member 5 (TRPM5), also known as long transient receptor potential channel 5 is a protein that in humans is encoded by the TRPM5 gene. TRPM5 is a calcium-activated...

steviol glycosides and steviol interact with a protein channel called TRPM5, potentiating the signal from the sweet or bitter receptors, amplifying...

permeability of calcium and magnesium varies widely among TRPM channels. TRPM4 and TRPM5 are impermeable to calcium. TRPM3, TRPM6 and TRPM7 are highly permeable...

endoplasmic reticulum. This increase in intracellular calcium activates the TRPM5 channel and induces cellular depolarization. The ATP release channel CALHM1...

others. βTRPMs include, but are not limited to, vertebrate TRPM2, TRPM4, TRPM5, and TRPM8 (the cold and menthol sensor). Two additional major clades have...

Calcium activates a so-called transient-receptor-potential cation channel TRPM5 that leads to membrane depolarization and the consequent release of ATP...

Ketoconazole has been found to inhibit the activity of the cation channel TRPM5. When administered orally, ketoconazole is best absorbed at highly acidic...

decreased neuronal response to oral fatty acids. Monovalent cation channel TRPM5 has been implicated in fat taste as well, but it is thought to be involved...

vision transduction. Additionally, taste receptors share the use of the TRPM5 ion channel, as well as a phospholipase PLCβ2. The TAS1R1+TAS1R3 heterodimer...

organ's specific functions. Tuft cells express chemosensory proteins, like TRPM5 and α-gustducin. These proteins indicate that neighbouring neurons can innervate...

channels. TRPC1; TRPC3; TRPC4; TRPC5; TRPC6; TRPC7 TRPM1; TRPM2; TRPM3; TRPM4; TRPM5; TRPM6; TRPM7; TRPM8 TRPV1; TRPV2; TRPV3; TRPV4; TRPV5; TRPV6 MCOLN1; MCOLN2;...

(PIP2) pathway. The nonselective cation Transient Receptor Potential channel TRPM5 has been shown to correlate with both umami and sweet taste. Also, the phospholipase...

trans-membrane taste receptors, the G-protein gustducin, PLCbeta2, IP3R3, TRPM5). Usually, in chemosensory cluster a true "taste pore" is lacking. To date...

O94759 17471 TRPM3 HGNC:17992 Q9HCF6 17472 TRPM4 HGNC:17993 Q8TD43 17473 TRPM5 HGNC:14323 Q9NZQ8 17474 TRPM6 HGNC:17995 Q9BX84 17475 TRPM7 HGNC:17994 Q96QT4...

trans-membrane taste receptors, the G-protein gustducin, PLCbeta2, IP3R3, TRPM5). Morphologically, the elements of the DCS are polymorphic. Some of them...

transducing 3 Localization of G14 and G-gustducin in type II taste cells. TrpM5 is a cation channel of the TRP superfamily that is highly expressed in taste...

trans-membrane taste receptors, the G-protein gustducin, PLCbeta2, IP3R3, TRPM5). Morphologically, the elements of SCCs are polymorphic. Some of them have...

(PIP2) pathway. The nonselective cation Transient Receptor Potential channel TRPM5 has been shown to correlate with both umami and sweet taste. Also, the phospholipase...

TRPC1 TRPC2 TRPC3 TRPC4AP TRPC5 TRPC6 TRPC7 TRPM TRPM1 TRPM2 TRPM3 TRPM4 TRPM5 TRPM6 TRPM7 TRPM8 TRPML TRPN TRPP TRPP3 TRPV TRPV1 TRPV2 TRPV3 TRPV4 TRPV5...

Margolskee’s laboratory discovered the T1r3 sweet taste receptor in 2001 and the Trpm5 cation channel in 2002. Much of his current work is focused on 'taste cells...

for type I cells, α-gustducin, transient receptor potential melastatin 5 (TRPM5), and phospholipase C β2 (PLCβ2) for type II cells, and synaptosomal-associated...

known as transient receptor potential cation channel subfamily M member 5 (TRPM5). Ca2+-flux signaling assays are commonly used to measure the function of...

reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential...

Voets T, Ninomiya Y & Nilius B. (2008). The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions. FASEB J 22, 1343-1355 "Article"...