Prostacyclin (also called prostaglandin I2 or PGI2) is a prostaglandin member of the eicosanoid family of lipid molecules. It inhibits platelet activation...

Prostaglandin-I synthase (EC 5.3.99.4) also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis...

The prostacyclin receptor, also termed the prostaglandin I2 receptor or just IP, is a receptor belonging to the prostaglandin (PG) group of receptors....

from the system. Prostacyclin is synthesized from arachidonic acid in endothelial cells. In vascular smooth muscle cells, prostacyclin binds mainly to...

lipoxygenase pathway. The cyclooxygenase pathway produces thromboxane, prostacyclin and prostaglandin D, E and F. Alternatively, the lipoxygenase enzyme...

conversion of arachidonic acid to prostaglandin H2, an important precursor of prostacyclin, which is expressed in inflammation. PTGS2 (COX-2), converts arachidonic...

reactions), the thromboxanes (mediators of vasoconstriction), and the prostacyclins (active in the resolution phase of inflammation). Prostanoids are seen...

blocking the action of the potent vasoconstrictor endothelin-1. Prostacyclins and prostacyclin agonists also cause vasodilation and also inhibit platelet aggregation...

biosynthesis of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family...

Korea, as a vasodilator and antiplatelet agent. It is classified as a prostacyclin analog. It has been studied for the treatment of pulmonary hypertension...

are constricted and blood cannot flow to the tissues. Iloprost is a prostacyclin mimetic. For pulmonary arterial hypertension, iloprost is given via inhalation...

ACT-333679 (or MRE-269, the free carboxylic acid), are agonists of the prostacyclin receptor, which leads to vasodilation in the pulmonary circulation. It...

formation on damaged sites of small blood vessels and decrease of PgI2 (Prostacyclin) synthesis; it also facilitates platelet aggregation and adhesion, that...

degradation products that inhibit excessive fibrin formation.[citation needed] Prostacyclin (PGI2) is released by endothelium and activates platelet Gs protein-linked...

whose selective inhibition results in levels of prostaglandin I2 (PGI2, prostacyclin) down-regulated relative to thromboxane (since COX-1 in platelets is...

deterioration is nuanced and uncertain. Normally endothelial cells release prostacyclin and nitric oxide (NO) which induce relaxation of the smooth muscle cells...

involving cyclooxygenase-2 and prostacyclin and increases nitric oxide bioavailability in the endothelium. Endogenous prostacyclin (PGI2) plays a critical role...

thrombomodulin, and prevent platelet aggregation with nitric oxide and prostacyclin. When endothelium of a blood vessel is damaged, the endothelial cells...

effect. There is moderate certainty evidence that intravenous iloprost (prostacyclin analogue) is more effective than aspirin for relieving rest pain and...

injection (IP injection), the injection of a substance into the peritoneum Prostacyclin receptor (symbol PTGIR, older synonym IP) IP address, a numerical label...

(dinoprost) Sulotroban Tafluprost Travoprost Unoprostone IP (I2)Tooltip Prostacyclin receptor Agonists: ACT-333679 AFP-07 Beraprost BMY-45778 Carbacyclin...

inhibited platelet aggregation. PG-X, which later would become known as prostacyclin, was 30 times more potent than any other known anti-aggregatory agent...

catalyzed cyclooxygenase and lipoxygenase, increases the correlation prostacyclin/ thromboxane A2 and blocks the leukotriene formation. Increases the content...

blood vessels, which leads to a decrease in the production of prostacyclin in them. Prostacyclin usually prevents platelet aggregation and vasoconstriction...

regulating oxidative stress by releasing mediators, such as nitric oxide, prostacyclin and endothelin, and by controlling local angiotensin-II activity. Dysfunctional...

management company PGI, IATA code for Chitato Airport in Angola PGI2 (Prostacyclin), a chemical which regulates blood clotting Phosphoglucose isomerase...

(dinoprost) Sulotroban Tafluprost Travoprost Unoprostone IP (I2)Tooltip Prostacyclin receptor Agonists: ACT-333679 AFP-07 Beraprost BMY-45778 Carbacyclin...

(dinoprost) Sulotroban Tafluprost Travoprost Unoprostone IP (I2)Tooltip Prostacyclin receptor Agonists: ACT-333679 AFP-07 Beraprost BMY-45778 Carbacyclin...

Specialized pro-resolving mediators § Prostaglandins and isoprostanes). Prostacyclins include: PGI2. Thromboxanes (TX) include the following metabolites of...

aggregation. It is in homeostatic balance in the circulatory system with prostacyclin, a related compound. The mechanism of secretion of thromboxanes from...