The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing...

JAKs contains a FERM domain (approximately 400 residues), an SH2-related domain (approximately 100 residues), a kinase domain (approximately 250 residues)...

contain six conserved domains: a N-terminal myristoylated segment, a SH2 domain, a SH3 domain, a linker region, a tyrosine kinase domain, and C-terminal tail...

one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds...

SH2 may stand for: SH2 (classification), a Paralympic shooting classification SH2 domain (Src Homology 2), a protein domain within the Src oncoprotein...

Src) gene of Rous sarcoma virus. It includes an SH2 domain, an SH3 domain and a tyrosine kinase domain. Two transcript variants encoding the same protein...

via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains". The Journal of Biological...

(SH2) domain containing inositol polyphosphate 5-phosphatase 1 (SHIP1) is an enzyme with phosphatase activity. SHIP1 is structured by multiple domain and...

domains SH2 and SH3, as well as a protein kinase domain with tyrosine phosphorylation activity. Part of the TH domain is folded against the PH domain while...

memory T cells. These differences are due to differential regulation by SH2 domain–containing phosphatase-1 (Shp-1) and C-terminal Src kinase. Lck is responsible...

PLCγ by its SH2 domains. Figure 1 on the extreme right shows the PLCγ-FGFR1 kinase complex with the c-SH2 domain colored in red, n-SH2 domain colored in...

possesses a domain structure that consists of two tandem SH2 domains in its N-terminus followed by a protein tyrosine phosphatase (PTP) domain. In the inactive...

the protein-protein interaction domains in nRTKs are the Src homology 2 (SH2) and 3 (SH3) domains. The longer SH2 domain (~100 residues) binds phosphotyrosine...

C-terminal GAP domain Mitogenic signal transmission towards downstream interacting partners through its N-terminal SH2-SH3-SH2 domains The protein encoded...

TRIP10 (cip4) Src homology 2 domain-containing Structural domain Pawson T, Schlessingert J (July 1993). "SH2 and SH3 domains". Current Biology. 3 (7): 434–42...

term "SH2" domain stands for src-homology 2 domain, which is a three-dimensional domain structure of about 100 amino acid residues. These domains are present...

Adaptor proteins usually contain several domains within their structure (e.g., Src homology 2 (SH2) and SH3 domains) that allow specific interactions with...

Hematopoietic SH2 Domain Containing (HSH2D) protein is a protein encoded by the hematopoietic SH2 domain containing (HSH2D) gene. HSH2D is located on chromosome...

has actin-binding sites, an SH2 (Pfam PF00017) domain and a region similar to the tumour suppressor PTEN. The PTB domain interacts with the cytoplasmic...

RTKs are recognized by a phosphodependent-binding domain, the SH2 domain. The recruitment of SH2 domain proteins to autophosphorylated RTKs at the plasma...

membrane trafficking. Src homology 2 domain (SH2): SH2 domains are often found in signal transduction proteins. SH2 domains confer binding to phosphorylated...

non-receptor tyrosine kinases share a characteristic dual SH2 domain separated by a linker domain. However, activation of SYK relies less on phosphorylation...

most widely reported as interacting with the PECAM-1 cytoplasmic domain is SH2 domain–containing protein-tyrosine phosphatase SHP-2. Signaling through...

essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner". Cell. 66 (1): 161–71...

homology binding domains (SH2/SH3) and the presence of up to seven JAK homology domains (JH1-JH7). Nonetheless the terminal JH domains retain a high level...

C-terminal C2 domain. Specific to the PLCG isozymes is a large separation between the X and Y domains consisting of a split PH domain, tandem SH2 domains, and...

docking site to which a number of signaling proteins bind, including the SH2-domain-containing leukocyte protein of 76 kDa (SLP-76). SLP-76 is also phosphorylated...

this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP...

cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem...

SH2 domain-containing protein 2A is a protein that in humans is encoded by the SH2D2A gene. SH2D2A has been shown to interact with MAP3K2. GRCh38: Ensembl...