Aldosterone synthase, also called steroid 18-hydroxylase, corticosterone 18-monooxygenase or P450C18, is a steroid hydroxylase cytochrome P450 enzyme involved...
21 KB (2,347 words) - 00:25, 10 July 2024
18-hydroxylation functions), but aldosterone synthase is also able to perform an 18-oxidation. Moreover, aldosterone synthase is found within the zona glomerulosa...
32 KB (3,377 words) - 13:20, 24 January 2024
aldosteronism also describable as aldosterone synthase hyperactivity, is an autosomal dominant disorder in which the increase in aldosterone secretion produced by...
8 KB (846 words) - 14:26, 27 October 2023
enzyme aldosterone synthase (also known as CYP11B2). Aldosterone is largely responsible for the long-term regulation of blood pressure. Aldosterone's effects...
13 KB (1,476 words) - 20:50, 17 July 2024
Hypoaldosteronism (redirect from Aldosterone defiency)
inhibitors. Primary aldosterone deficiency Primary adrenal insufficiency Congenital adrenal hyperplasia (21 but not 11β and 17) Aldosterone synthase deficiency...
7 KB (629 words) - 13:13, 9 March 2024
Spironolactone (category Aldosterone synthase inhibitors)
3β-hydroxysteroid dehydrogenase, 11β-hydroxylase, 21-hydroxylase, and aldosterone synthase (18-hydroxylase). However, although very high doses of spironolactone...
181 KB (17,339 words) - 07:09, 27 August 2024
that is being evaluated for the treatment of hypertension. It is an aldosterone synthase inhibitor. "Baxdrostat - CinCor Pharma". AdisInsight. Springer Nature...
5 KB (116 words) - 09:44, 24 April 2024
main site for production of aldosterone, a mineralocorticoid, by the action of the enzyme aldosterone synthase. Aldosterone plays an important role in...
49 KB (5,621 words) - 22:06, 4 August 2024
18-hydroxylation functions), but aldosterone synthase is also able to perform an 18-oxidation. Moreover, aldosterone synthase is found within the zona glomerulosa...
41 KB (4,147 words) - 01:54, 20 July 2024
Primary aldosteronism (redirect from Aldosterone-Producing Adenoma)
primary hyperaldosteronism, refers to the excess production of the hormone aldosterone from the adrenal glands, resulting in low renin levels and high blood...
30 KB (2,996 words) - 05:10, 25 July 2024
excretion, increase water reabsorption through osmosis. The enzyme aldosterone synthase (also known as CYP11B2) acts in this location The expression of neuron-specific...
8 KB (714 words) - 14:41, 20 October 2023
Lorundrostat (category Aldosterone synthase inhibitors)
Lorundrostat (developmental name MLS 101) is an aldosterone synthase inhibitor developed by Mineralys Therapeutics for high blood pressure. In clinical...
6 KB (352 words) - 02:45, 20 March 2024
hydroxylated via 11β-hydroxylase (CYP11B1) and to a lesser extent via aldosterone synthase (CYP11B2) into 11β-hydroxyprogesterone. In addition, progesterone...
123 KB (11,581 words) - 15:07, 12 August 2024
expressed at high levels and is regulated by ACTH, while CYP11B2 (aldosterone synthase) is usually expressed at low levels and is regulated by angiotensin...
24 KB (2,630 words) - 22:31, 10 April 2024
Mitotane (category Aldosterone synthase inhibitors)
CYP11A1), and also of 11β-hydroxylase (CYP11B1), 18-hydroxylase (aldosterone synthase, CYP11B2), and 3β-hydroxysteroid dehydrogenase (3β-HSD) to a lesser...
11 KB (834 words) - 16:34, 24 July 2024
cleavage enzyme; P450scc) CYP11B1 (steroid 11β-hydroxylase) CYP11B2 (aldosterone synthase) CYP17A1 (steroid 17α-hydroxylase/17,20-lyase) CYP19A1 (aromatase)...
9 KB (78 words) - 09:09, 12 November 2023
11β-hydroxylase (CYP11B1) enzyme, and, to a lesser extent, by the aldosterone synthase enzyme (CYP11B2). Along with its epimer 11α-hydroxyprogesterone (11α-OHP)...
14 KB (1,490 words) - 00:15, 11 April 2024
and are used in the diagnosis and treatment of Cushing's syndrome. Aldosterone synthase (CYP11B2) inhibitors such as metyrapone, mitotane, and osilodrostat...
37 KB (2,107 words) - 17:27, 8 June 2024
Aminoglutethimide (category Aldosterone synthase inhibitors)
cortisol, respectively. Aldosterone synthase (18-hydroxylase; CYP11B2). Prevents the conversion of corticosterone into aldosterone. As such, AG is an estrogen...
32 KB (2,828 words) - 01:55, 30 November 2023
called aldosterone synthase, which helps produce aldosterone. When CYP11B1 and CYP11B2 are abnormally fused together, too much aldosterone synthase is produced...
6 KB (605 words) - 12:10, 25 July 2024
17α-Hydroxylase – androgen and glucocorticoid synthesis 18-Hydroxylase (aldosterone synthase) – mineralocorticoid synthesis 21-Hydroxylase – corticosteroid synthesis...
6 KB (504 words) - 03:45, 23 November 2023
In primary aldosteronism there is a clear relationship between the aldosterone-induced sodium retention and the hypertension. Congenital adrenal hyperplasia...
39 KB (3,988 words) - 15:13, 10 August 2024
Osilodrostat (category Aldosterone synthase inhibitors)
syndrome). It specifically acts as a potent and selective inhibitor of aldosterone synthase (CYP11B2) and at higher dosages of 11β-hydroxylase (CYP11B1). In...
13 KB (1,022 words) - 09:37, 20 July 2024
sampling. In aldosterone-producing adrenocortical adenoma (APA), which is the main cause of primary aldosteronism, the enzyme aldosterone synthase (CYP11B2)...
6 KB (565 words) - 13:51, 22 August 2024
by 11β-hydroxylase. Corticosterone is then converted to aldosterone by aldosterone synthase. Most of the DOC is secreted by the zona fasciculata of the...
20 KB (2,168 words) - 15:31, 27 June 2024
adrenocortical cells, downregulating aldosterone synthase, CYP11B1, and the production of adrenal steroids (i.e. aldosterone and cortisol). Glutamate does not...
35 KB (3,215 words) - 04:31, 25 July 2024
in part be mediated by direct inactivation of 11β-hydroxylase and aldosterone synthase (18-hydroxylase), enzymes involved in the biosynthesis of mineralocorticoids...
97 KB (10,979 words) - 00:19, 8 July 2024
18-Hydroxycorticosterone serves as an intermediate in the synthesis of aldosterone by the enzyme aldosterone synthase in the zona glomerulosa. It is also an intermediate...
6 KB (436 words) - 18:11, 6 April 2024
Pseudohyperaldosteronism Glucocorticoid-remediable aldosteronism Aldosterone and aldosterone synthase Maria New Palermo, Mario; Quinkler, Marcus; Stewart, Paul...
12 KB (1,131 words) - 13:21, 9 March 2024
Efonidipine (category Aldosterone synthase inhibitors)
excretion from the kidneys by suppressing aldosterone synthesis and secretion from the adrenal glands. Aldosterone induced renal parenchymal fibrosis is suppressed...
15 KB (1,414 words) - 04:38, 9 January 2024