Ceritinib (INN, trade name Zykadia /zaɪˈkeɪdiːə/ zy-KAY-dee-ə) is a prescription-only drug used for the treatment of non-small cell lung cancer (NSCLC)...
16 KB (1,264 words) - 12:39, 14 June 2024
LDK may refer to: Ceritinib or LDK378, a drug used for the treatment non-small cell lung cancer L.D.K. Lounge Designers Killer, a 2005 album by Japanese...
1 KB (152 words) - 22:11, 23 February 2021
ALK inhibitors crizotinib, or its successors alectinib, brigatinib, and ceritinib. Those treated with ALK inhibitors who relapse can then be treated with...
90 KB (9,784 words) - 14:55, 21 June 2024
and targeting a broader set of resistance mutations. As such, Novartis' ceritinib was approved by the FDA in April 2014 for treatment of NSCLC. It provided...
17 KB (1,951 words) - 10:39, 25 January 2024
brand name Xalkori and Crizalk that targets the EML4/ALK fusion gene. Ceritinib is a second generation targeted therapy (FDA approved in 2014), manufactured...
15 KB (1,597 words) - 20:20, 8 July 2024
Pembrolizumab Merck Sharp & Dohme microsatellite instability-high tumors Ceritinib Novartis Pharmaceuticals ALK-positive, metastatic non-small cell lung...
34 KB (180 words) - 22:09, 8 April 2024
for metastatic disease or whose disease has progressed on alectinib or ceritinib as the first ALK inhibitor therapy for metastatic disease. Approval was...
19 KB (1,435 words) - 22:27, 16 June 2024
days of treatment. Treatment must be continued indefinitely at present. Ceritinib was approved by the FDA in April 2014 for the treatment of patients with...
48 KB (5,299 words) - 01:24, 9 March 2024
Sorafenib Sunitinib Tivozanib Toceranib Vandetanib ALK Alectinib Brigatinib Ceritinib RET inhibitors: Entrectinib (ALK, ROS1, NTRK), Futibatinib (FGFR2), Infigratinib...
12 KB (760 words) - 03:40, 23 July 2024
metronidazole (antibiotic and antiprotozoal medication) phenylbutazone Weak ceritinib quercetin (a plant-based flavonol) Unspecified potency antihistamines...
50 KB (5,023 words) - 03:04, 8 April 2024
as those increasing the AUC of digoxin to ≥1.25-fold); telithromycin ceritinib mibefradil (used for the treatment of hypertension and chronic angina...
80 KB (7,794 words) - 21:26, 15 July 2024
Sorafenib Sunitinib Tivozanib Toceranib Vandetanib ALK Alectinib Brigatinib Ceritinib RET inhibitors: Entrectinib (ALK, ROS1, NTRK), Futibatinib (FGFR2), Infigratinib...
12 KB (758 words) - 23:46, 14 March 2024
Vemurafenib L01EC02 Dabrafenib L01EC03 Encorafenib L01ED01 Crizotinib L01ED02 Ceritinib L01ED03 Alectinib L01ED04 Brigatinib L01ED05 Lorlatinib L01EE01 Trametinib...
12 KB (877 words) - 15:36, 25 January 2024
certain resistance mutations that develop during treatment with crizotinib. Ceritinib demonstrates clinical activity (including treating the brain) in ROS1+...
29 KB (3,680 words) - 06:37, 4 September 2023
crizotinib benefited from second-generation ALK inhibitors including ceritinib, alectinib and brigatinib. Resistance to ALK inhibitors can occur with...
42 KB (4,603 words) - 20:35, 17 July 2024
the development of multiple new drug launches, for example nilotinib, ceritinib, panobinostat, and Entresto. Briner left Novartis in late 2022, and is...
4 KB (397 words) - 22:00, 23 January 2024
CH5424802 (Chugai Pharmaceutical Co.) ASP3026 (Astellas Pharma Inc.) Ceritinib (LDK378, Novartis Pharmaceuticals) AP26113 (Ariad Pharmaceuticals) Crizotinib...
12 KB (1,460 words) - 10:50, 17 October 2021
retreatment with crizotinib (1 case) or a second generation ALK inhibitor, ceritinib (1 case). A study of 14 pediatric patients with metastatic or inoperable...
33 KB (3,914 words) - 20:05, 30 August 2023