The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress. It has been found to be conserved...

mitochondrial unfolded protein response (UPRmt) is a cellular stress response related to the mitochondria. The UPRmt results from unfolded or misfolded proteins in...

specific effects on virulence. A number of studies found that the unfolded protein response contributes to virulence of A. fumigatus. The lifecycle of filamentous...

degradation processes. When proteins are determined to be unfolded or misfolded, they are typically degraded via the unfolded protein response (UPR) or...

of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast". Biochemical and Biophysical Research Communications...

correctly. This pathway is termed the unfolded protein response (UPR). However, how cells sense misfolded proteins and relays this information to the cell...

UPR may refer to: Unfolded protein response, a biological response in the "endoplasmic reticulum" when some proteins did not properly fold Union Pacific...

between unfolded protein response (UPR) responses and autophagy, oxidative stress, and inflammatory response signals in ER stress: aggregation of unfolded/misfolded...

stress response and the unfolded protein response (UPR). Conditions that exceed capacity of the ER provoke ER stress and trigger the unfolded protein response...

unfolded protein response, its disruption could be linked with neurodegenerative diseases, wherein the accumulation of intracellular toxic proteins serves...

folded proteins are transported from the rough ER to the Golgi apparatus – unfolded proteins cause an unfolded protein response as a stress response in the...

in the accumulation of misfolded proteins. As there is a high level of misfolded protein, unfolded protein response (UPR) is stimulated and lead to transcriptional...

stress-induced death. It exerts this action by binding to ERN1, the unfolded protein response (UPR) sensor in the ER, which results in the attenuation of UPR...

triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression...

JA, Eyholzer M, Timchenko NA, Mueller BU, Pabst T (Jun 2010). "Unfolded protein response suppresses CEBPA by induction of calreticulin in acute myeloid...

"Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-β induction via X-box binding protein 1". European Journal of Immunology...

Exercise-induced PGC-1α in skeletal muscle increases autophagy and unfolded protein response. PGC-1α protein may also be involved in controlling blood pressure, regulating...

of ER calcium stores leads to ER stress and activation of the unfolded protein response. Non-resolved ER stress can cumulatively lead to cell death. Prolonged...

1958) is a Japanese molecular biologist known for research on unfolded protein response. He is a professor of Biophysics at the Graduate School of Science...

researched, with the main hypotheses being mislocalization of ELANE or unfolded protein response (UPR) induced by mutant ELANE, however according to Mehta et al...

ATF/cAMP response elements and ER stress-response elements, binding the promoters and inducing transcription of several genes involved in unfolded protein response...

causes the protein to be misfolded, initiating the unfolded protein response (UPR), a pro-inflammatory endoplasmic reticulum (ER) stress response. Although...

eIF2α. ER stress caused by excess of unfolded proteins leads to inflammatory responses. PKR contributes to this response by interacting with several inflammatory...

sensitive to endoplasmic reticulum (ER) stress and the subsequent unfolded protein response (UPR). Severe or prolonged episodes of ER stress can lead to the...

Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. BAX is a member of the Bcl-2 gene...

necessary for protein folding, so skin cells may initiate the unfolded protein response which releases cytokines, thus mounting an immune response The National...

cells and other systems, and as such induces ER stress and the Unfolded Protein Response (UPR) pathway. 2-DG has been used as a targeted optical imaging...

mammary tumors as part of the unfolded protein response. Derlin-1 has been shown to interact with the following proteins: HRD1 VIMP US11 Derlin-2 Derlin-3...

Parkin is a 465-amino acid residue E3 ubiquitin ligase, a protein that in humans and mice is encoded by the PARK2 gene. Parkin plays a critical role in...

Dissection of the Unfolded Protein Response” the researchers suppressed multiple genes in each cell to study the unfolded protein response (UPR) pathway....