• Thumbnail for RAD51
    DNA repair protein RAD51 homolog 1 is a protein encoded by the gene RAD51. The enzyme encoded by this gene is a member of the RAD51 protein family which...
    48 KB (5,526 words) - 18:39, 27 October 2024
  • Thumbnail for RI-1 (chemical)
    of RAD51, which is a central gene molecule of homologous recombination, with IC50 ranging from 5 to 30 μM. RAD51 is a eukaryote gene, encoding RAD51 protein...
    3 KB (280 words) - 13:20, 10 July 2023
  • Thumbnail for Fanconi anemia
    "S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51". Blood. 100 (7): 2414–20. doi:10.1182/blood-2002-01-0278. PMID 12239151...
    37 KB (4,138 words) - 03:05, 19 October 2024
  • Thumbnail for BRCA2
    the recombinase RAD51 to stimulate and maintain strand invasion, a vital step of homologous recombination. The localization of RAD51 to the DNA double-strand...
    72 KB (7,870 words) - 01:08, 25 September 2024
  • Thumbnail for DMC1 (gene)
    DMC1 (gene) (section Rad51)
    eukaryotic cells, the other being Rad51. DMC1 and RAD51 share over 50% amino acid similarity. In budding yeast, Rad51 serves as a strand exchange protein...
    20 KB (2,578 words) - 09:01, 18 January 2024
  • recombinational repair. The RadA recombinase has greater similarity to the eukaryotic Rad51 recombinase than to the bacterial RecA recombinase. RecA recombinase appears...
    7 KB (757 words) - 08:07, 5 October 2024
  • Thumbnail for Synthesis-dependent strand annealing
    dismantles Rad51 filaments during meiosis. By directly interacting with Rad51, Srs2 dislodges Rad51 from nucleoprotein filaments thereby inhibiting Rad51-dependent...
    15 KB (1,827 words) - 17:31, 13 November 2024
  • Thumbnail for PALB2
    binds the single strand DNA and directly interacts with the recombinase RAD51 to stimulate strand invasion, a vital step of homologous recombination,...
    18 KB (1,567 words) - 01:04, 10 March 2024
  • Thumbnail for RAD52
    DNA recombination protein RAD51, which suggested its role in RAD51-related DNA recombination and repair. RAD52 mediates RAD51 function in homologous recombinational...
    23 KB (3,013 words) - 01:47, 11 April 2024
  • Thumbnail for Double-strand break repair model
    ends of the DSB are processed into ssDNA with 3’ extensions, which allows RAD51 recombinase (eukaryotic homologue of prokaryotic RecA) to bind to it to...
    36 KB (4,324 words) - 17:45, 17 October 2024
  • Thumbnail for Fungus
    called DMC1, which is a conserved homologue of genes recA in bacteria and RAD51 in eukaryotes, that mediates homologous chromosome pairing during meiosis...
    200 KB (19,205 words) - 21:46, 10 November 2024
  • Thumbnail for RAD51L3
    protein RAD51 homolog 4 is a protein that in humans is encoded by the RAD51L3 gene. The protein encoded by this gene is a member of the RAD51 protein...
    11 KB (1,334 words) - 11:51, 30 July 2024
  • Thumbnail for RAD51C
    RAD51 homolog C (S. cerevisiae), also known as RAD51C, is a protein which in humans is encoded by the RAD51C gene. The RAD51C protein is one of five paralogs...
    24 KB (2,984 words) - 02:05, 21 October 2024
  • Thumbnail for RecA
    class of homologous DNA repair proteins. The homologous protein is called RAD51 in eukaryotes and RadA in archaea. RecA has multiple activities, all related...
    13 KB (1,428 words) - 12:25, 29 October 2024
  • Thumbnail for Chromosomal crossover
    such particular protein complex that is conserved between processes is RAD51, a well conserved recombinase protein that has been shown to be crucial...
    32 KB (3,709 words) - 22:10, 25 July 2024
  • Thumbnail for Menopause
    necessary for homologous recombinational repair during meiosis (BRCA1, MRE11, Rad51, and ATM) decline with age in oocytes. This age-related decline in ability...
    89 KB (10,178 words) - 04:01, 9 November 2024
  • Thumbnail for Amoeba
    identified in the Acanthamoeba genome. These genes included Spo11, Mre11, Rad50, Rad51, Rad52, Mnd1, Dmc1, Msh and Mlh. This finding suggests that the ‘'Acanthamoeba'’...
    51 KB (4,923 words) - 23:25, 12 November 2024
  • Thumbnail for Monoecy
    meiosis to produce pollen grains. Meiosis in maize requires gene product RAD51, a protein employed in recombinational repair of DNA double-strand breaks...
    12 KB (1,126 words) - 21:41, 29 October 2024
  • Thumbnail for Tetrahymena thermophila
    ciliates such as T. thermophila utilize a Rad51-dependent recombinational pathway to repair damaged DNA. The Rad51 recombinase of T. thermophila is a homolog...
    16 KB (1,723 words) - 07:50, 28 September 2024
  • Thumbnail for DNA
    recombination reaction is catalyzed by enzymes known as recombinases, such as RAD51. The first step in recombination is a double-stranded break caused by either...
    166 KB (17,843 words) - 13:16, 19 September 2024
  • Thumbnail for Entamoeba histolytica
    the recombinational DNA repair pathway. In particular, expression of the Rad51 protein (a recombinase) is increased about 15-fold by UV treatment. List...
    31 KB (3,041 words) - 16:22, 25 September 2024
  • Thumbnail for FANCD2
    "S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51". Blood. 100 (7): 2414–20. doi:10.1182/blood-2002-01-0278. PMID 12239151...
    24 KB (2,547 words) - 15:10, 19 September 2024
  • break (DSB) repair. Polyamines enhance the DNA strand exchange activity of RAD51 recombinase. Depletion of polyamines sensitizes cells to genotoxic substances...
    15 KB (1,645 words) - 14:28, 22 June 2024
  • Thumbnail for XRCC2
    humans is encoded by the XRCC2 gene. This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to...
    15 KB (1,849 words) - 15:34, 5 January 2024
  • Thumbnail for Mitosis
    PMID 1427035. Botthof JG, Bielczyk-Maczyńska E, Ferreira L, Cvejic A (May 2017). "rad51 leads to Fanconi anemia-like symptoms in zebrafish". Proceedings of the...
    71 KB (7,317 words) - 22:13, 2 November 2024
  • Thumbnail for SOS response
    repair and mutagenesis are induced. The system involves the RecA protein (Rad51 in eukaryotes). The RecA protein, stimulated by single-stranded DNA, is...
    13 KB (1,498 words) - 05:34, 29 September 2024
  • Thumbnail for DNA repair
    damages. The over-expression of RAD51 and BRCA2 seen in these cancers may reflect selective pressures for compensatory RAD51 or BRCA2 over-expression and...
    129 KB (15,900 words) - 22:25, 12 October 2024
  • Thumbnail for Homology directed repair
    polymerase. After this, Rad51 replaces RPA and forms filaments on the DNA strand. Working together with BRCA2 (Breast Cancer Associated), Rad51 couples a complementary...
    9 KB (1,265 words) - 11:50, 29 October 2024
  • Thumbnail for Cryptococcus neoformans
    conserved homologue of genes recA in bacteria, and rad51 in eukaryotes (see articles recA and rad51). Dmc1 mediates homologous chromosome pairing during...
    27 KB (3,101 words) - 23:53, 17 August 2024
  • Thumbnail for Homologous recombination
    Rad51, Dmc1 and RadA proteins indicate that they are monophyletic, or that they share a common molecular ancestor. Within this protein family, Rad51 and...
    106 KB (12,117 words) - 07:58, 5 October 2024