• Thumbnail for Telomeric repeat-binding factor 2
    Telomeric repeat-binding factor 2 is a protein that is present at telomeres throughout the cell cycle. It is also known as TERF2, TRF2, and TRBF2, and...
    27 KB (3,340 words) - 22:06, 22 December 2023
  • Thumbnail for Telomeric repeat-binding factor 1
    Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the TERF1 gene. The human TERF1 gene is located in the chromosome 8 at 73...
    20 KB (2,474 words) - 11:36, 23 December 2023
  • Thumbnail for Telomeric repeat–containing RNA
    Telomeric repeat–containing RNA (TERRA) is a long non-coding RNA transcribed from telomeres - repetitive nucleotide regions found on the ends of chromosomes...
    35 KB (4,668 words) - 11:25, 11 February 2024
  • Thumbnail for TERF2IP
    Telomeric repeat-binding factor 2-interacting protein 1 also known as repressor activator protein 1 (Rap1) is a protein that in humans is encoded by the...
    9 KB (1,161 words) - 18:14, 7 August 2022
  • telomere-binding protein refers to TTAGGG repeat binding factor-1 (TERF1) and TTAGGG repeat binding factor-2 (TERF2). Telomere sequences in humans are...
    13 KB (1,658 words) - 08:34, 4 December 2022
  • replication problem". In white blood cells, the gradual shortening of telomeric DNA has been shown to inversely correlate with ageing in several sample...
    67 KB (7,394 words) - 16:46, 2 September 2024
  • Thumbnail for Telomere
    Telomere (redirect from Telomeric)
    DNA repair machinery. Should non-homologous end joining occur at the telomeric ends, chromosomal fusion would result. The T-loop is maintained by several...
    44 KB (4,924 words) - 18:51, 31 October 2024
  • Thumbnail for Long non-coding RNA
    Khoriauli L, Giulotto E, Lingner J (November 2007). "Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends". Science. 318 (5851):...
    121 KB (13,137 words) - 03:37, 18 November 2024
  • Thumbnail for G-quadruplex
    Dash D, Chowdhury S (November 2019). "Telomere Repeat-Binding Factor 2 Binds Extensively to Extra-Telomeric G-quadruplexes and Regulates the Epigenetic Status...
    94 KB (11,911 words) - 03:22, 31 October 2024
  • Thumbnail for RNA-binding protein FUS
    human telomeric DNA in vitro. Beyond nucleic acid binding, FUS/TLS was also found to associate with both general and more specialized protein factors to...
    32 KB (3,968 words) - 22:39, 23 September 2024
  • PMID 31072070. Cusanelli E, Chartrand P (May 2014). "Telomeric noncoding RNA: telomeric repeat-containing RNA in telomere biology". Wiley Interdisciplinary...
    42 KB (4,774 words) - 17:56, 3 November 2024
  • Shelterin (category Telomere-binding proteins)
    about ten times more abundant than TPP1 and POT1. TRF1 (Telomere Repeat binding Factor 1): TRF1 is a homodimeric protein that binds to the double-stranded...
    21 KB (2,334 words) - 22:04, 20 September 2024
  • Thumbnail for RTL6
    (August 2010). "The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1". PLOS ONE. 5 (8): e12407. Bibcode:2010PLoSO...
    20 KB (1,947 words) - 11:18, 21 May 2024
  • Thumbnail for DUX4
    present, telomeric to the D4Z4 repeat array. The open reading frame (ORF) is entirely contained within exon 1 and contains two homeoboxes. Exons 2 and 3...
    7 KB (706 words) - 19:30, 22 July 2024
  • Thumbnail for Tankyrase 2
    S (2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a...
    7 KB (822 words) - 06:18, 5 January 2024
  • Thumbnail for Eukaryotic DNA replication
    single stranded 3' end of the template DNA and contains 1.5 copies of the telomeric sequence. Telomerase contains a protein subunit that is a reverse transcriptase...
    119 KB (14,646 words) - 22:02, 3 July 2024
  • Thumbnail for Human herpesvirus 6
    possible as a result of the telomeric repeats found within the direct repeat termini of HHV-6's genome. The right direct repeat terminus integrates within...
    78 KB (8,112 words) - 16:36, 5 July 2024
  • Thumbnail for HMBOX1
    Subsequently, direct binding to telomeric DNA was demonstrated through a co-crystal structure of the DNA-binding domain of HMBOX1 with telomeric DNA. Loss-of-function...
    4 KB (452 words) - 01:09, 9 April 2022
  • Thumbnail for Facioscapulohumeral muscular dystrophy
    1 encodes for DUX4 protein. Exon 3 is in the pLAM region telomeric to the last partial repeat, and it can vary in length depending on the type of 4qA allele...
    176 KB (16,456 words) - 00:30, 6 November 2024
  • Thumbnail for Tankyrase
    (Apr 2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a...
    12 KB (1,493 words) - 17:10, 2 December 2023
  • Thumbnail for Stress granule
    associated with 40S ribosomal subunits, translation initiation factors, poly(A)+ mRNA and RNA-binding proteins (RBPs). While they are membraneless organelles...
    183 KB (12,460 words) - 13:46, 23 September 2024
  • Thumbnail for TNKS1BP1
    (Apr 2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a...
    6 KB (663 words) - 00:53, 4 March 2023
  • Thumbnail for DNA end resection
    inhibitory effect by binding to telomeric DNA. In the Late S/G2 phase, the protein kinase CDK1 (cyclin-dependent) promotes telomeric resection. This control...
    18 KB (2,277 words) - 13:23, 26 November 2023
  • Thumbnail for Chromosome 5
    1, telomeric SMN2: survival motor neuron 2, centromeric SNCAIP: synuclein, alpha interacting protein (synphilin) SPEF2: Sperm flagellar protein 2 SPINK5:...
    32 KB (2,298 words) - 22:55, 28 March 2024
  • MeSH D12.776.660.235.700.750 – telomeric repeat binding protein 1 MeSH D12.776.660.235.700.875 – telomeric repeat binding protein 2 MeSH D12.776.660.352.500...
    9 KB (356 words) - 16:49, 9 February 2024
  • ISBN 978-3-319-21755-0. PMID 26860303. Sundquist WI, Klug A (December 1989). "Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops"....
    11 KB (1,202 words) - 06:34, 26 April 2024
  • mating type loci and at yeast telomeres, the transcription factors Abf1 (ARS binding factor) and Rap1 (repressor-activator protein) associate with specific...
    19 KB (2,343 words) - 01:04, 3 December 2023
  • Thumbnail for DNA replication
    single-stranded DNA binding proteins (SSB). In the replication machineries these components coordinate. In most of the bacteria, all of the factors involved in...
    60 KB (7,286 words) - 00:09, 20 November 2024
  • Thumbnail for Telomerase
    Telomerase (category EC 2.7.7)
    Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA. Nat Struct Mol Biol. 2010 Apr;17(4):513-8 NCBI - telomerase...
    49 KB (5,697 words) - 14:29, 22 November 2024
  • Thumbnail for Cortactin
    in breast and squamous cell carcinomas encompasses three CpG islands telomeric of FGF3, including the expressed gene EMS1". Genes Chromosomes Cancer...
    21 KB (2,576 words) - 11:30, 27 March 2024