Partner and localizer of BRCA2, also known as PALB2 or FANCN, is a protein which in humans is encoded by the PALB2 gene. This gene encodes a protein that functions...

FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (BRIP1), FANCL, FANCM, FANCN (PALB2), FANCO (RAD51C), FANCP (SLX4), FANCQ (XPF), FANCS (BRCA1), FANCT (UBE2T)...

the effectiveness of these therapies can be increased. BRCA1, BRCA2 and PALB2 are proteins that are important for the repair of double-strand DNA breaks...

the DNA double-strand break requires the formation of the BRCA1-PALB2-BRCA2 complex. PALB2 (Partner and localizer of BRCA2) can function synergistically...

Rutgers Cancer Institute of New Jersey, known for his discovery of the PALB2 tumor suppressor gene Marilyn Kozak, RWJMS Professor of Biochemistry, discoverer...

ovarian cancer. A recent study of the genes ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2 and TP53 found 15,311 DNA sequence variants in only 102 patients. Many of...

approximately 33% chance of developing ovarian cancer. Pathogenic variants in PALB2 – a gene whose product directly interacts with that of BRCA2 – also increase...

MAP3K3 MED17 MED21 MRE11A MSH2 MSH3 MSH6 Myc NBN NMI NPM1 NCOA2 NUFIP1 P53 PALB2 POLR2A PPP1CA Rad50 RAD51 RBBP4 RBBP7 RBBP8 RELA RB1 RBL1 RBL2 RPL31 SMARCA4...

cancer – including BRCA1, ATM, NBS1, MSH2, MSH6, PMS2, CHEK2, RAD51D, and PALB2. Additionally, variants in the genome near the oncogene MYC are associated...

ataxia-telangiectasia and autosomal dominantly inherited mutations in the BRCA2 and PALB2 genes; hereditary non-polyposis colon cancer (Lynch syndrome); and familial...

mutations in either BRCA gene. Mutations in other genes such as CHEK2, PALB2, PTEN, ATM and RAD51L3 (also termed RAD51D) have been reported to occur...

associated with ovarian cancer are BRIP1, MSH6, RAD51C and RAD51D. CDH1, CHEK2, PALB2 and RAD50 have also been associated with ovarian cancer. Several rare genetic...

these different cancers was found for DNA repair genes BRCA1, BRCA2, BARD1, PALB2, FANCC, RAD51C and RAD51D. Reduced ability to accurately repair DNA damages...

and hereditary breast cancer predisposition such as PALB2. He is a founding member of the PALB2 Interest Group. Other areas of research include hereditary...

have approximately double the normal risk of developing breast cancer. PALB2: Studies vary in their estimate of the risk from mutations in this gene...

Shahana (2017-11-01). "Rare, protein-truncating variants in ATM, CHEK2 and PALB2, but not XRCC2, are associated with increased breast cancer risks". Journal...

DNA. This protein can interact with the ssDNA-binding protein RPA, BRCA2, PALB2 and RAD52. The structural basis for Rad51 filament formation and its functional...

rare cancer syndromes. Mutations in CHECK2, ATM, NBS1, RAD50, BRIP1, and PALB2 can double the risk of breast cancer development. Biallelic mutations, in...

repair defects beyond BRCA1/2 deficiencies. These include deficiencies in PALB2, FANCD2, RAD51, ATM, MRE11, p53, XRCC1 and LSD1. ARID1A, a chromatin modifier...

phosphorylates BRCA1. Ubiquinated FANCD2 complexes with BRCA1 and RAD51. The PALB2 protein acts as a hub, bringing together BRCA1, BRCA2 and RAD51 at the site...

genes (ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, or RAD51C) were assessed prospectively using tumor tissue and/or circulating...

he directs the Xia Laboratory. He is best known for his discovery of the PALB2 tumor suppressor gene, a notable scientific advance in the field of cancer...

Mutations in other tumor suppressor genes like TP53, PTEN, CDH1, ATM, CHEK2 and PALB2, and oncogenes like KRAS, BRAF and ERBB2 have also been linked with an increased...

kits are available for human clinical diagnostics including BRCA, TP53, PALB2 and CFTR analysis. The technique has also been proven as a useful and powerful...

O96013 11670 PAK5 HGNC:15916 Q9P286 11671 PAK6 HGNC:16061 Q9NQU5 11672 PALB2 HGNC:26144 Q86YC2 11673 PALD1 HGNC:23530 Q9ULE6 11674 PALLD HGNC:17068 Q8WX93...

A, et al. (August 2019). "Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative...

recombinational repair of double-strand breaks. The major pathway depends on BRCA1, PALB2 and BRCA2 while an alternative pathway depends on RAD52. Pre-clinical studies...

PMID 12239151. S2CID 11001855. Park JY, Zhang F, Andreassen PR (2014). "PALB2: the hub of a network of tumor suppressors involved in DNA damage responses"...

identification of more moderate cancer susceptibility genes such as CHEK2, ATM and PALB2 each of which play a role in some breast cancers. He has additionally identified...

1182/blood-2002-01-0278. PMID 12239151. Park JY, Zhang F, Andreassen PR (August 2014). "PALB2: the hub of a network of tumor suppressors involved in DNA damage responses"...