U.S. Route 74 (US 74) is an east–west United States highway that runs for 515 miles (829 km) from Chattanooga, Tennessee to Wrightsville Beach, North Carolina...

Several special routes of U.S. Route 74 exist. In order from west to east they are as follows. U.S. Route 74 Alternate (US 74A) was established in 1994...

U.S. Route 221 (US 221) is a 734-mile-long (1,181 km) spur of U.S. Route 21. It travels from Perry, Florida, at US 19/US 98/US 27 Alternate to Lynchburg...

U.S. Route 136 is an east-west U.S. highway that is a spur route of U.S. Route 36. It runs from Edison, Nebraska, at U.S. Route 6 and U.S. Route 34 to...

U.S. Route 441 (US 441) is a 939-mile-long (1,511 km) auxiliary route of U.S. Route 41. It extends from US 41 in Miami, Florida to US 25W in Rocky Top...

U.S. Route 150 (US 150) is a 571-mile (919 km) long northwest–southeast United States highway, signed as east–west. It runs from U.S. Route 6 outside...

U.S. Route 9 (US 9) is a north–south United States Numbered Highway in the states of Delaware, New Jersey, and New York in the Northeastern United States...

U.S. Route 501 (US 501) is a spur of U.S. Route 1. It runs 355 miles (571 km) from Buena Vista, Virginia at U.S. Route 60 to Myrtle Beach, South Carolina...

U.S. Route 6 (US 6) or U.S. Highway 6 (US 6), also called the Grand Army of the Republic Highway, honoring the American Civil War veterans association...

U.S. Route 76 (US 76) is an east–west U.S. highway in the Southeastern United States that travels for 548 miles (882 km). Its western terminus is at US...

U.S. Route 1 or U.S. Highway 1 (US 1) is a major north–south United States Numbered Highway that serves the East Coast of the United States. It runs 2...

U.S. Route 421 (also U.S. Highway 421, US 421) is a diagonal northwest–southeast United States Numbered Highway in the states of North Carolina, Tennessee...

U.S. Route 601 (US 601) is a north–south United States highway that runs for 316.3 miles (509.0 km) from U.S. Route 321, near Tarboro, South Carolina...

U.S. Route 17 or U.S. Highway 17 (US 17), also known as the Coastal Highway, is a north–south United States Numbered Highway that spans in the Southeastern...

U.S. Route 89A is a 91.74-mile (147.64 km) north–south auxiliary U.S. highway (though its actual direction of travel is more east–west) in southwestern...

U.S. Route 64 (US 64) is an east–west United States highway that runs for 2,281 miles (3,672 km) from Nags Head in eastern North Carolina to just southwest...

U.S. Route 31 or U.S. Highway 31 (US 31) is a major north–south U.S. highway connecting southern Alabama to northern Michigan. Its southern terminus is...

U.S. Route 19 or U.S. Highway 19 (US 19) is a north–south United States Numbered Highway in the Eastern United States. Despite encroaching Interstate Highways...

U.S. Route 70 or U.S. Highway 70 (US 70) is an east–west United States highway that runs for 2,381 miles (3,832 km) from eastern North Carolina to east-central...

U.S. Route 34 (US 34) is an east–west United States highway that runs for 1,122 miles (1,806 km) from north-central Colorado to the western suburbs of...

U.S. Route 52 (US 52) is a major United States highway in the central United States that extends from the northern to southeastern region of the United...

U.S. Route 220 (US 220) is a spur route of US 20. It runs in a north–south layout in the eastern United States, unlike its parent route as well as conventionally...

U.S. Route 191 (US 191) is a north–south highway in the Western United States and a spur of parent route U.S. Route 91 that has two segments. The southern...

and Wilmington. US 76 runs concurrently with US 17 along much of its Wilmington routing, until once again meeting US 74. US 76 and US 74 run concurrently...

U.S. Route 29 or U.S. Highway 29 (US 29) is a north–south United States Numbered Highway that runs for 1,043.3 miles (1,679.0 km) from Pensacola, Florida...

U.S. Route 129 (US 129) is an auxiliary route of US 29, which it intersects in Athens, Georgia. US 129 currently runs for 582 miles (937 km) from an intersection...

U.S. Route 301 (US 301) is a spur of U.S. Route 1 running through the South Atlantic states. It runs 1,099 miles (1,769 km) from Biddles Corner, Delaware...

U.S. Route 23 or U.S. Highway 23 (US 23) is a major north–south United States Numbered Highway between Jacksonville, Florida, and Mackinaw City, Michigan...

AASHTO to remove US 311 from the southernmost 37 miles (60 km) of the route, being mostly redundant to I-74, bringing it to its current routing from Winston-Salem...

U.S. Route 15 or U.S. Highway 15 (US 15) is a 791.71-mile-long (1,274.13 km) United States Numbered Highway, serving the states of South Carolina, North...