoietin receptor (redirect from Myeloproliferative leukemia virus oncogene)
humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene. In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia...
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Adapter molecule crk (redirect from V-crk sarcoma virus CT10 oncogene homolog)
Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene. The CRK protein participates in the Reelin...
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MAF (gene) (redirect from Proto-oncogene proteins c-maf)
Transcription factor Maf, also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog, is a transcription factor that in...
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Epidermal growth factor receptor (redirect from Oncogene proteins v-erbb)
myocardial fibrosis, chronic kidney disease). The identification of EGFR as an oncogene has led to the development of anticancer therapeutics directed against...
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ERBB3 (redirect from V-erb-b2 erythroblastic leukemia viral oncogene homolog 3)
extensive homology to EGF receptor shares chromosomal location with neu oncogene". Science. 230 (4730): 1132–1139. Bibcode:1985Sci...230.1132C. doi:10.1126/science...
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Tpr-met fusion protein (redirect from Oncogene protein tpr-met)
Tpr-Met fusion protein is an oncogene fusion protein consisting of TPR and MET. Tpr-Met was generated following a chromosomal rearrangement induced by...
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