In genetics, trinucleotide repeat disorders, a subset of microsatellite expansion diseases (also known as repeat expansion disorders), are a set of over...

A trinucleotide repeat expansion, also known as a triplet repeat expansion, is the DNA mutation responsible for causing any type of disorder categorized...

severity of symptoms is also noted. Anticipation is common in trinucleotide repeat disorders, such as Huntington's disease and myotonic dystrophy, where...

the most commonly observed manifestations of this process. Trinucleotide repeat disorders also follow a non-Mendelian pattern of inheritance. These diseases...

influenced by the sex of the affected parent. HD is one of several trinucleotide repeat disorders that are caused by the length of a repeated section of a gene...

called a trinucleotide repeat (for example: CAGCAGCAGCAG...), and abnormalities in such regions can give rise to trinucleotide repeat disorders. When between...

disorder in humans. Length changes in other triplet repeats are linked to more than 40 neurological diseases in humans, notably trinucleotide repeat disorders...

caused by expanded CAG repeats encoding polyglutamine (polyQ) stretches (see: Trinucleotide repeat disorder). The expanded CAG repeats create an adverse gain-of-function...

This disorder and finding of fragile X syndrome has an X-linked dominant inheritance. It is typically caused by an expansion of the CGG triplet repeat within...

disease in the person with the excess number of repeats. Fragile X syndrome, a trinucleotide repeat disorder, is a condition in which premutations may be...

(CTG) triplet repeats, termed trinucleotide repeat expansion and classifying DM1 as one of several trinucleotide repeat disorders. This expansion occurs...

frataxin. In 96% of cases, the mutant FXN gene has 90–1,300 GAA trinucleotide repeat expansions in intron 1 of both alleles. This expansion causes epigenetic...

chromosome extra, missing, or both (see chromosome abnormality) T – Trinucleotide repeat disorders: gene is extended in length "OMIM Entry - # 118220 - CHARCOT-MARIE-TOOTH...

as other repeat disorders. This hexanucleotide variant of a trinucleotide repeat disorder produces five different dipeptides by RAN translation, these...

diseases. Specifically, tandem repeat sequences, underlie several human disease conditions, particularly trinucleotide repeat diseases such as Huntington's...

Diseases associated with such mutations are known as trinucleotide repeat disorders. Polyglutamine repeats typically cause dominant pathogenesis. Extra glutamine...

with the increase in glutamine concentration. Isoglutamine Trinucleotide repeat disorder PolyQ tract "FDA approves new treatment for sickle cell disease"...

disorder linked to chromosome 4p15.3. It has only been reported in two families, and the causative gene is unidentified. Other neurogenetic disorders...

than that of trinucleotide repeat disorders, since D4Z4 repeats are much larger than trinucleotide repeats, an underabundance of repeats (rather than...

during the DNA synthesis step of DNA repair processes. Within DNA trinucleotide repeat sequences, the repair of DNA damage by the processes of homologous...

two disorders. SCA6 is caused by mutations in CACNA1A, a gene encoding a calcium channel α subunit. These mutations tend to be trinucleotide repeats of...

class of autosomal and X-linked dominant diseases known as trinucleotide repeat disorders (for example, Huntington's disease), a molecular mechanism for...

be associated with post-stroke hyperkinesia. DRPLA is a rare trinucleotide repeat disorder (polyglutamine disease) that can be juvenile-onset (< 20 years)...

times, give rise to numerous known diseases, including the trinucleotide repeat disorders. Robert I. Richards and Grant R. Sutherland called these phenomena...

part of a class of neurodegenerative disorders known as trinucleotide repeat disorders or polyglutamine disorders. The key sequence which is found in Huntington's...

biological database of polyglutamine repeats in disease and non-disease associated proteins. Trinucleotide repeat disorder Robertson, Amy L; Bate Mark A; Androulakis...

can occur in some cases. It is caused by an expanded number of trinucleotide repeats in the polyglutamine tract of the ATXN1 gene, which encodes the...

Sierra Leone CGG, a codon for the amino acid arginine CGG repeats, a trinucleotide repeat disorder; causing: Fragile X syndrome Fragile X-associated tremor/ataxia...

0b013e328356d328. PMID 22918486. Orr HT, Zoghbi HY (July 2007). "Trinucleotide repeat disorders". Annual Review of Neuroscience. 30 (1): 575–621. doi:10.1146/annurev...

SMRT sequencing. This is an example of a Trinucleotide repeat disorder. Trinucleotide repeat expansion is likely a consequence of strand slippage either...