Thymidylate synthase (TS) (EC 2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate...
16 KB (1,902 words) - 00:29, 10 March 2024
Thymidylate synthase inhibitors are chemical agents which inhibit the enzyme thymidylate synthase and have potential as an anticancer chemotherapy. This...
4 KB (380 words) - 10:51, 22 April 2024
(where uracil is used instead), inhibition of thymidine synthesis via thymidylate synthase selectively inhibits DNA synthesis over RNA synthesis. Due to their...
12 KB (1,314 words) - 05:55, 8 July 2024
Raltitrexed (category Thymidylate synthase inhibitors)
antimetabolite drug used in cancer chemotherapy. It is an inhibitor of thymidylate synthase, and is manufactured by AstraZeneca. Used in treatment of colorectal...
5 KB (311 words) - 21:24, 14 July 2024
In enzymology, a thymidylate synthase (FAD) (EC 2.1.1.148) is an enzyme that catalyzes the chemical reaction 5,10-methylenetetrahydrofolate + dUMP + FADH2...
3 KB (244 words) - 16:03, 26 August 2023
Fluorouracil (category Thymidylate synthase inhibitors)
entirely clear, but it is believed to involve blocking the action of thymidylate synthase and thus stopping the production of DNA. Fluorouracil was patented...
31 KB (2,796 words) - 07:50, 10 August 2024
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
31 KB (2,908 words) - 06:38, 22 September 2024
Capecitabine is metabolised to 5-FU which in turn is a thymidylate synthase inhibitor, hence inhibiting the synthesis of thymidine monophosphate...
14 KB (1,105 words) - 06:03, 14 September 2024
used instead. dTTP is synthesized via the methylation of dUMP via thymidylate synthase. It can be used by DNA ligase to create overlapping "sticky ends"...
3 KB (159 words) - 23:24, 17 July 2024
aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease...
40 KB (4,585 words) - 06:01, 23 September 2024
Kitamura H, Nomura N, Danenberg PV, Kubota Y (2005). "Expression of thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate...
28 KB (3,560 words) - 20:45, 22 July 2024
inhibited. Methotrexate, therefore, inhibits the synthesis of DNA, RNA, thymidylates, and proteins. For the treatment of rheumatoid arthritis, inhibition...
41 KB (3,770 words) - 03:37, 25 November 2024
2CCJ, 2CCK, 2PBR, 2TMK, 3TMK, 4TMK, and 5TMP. Thymidine kinase Thymidylate synthase Thymidine kinase in clinical chemistry Li C, Huang SH, Tang A, Drisco...
4 KB (350 words) - 06:28, 29 November 2023
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
38 KB (3,966 words) - 22:31, 11 November 2024
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
19 KB (1,757 words) - 09:15, 29 October 2024
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
31 KB (2,832 words) - 13:30, 20 September 2024
Fluorodeoxyuridylate (category Thymidylate synthase inhibitors)
5-fluorouracil and 5-fluorodeoxyuridine. FdUMP acts as a suicide inhibitor of thymidylate synthase (TS). By inhibiting the deoxynucleotide biosynthesis, FdUMP stops...
11 KB (1,304 words) - 20:08, 18 October 2024
methyl group onto the uracil base of dUMP to generate dTMP. The thymidylate synthase reaction, dUMP + 5,10-methylenetetrahydrofolate ⇔ dTMP + dihydrofolate...
61 KB (6,770 words) - 15:11, 20 August 2024
It bypasses several metabolic steps in the body and better binds thymidylate synthase with FdUMP, a metabolite of the drug fluorouracil. In March 2012...
15 KB (1,173 words) - 11:42, 25 June 2024
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
27 KB (2,575 words) - 07:01, 24 November 2024
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
39 KB (3,990 words) - 18:36, 16 October 2024
microscopy when prepared slide has a sample transversely dissected. Thymidylate synthase, the enzyme used to generate thymidine monophosphate Tourette syndrome...
3 KB (413 words) - 21:10, 1 September 2024
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
20 KB (1,870 words) - 00:52, 30 October 2024
the detoxification of formaldehyde. It is the one-carbon donor for thymidylate synthase, for methylation of 2-deoxy-uridine-5-monophosphate (dUMP) to...
6 KB (324 words) - 18:37, 28 April 2023
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
80 KB (9,540 words) - 22:21, 24 November 2024
therefore also inhibits DNA synthesis. It primarily inhibits the enzyme thymidylate synthase, but also has effects on DHFR, aminoimidazole carboxamide ribonucleotide...
155 KB (17,526 words) - 23:36, 26 October 2024
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
9 KB (716 words) - 15:15, 27 October 2024
purposes; rather, it enhances the effect of 5-fluorouracil by inhibiting thymidylate synthase. Folinic acid is also sometimes used to prevent toxic effects of...
18 KB (1,572 words) - 11:23, 8 October 2024
with the alpha-subunit of tryptophan (TSA) synthase to yield indole. The beta-subunit of tryptophan synthase (TSB) catalyzes condensation of indole with...
25 KB (2,510 words) - 13:39, 29 May 2024
targets. One of the important targets for cellular reproduction is thymidylate synthase, which creates thymidine monophosphate (TMP) from deoxyuridine monophosphate...
5 KB (638 words) - 02:17, 12 May 2024