sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene. SOS1 is a guanine nucleotide exchange factor (GEF) which interacts with...

each ommatidium fails to form. Similarly, the mammalian orthologues of Sos, SOS1 and SOS2, function downstream of many growth factor and adhesion receptors...

key ones being PTPN11 accounting for 50% of genetically diagnosed cases, SOS1 responsible for 10-13% of cases, and RAF1 or RIT1 - each contributing to...

pathway at or above the level of SOS1. SOS1 in turn regulates the activities of RAS, RAF, MEK, ERK, and p90RSK. SOS1 has been demonstrated to be a target...

(SOS1) is an important GEF in the cell growth-regulatory MAPK/ERK pathway. SOS1 binds GRB2 at the plasma membrane after EGF receptor activation. SOS1 activates...

mutation in the SOS1 gene localized on chromosome 2p21-p22 HGF2 - Caused by a mutation in the SOS1 gene localized on chromosome 5q13-q22[[[SOS1...

then activates SOS1. Finally, this causes the extrusion of any extra Sodium to the outside through Na+/H+ antiporter which is near SOS1. The SOS2-SOS3...

more types of RASopathy: HRAS KRAS NRAS RRAS RIT1 NF1 RASA1 RASA2 SYNGAP1 SOS1 SOS2 CBL PTPN11 BRAF RAF1 MAP2K1 MAP2K2 MAP3K8 SPRED1 SPRY1 MYST4 LZTR1 A2ML1...

phosphorylation of SOS1 (Son of Sevenless) at Serines 1134 and 1161 creates 14-3-3 docking site. This interaction of phospho SOS1 and 14-3-3 negatively...

cytoplasm, inhibiting their function. Raf-1 Bad – see Bcl-2 Bax Cdc25 Akt SOS1 – see RSK YWHAB – "14-3-3 beta" YWHAE – "14-3-3 epsilon" YWHAG – "14-3-3...

small G proteins that activate guanine nucleotide exchange factors such as SOS1. Once activated, these exchange factors can activate more small G proteins...

GCSH recessive 1:60,000 Nonsyndromic deafness Noonan syndrome PTPN11, KRAS, SOS1, RAF1, NRAS, HRAS, BRAF, SHOC2, MAP2K1, MAP2K2, CBL dominant 1:1,000 Norman–Roberts...

alpha, PLCG1, PLSCR1, PTPN1, PTPN11, PTPN6, PTPRK, SH2D3A, SH3KBP1, SHC1, SOS1, Src, STAT1, STAT3, STAT5A, UBC, and WAS, PAR2. In fruitflies, the epidermal...

1701963 is an investigational drug that blocks KRAS activation by binding to SOS1 proteins. The drug is thought to be effective in cancers with a KRAS mutation...

proteins of the Guanine Nucleotide Exchange Factor (GEF) class (such as SOS1), which forces the release of bound nucleotide (GDP). Subsequently, KRAS...

衛星ヌーンの決戦 Masahiro Sasaki Masaki Tsuji 5 時のロスト‧ワールド (The Lost World of Time) SOS1億年前 Kozo Morishita Masaki Tsuji 6 聖なる星クウムの謎 Tomoharu Katsumata Masaki Tsuji...

of conformations when binding GTP or GDP or no nucleotide (when bound to SOS1, which releases the nucleotide). Ras also binds a magnesium ion which helps...

ABI1 gene. Abl interactor 1 has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to...

SGEF, SH2B, SH2B1, SH2B2, SH2B3, SH3BP2, SKAP1, SKAP2, SNTA1, SNTB1, SNTB2, SOS1, SOS2, SPATA13, SPNB4, SPTBN1, SPTBN2, SPTBN4, SPTBN5, STAP1, SWAP70, SYNGAP1...

2006). "Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1". Molecular Biology of the Cell. 17 (8): 3591–7. doi:10.1091/mbc.E05-12-1104...

proteins SPRY1, SPRY2, SPRY3, and/or SPRY4 which in turn interact with GRB2, SOS1, and/or c-Raf to reduce or inhibit further cell stimulation by activated...

proteins of the Guanine Nucleotide Exchange Factor (GEF) class, for example SOS1, which forces the release of bound nucleotide. Subsequently, GTP present...

to Sos1 during cell cycling. Sos1 and SHIP both bind to Shc competitively and by having an increased affinity for Shc during phosphorylation, Sos1 binding...

recruited independently of p85. For example, Grb2 can also bind the Ras-GEF Sos1, leading to activation of Ras. Ras-GTP then activates the p110 subunit of...

"Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and...

CD117, CRKL FES, Grb2, GRB10, HCK, MLLT4, PXN, PIK3CG, PTPN6, PTPRT(PTPrho) SOS1, and XPB. Abl gene GRCh38: Ensembl release 89: ENSG00000186716 – Ensembl...

There are two sorts of Special Ordered Sets: Special Ordered Sets of type 1 (SOS1 or S1): are a set of variables, at most one of which can take a non-zero...

RASGRF2; RASGRP1; RASGRP2; RASGRP3; RASGRP4; RGL1; RGL2; RGL3; RGL4/RGR; SOS1; SOS2; Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J (July 1998)...

kinase 2, LAIR1, LRP1, PDGFRB, PI3K → Akt PLCG2, PTK2B, Ras SLAMF1, SOCS3, SOS1, STAT3, STAT5A, and STAT5B. CagA is a protein and virulence factor inserted...

protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. GRAP has...