homolog is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function...

subunit, CDC20 allows APC to degrade substrates such as anaphase inhibitors (Pdsp1) at the beginning of anaphase, on the other hand when CDC20 is substituted...

human cells, binding of BUBR1 to CDC20 requires prior binding of MAD2 to CDC20, so it is possible that the MAD2-CDC20 subcomplex acts as an initiator for...

Prophase Prometaphase Metaphase Telophase Cytoskeleton Anaphase I Anaphase II Cdc20 "Chromosome condensation through mitosis". Science Daily. Retrieved 12 June...

include either Cdc20 or Mad1. Mad1 and Cdc20 bind Mad2 in an identical fashion. Mad2 uses the same site to bind either Mad1 or Cdc20 and, thus, can only...

association with Cdc20 (APC-Cdc20) ubiquitinates and targets mitotic cyclins (Clb2) for degradation at initial phase. Simultaneously, APC-Cdc20 mediates degradation...

complex (APC), also known as the cyclosome, a ubiquitin-ligase. The active, CDC20-bound APC (APC/CCDC20) targets mitotic cyclins for degradation starting...

stage of the cell cycle. Cytokinesis happens only after APC binds with CDC20.[citation needed] This allows for the separation of chromosomes and myosin...

essential for Mad2-Cdc20 complex formation in vivo but not in vitro. In vivo, Mad1 acts as a competitive inhibitor of the Mad2-Cdc20 complex. Mad1 is phosphorylated...

structure of mad1-mad2 reveals a conserved mad2 binding motif in mad1 and cdc20. Identifiers Symbol HORMA Pfam PF02301 InterPro IPR003511 SCOP2 1duj / SCOPe...

Cdh1 (cdc20 homolog 1) is one of the substrate adaptor proteins of the anaphase-promoting complex (APC) in the budding yeast Saccharomyces cerevisiae...

ligase responsible for triggering events of late mitosis. In early mitosis, Cdc20 levels rise and APC/C binds to form active APC/CCdc20. This then leads to...

to chromosome 14. MAD2L1 has been shown to interact with: ADAM17, BUB1B, CDC20, CDC27 and Estrogen receptor beta, MAD2L2, Mad1, and UBD. GRCh38: Ensembl...

unattached kinetochores, a complex consisting of BubR1, Bub3, and Cdc20 interact with the Mad2-Cdc20 complex to inhibit the APC, thus inhibiting the formation...

"cell division cycle") followed by an identifying number, e.g. cdc25 or cdc20. Cyclins form the regulatory subunits and CDKs the catalytic subunits of...

moment, the checkpoint proteins that bind to and inhibit Cdc20 (Mad1-Mad2 and BubR1), release Cdc20, which binds and activates APC/CCdc20, and this complex...

activation of the SAC Bub1 directly phosphorylates APC/C's coactivator Cdc20. This phosphorylation event is probably achieved in complex with Bub3, which...

CRT resistance. BUB1B has been shown to interact with: AP2B1 BRCA2 BUB3 CDC20 MAD2L1 CBP SIRT2 PLK1 PP2A-B56 HDAC1 HDAC2 / HDAC3 SNCG GRCh38: Ensembl...

to Cdc20 (APC/C-cdc20) marks Securin (anaphase inhibitor) for degradation by the proteasome. Securin is cleaved at anaphase, following APC/C-cdc20 mediated...

"Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology. 8 (22): 1207–S4. Bibcode:1998CBio....8.1207K...

Centre, former hospital in Novena, Singapore Cell-division cycle in biology cdc20 cdc25 Cdc42, cell-division cycle protein Cholesterol-dependent cytolysin...

cell-specific centrosomal protein associated with the seventh WD motif of Cdc20". The Journal of Biological Chemistry. 279 (40): 42128–38. doi:10.1074/jbc...

HGNC:1719 O60729 2590 CDC14C HGNC:22427 A4D256 2591 CDC16 HGNC:1720 Q13042 2592 CDC20 HGNC:1723 Q12834 2593 CDC20B HGNC:24222 Q86Y33 2594 CDC23 HGNC:1724 Q9UJX2...

binding of CDC20 to APC/C is required for the ubiquitination of securin. A protein called hMAD2 can form an inactive trimer with APC and CDC20, forming...

protein 1 subunit gamma CCT6A CCT6A T-complex protein 1 subunit zeta CDC20 CDC20 Cell Division Cycle 20 CDC37 CDC37 Cell Division Cycle 37 CDC5L CDC5L...

interact with: ANAPC10, ANAPC11, ANAPC1, ANAPC4, ANAPC5, ANAPC7, CDC16, CDC20, CDC23, CDH1, FZR1, MAD2L1 and PIN1. GRCh38: Ensembl release 89: ENSG00000004897...

checkpoint complex which is composed of four different proteins known as Mad2, Cdc20, BubR1, and Bub3 in humans. When the mitotic checkpoint complex is formed...

Prosperini E, Helin K, Musacchio A (November 2001). "Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint". The...

independent research careers". As a Whitehead Fellow, her team discovered that CDC20 plays a crucial role in cell division. Her Whitehead team identified an...

is recognized by the Anaphase-Promoting Complex (APC) bound primarily to Cdc20 (Cdh1 is also an activating substrate of APC). The APCCdc20 complex ubiquitinates...