TBK1 (TANK-binding kinase 1) is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. It is encoded by the TBK1 gene...

to: The Black Keys "The" Brian Kendrick The Brothers Karamazov TANK-binding kinase 1 Teargarden by Kaleidyscope The Big Kahuna (film) Funnelbeaker culture...

TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1". J Immunol. 186 (1): 499–507. doi:10.4049/jimmunol.0903534. PMID 21106850...

scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD (TANK-binding kinase 1-binding protein 1) can be recruited to the IKBKE-containing-complexes...

cell lung cancer. Inhibition of IκB kinase (IKK) and IKK-related kinases, IKBKE (IKKε) and TANK-binding kinase 1 (TBK1), has been investigated as a therapeutic...

different isoforms have been found for this gene. TANK (gene) has been shown to interact with TANK-binding kinase 1, IKBKE, TRAF2, IKBKG and TRAF3. GRCh38: Ensembl...

RNA sensing. The MAVS signaling complex interacts with TANK binding kinase 1 and/or protein kinases IKKA (CHUK) and IKKB (IKBKB), which leads to the phosphorylation...

receptor-associated factor 3) and subsequently the IKKε/TBK1 (I-kappa-B kinase-epsilon/TANK-binding kinase 1) complex are recruited. The IKKε/TBK1 complex leads to the...

Koyama S, Matsui K, Kumar H, Kawai T, et al. (February 2008). "TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines"...

NF-κB-independent manner. Inhibition of IκB kinase (IKK) and IKK-related kinases, IKBKE (IKKε) and TANK-binding kinase 1 (TBK1), has been investigated as a therapeutic...

TBK1 may refer to: TANK-binding kinase 1, an enzyme IkappaB kinase, an enzyme This disambiguation page lists articles associated with the same title formed...

ligase TRAF3 followed by the activation of non-canonical IKK kinases: TANK binding kinase 1 (TBK1) and IKKε. TBK1 phosphorylates the pLxIS consensus motif...

MAP3K1, MAP3K7IP2, MAP4K2, MAP4K5, RANK, RIPK1, SPHK1, TANK, TANK-binding kinase 1, TNFAIP3, TNFRSF13B, TNFRSF14, TNFRSF1A, TNFRSF1B, TNFSF14, TRADD,...

activating kinase (NAK, i.e. TANK-binding kinase-1 (TBK1) and TRAF2-associated kinase (T2K)). The fact that RELA can be modified by a collection of kinases via...

assemble the beclin-1–VPS34 autophagy initiation complex, and with Sec5 to activate the innate immune response via the Tank-binding kinase 1 (TBK1). Ral proteins...

ubiquitously expressed IRFs (IRF1, IRF3, and IRF7) through IRF kinases, such as TANK-binding kinase 1 (TBK1). Phosphorylated IRFs are translocated to the nucleus...

NF-κB activation. Binding of IKK-γ to IKK-α and IKK-β subunits activates the IKK complex leading to phosphorylation of IκB kinase, IκBα, and release...

are found on a strikingly wide range of proteins, including helicases, kinases, mitochondrial proteins, caspases, and other cytoplasmic factors. CARDs...

"Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases". The Journal of Biological...

in-house computer-generated models of drugs binding to their targets. The Institute functions as a scientific think tank and performs no actual laboratory work...

activation of second messenger-dependent protein kinases. PKA and PKC, as well as tyrosine kinases, have been shown to phosphorylate the nAChR resulting...

binding to the B-cell lymphoma 10 (Bcl10) protein and a caspase-like domain. The death domain and immunoglobulin-like domains participate in binding to...

It may also cause mild side effects such as headache and nausea. Janus kinase (JAK) inhibitors are used to treat RA. Similar to biologic response modifiers...

after mutations occur within intermediates of the pathway. Three TRAF-binding motifs present in the amino terminal region of TICAM1 are necessary for...

Mitogen-activated protein kinase kinase kinase kinase 5 is an enzyme that in humans is encoded by the MAP4K5 gene. This gene encodes a member of the serine/threonine...

NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". The Journal of Biological Chemistry...

cells using cell-specific promoters like Ca2+/calmodulin-dependent protein kinase II (CaMKII) and human synapsin (hSyn) that confer excitatory neuronal and...

understood mechanisms include phosphorylation by the second messenger protein kinase C (PKC). PKC has been shown to inhibit NET function by sequestration of...

bovis lacks pyruvate kinase activity, due to pykA containing a point mutation that affects binding of Mg2+ cofactor. Pyruvate kinase catalyses the final...

KA, Brill A, Lymperopoulos A (2015). "Adrenal G protein-coupled receptor kinase-2 in regulation of sympathetic nervous system activity in heart failure"...