the protein-tyrosine kinase family and is a close homolog of SYK. SYK and ZAP70 share a common evolutionary origin and split from a common ancestor in the...
23 KB (2,769 words) - 14:27, 11 December 2023
ZAP70 deficiency, or ZAP70 deficient SCID, is a rare autosomal recessive form of severe combined immunodeficiency (SCID) resulting in a lack of CD8+ T...
3 KB (282 words) - 15:13, 27 October 2023
phosphorylates the zeta chain of the T-cell receptor, subsequently another nRTK, Zap70, binds to this T-cell receptor and then participates in downstream signaling...
21 KB (2,716 words) - 15:11, 26 August 2023
TCR and to recruit and activate the ζ-chain- associated protein Zap70 activated Zap70 in turn phosphorylates the membrane adaptor Lat, which subsequently...
9 KB (1,147 words) - 07:16, 18 July 2023
V W X Y Z See also Health Exercise Nutrition Zadik–Barak–Levin syndrome ZAP70 deficiency Zamzam–Sheriff–Phillips syndrome Zechi-Ceide syndrome Zellweger...
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recruit protein tyrosine kinase Zap70 that can bind to the phosphorylated tyrosine residues with its SH2 domain. This brings Zap70 into close proximity to Lck...
43 KB (5,370 words) - 03:09, 26 June 2024
production and T cell proliferation. The mechanism involves inhibition of ZAP70 phosphorylation and its association with CD3ζ. PD-1 signaling attenuates...
25 KB (3,073 words) - 13:49, 19 July 2024
kinases than ZAP70. SYK and ZAP70 share a common evolutionary origin and split from a common ancestor in the jawed vertebrates. While Syk and ZAP70 are primarily...
18 KB (2,083 words) - 06:18, 25 December 2023
activate SH2 domain-containing protein tyrosine kinases (PTK), such as ZAP70, to further mediate downstream signalling through tyrosine phosphorylation...
22 KB (2,581 words) - 20:03, 21 June 2024
the ITAM on CD3 renders the CD3 chain capable of binding an enzyme called ZAP70 (zeta associated protein), a kinase that is important in the signaling cascade...
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BRK SRMS JAK family JAK1 JAK2 JAK3 TYK2 SRC-A family SRC FGR FYN YES1 SRC-B family BLK HCK LCK LYN TEC family TEC BMX BTK ITK TXK SYK family SYK ZAP70...
43 KB (4,651 words) - 13:41, 27 July 2024
with hypereosinophilia. The list of such disorders includes ZAP70 deficiency (defective ZAP70 gene), CD3gamma chain deficiency (defective CD3G gene), MCHII...
50 KB (5,494 words) - 21:49, 19 July 2024
for the SH2 domain of the SYK family kinase ZAP70, which is there phosphorylated too. The Phosphorylated ZAP70 then propagate a signal from a TCR, phosphorylating...
33 KB (3,897 words) - 01:20, 14 June 2024
is recruited and phosphorylates the ITAMs of the CD3 cytoplasmic tail. ZAP70 is then recruited to the phosphorylated ITAMs and helps recruit LAT and...
89 KB (9,817 words) - 08:00, 10 June 2024
SUPT6H; SYK TEC; TENC1; TNS; TNS1; TNS3; TNS4; TXK VAV1; VAV2; VAV3 YES1; ZAP70 Phosphotyrosine-binding domains also bind phosphorylated tyrosines Anthony...
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PLC-gamma-2 Defective BCR signaling PI3K Impaired B and T cell homeostasis ZAP70 Impaired T cell function TLR7 and TLR9 Defects in B cells activation in...
35 KB (3,368 words) - 18:35, 1 July 2024
SYK; TEC; TEK; TEX14; TIE1; TNK1; TNK2; TNNI3K; TXK; TYK2; TYRO3; YES1; ZAP70 Tyrphostins Bcr-Abl tyrosine kinase inhibitors BYKdb Hanks SK, Quinn AM...
43 KB (5,251 words) - 10:44, 24 June 2024
responsiveness to the antigen pigeon cytochrome c peptide, as determined by ZAP70 phosphorylation, proliferation, and interleukin 2 production. Thus Stefanova...
50 KB (5,851 words) - 16:28, 29 July 2024
BRK SRMS JAK family JAK1 JAK2 JAK3 TYK2 SRC-A family SRC FGR FYN YES1 SRC-B family BLK HCK LCK LYN TEC family TEC BMX BTK ITK TXK SYK family SYK ZAP70...
60 KB (6,879 words) - 14:26, 16 July 2024
DAP12 bears ITAM motif and activates protein tyrosine kinases Syk and Zap70 signalling. NKG2D ligands are induced-self proteins which are completely...
31 KB (3,695 words) - 20:24, 13 October 2022
(2017-07-07). "Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes". Frontiers in Immunology...
4 KB (462 words) - 00:51, 6 July 2023
ζ-chain of the T-cell receptor (TCR) to CBL, WASP, p38, LCK, VAV1, and ZAP70. This data suggests that DLG1 plays a role in linking TCR signaling machinery...
25 KB (2,159 words) - 11:01, 3 August 2024
BRK SRMS JAK family JAK1 JAK2 JAK3 TYK2 SRC-A family SRC FGR FYN YES1 SRC-B family BLK HCK LCK LYN TEC family TEC BMX BTK ITK TXK SYK family SYK ZAP70...
8 KB (827 words) - 22:08, 3 December 2023
BRK SRMS JAK family JAK1 JAK2 JAK3 TYK2 SRC-A family SRC FGR FYN YES1 SRC-B family BLK HCK LCK LYN TEC family TEC BMX BTK ITK TXK SYK family SYK ZAP70...
22 KB (2,389 words) - 06:43, 22 April 2024
BRK SRMS JAK family JAK1 JAK2 JAK3 TYK2 SRC-A family SRC FGR FYN YES1 SRC-B family BLK HCK LCK LYN TEC family TEC BMX BTK ITK TXK SYK family SYK ZAP70...
9 KB (974 words) - 14:46, 22 June 2024
BRK SRMS JAK family JAK1 JAK2 JAK3 TYK2 SRC-A family SRC FGR FYN YES1 SRC-B family BLK HCK LCK LYN TEC family TEC BMX BTK ITK TXK SYK family SYK ZAP70...
10 KB (1,215 words) - 03:15, 19 April 2024
BRK SRMS JAK family JAK1 JAK2 JAK3 TYK2 SRC-A family SRC FGR FYN YES1 SRC-B family BLK HCK LCK LYN TEC family TEC BMX BTK ITK TXK SYK family SYK ZAP70...
35 KB (4,117 words) - 14:30, 7 July 2024
BRK SRMS JAK family JAK1 JAK2 JAK3 TYK2 SRC-A family SRC FGR FYN YES1 SRC-B family BLK HCK LCK LYN TEC family TEC BMX BTK ITK TXK SYK family SYK ZAP70...
8 KB (755 words) - 18:51, 2 November 2023
BRK SRMS JAK family JAK1 JAK2 JAK3 TYK2 SRC-A family SRC FGR FYN YES1 SRC-B family BLK HCK LCK LYN TEC family TEC BMX BTK ITK TXK SYK family SYK ZAP70...
28 KB (3,078 words) - 07:46, 3 June 2024
BRK SRMS JAK family JAK1 JAK2 JAK3 TYK2 SRC-A family SRC FGR FYN YES1 SRC-B family BLK HCK LCK LYN TEC family TEC BMX BTK ITK TXK SYK family SYK ZAP70...
21 KB (2,648 words) - 12:12, 26 July 2024