A telomere (/ˈtɛləmɪər, ˈtiːlə-/; from Ancient Greek τέλος (télos) 'end' and μέρος (méros) 'part') is a region of repetitive nucleotide sequences associated...

A telomere is a region of repetitive nucleotide sequences at each end of a chromosome. Telomere may also refer to: Telomere (insect morphology), a type...

The relationship between telomeres and longevity and changing the length of telomeres is one of the new fields of research on increasing human lifespan...

Telomeres, the caps on the ends of eukaryotic chromosomes, play critical roles in cellular aging and cancer. An important facet to how telomeres function...

ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. A telomere is a region of repetitive sequences at each...

expression of an enzyme called telomerase. This enzyme extends telomeres, preventing the telomeres of cancer cells from shortening and giving them infinite...

of telomeres is now clearly evident: lengthen the telomeres, lengthen the life. However, a study of the comparative biology of mammalian telomeres indicated...

1984, Blackburn co-discovered telomerase, the enzyme that replenishes the telomere, with Carol W. Greider. For this work, she was awarded the 2009 Nobel Prize...

Lengthening of Telomeres (also known as "ALT") is a telomerase-independent mechanism by which cancer cells avoid the degradation of telomeres. At each end...

A mega-telomere (also known as an ultra-long telomere or a class III telomere), is an extremely long telomere sequence that sits on the end of chromosomes...

Telomere-binding proteins (also known as TERF, TRBF, TRF) function to bind telomeric DNA in various species. In particular, telomere-binding protein refers...

A telomere (pl.; telomeres or telomeron), literally "end piece", is a term in insect morphology, and refers to a type of "genital clasper"; i.e.: in Mallophaga...

California, Berkeley. Greider pioneered research on the structure of telomeres, the ends of the chromosomes. She was awarded the 2009 Nobel Prize for...

complex specialized DNA protective packages called telomeres that prevent DNA repair activities. Telomeres and mitotic DSBs have different functionality,...

Telomere resolvase, also known as protelomerase, is an enzyme found in bacteria which contain linear plasmids. In order to prevent exonuclease degradation...

structure. In addition to these stacked structures, telomeres also form large loop structures called telomere loops, or T-loops. Here, the single-stranded DNA...

repeat–containing RNA (TERRA) is a long non-coding RNA transcribed from telomeres - repetitive nucleotide regions found on the ends of chromosomes that...

below: Primary hallmarks (causes of damage) Genome instability Telomere shortening (or telomere attrition) Epigenetic alterations Loss of proteostasis Antagonistic...

Ala-Glu-Asp-Gly and the molecular formula C14H22N4O9. Epitalon appears to induce telomere elongation via increased telomerase activity in human somatic cells in...

to study telomere length, which in vertebrates are repetitive hexameric sequences (TTAGGG) located at the distal end of chromosomes. Telomeres are necessary...

senescence can be triggered by a DNA damage response due to the shortening of telomeres. Cells can also be induced to senesce by DNA damage in response to elevated...

point at which cells can no longer divide due to DNA damage or shortened telomeres. Prior to Leonard Hayflick's theory, Alexis Carrel hypothesized that all...

Shelterin (also called telosome) is a protein complex known to protect telomeres in many eukaryotes from DNA repair mechanisms, as well as to regulate...

chromosomes. Named regions include: Arms (p and q) Centromere Kinetochore Telomere Sub telomere satellite chromosome or trabant. NOR region During cell division...

into a large chromosome (which contains remnants of the centromere and telomeres of the ancestral 12 and 13). Chromosomes 6, 13, 19, 21, 22, and X are...

validated to be CTCGGTTATGGG A bioinformatics method for detecting this unique telomere sequence was demonstrated using SERF de novo Genome Analysis Many Allium...

Medicine and the Director of the Telomere Center at Johns Hopkins University. Her research focuses on the role of telomeres in disease. Armanios graduated...

G-overhang at human telomere ends, which could inhibit the proper formation of the so-called T-loop, destabilizing the telomere as a whole. Telomere lengthening...

multisystem X-linked recessive disorder characterized by excessively short telomeres and is considered a severe form of dyskeratosis congenita. Being an X-linked...

involves telomeres. It is thought that the WRN helicase activity is important not only for DNA repair and recombination, but also for maintaining telomere length...