A circadian clock, or circadian oscillator, also known as one’s internal alarm clock is a biochemical oscillator that cycles with a stable phase and is...

the environment (is entrained by the environment). Circadian rhythms are regulated by a circadian clock whose primary function is to rhythmically co-ordinate...

These biological clocks control processes that fluctuate daily (e.g., body temperature, alertness, hormone secretion), generating circadian rhythms. Among...

CLOCK (backronym for circadian locomotor output cycles kaput) is a gene encoding a basic helix-loop-helix-PAS transcription factor that is known to affect...

in the function of the endocrine and immune systems. The internal circadian clock promotes sleep daily at night. The diverse purposes and mechanisms...

oscillators (see Circadian rhythm) in mammals are sensitive to temperature pulses and will experience resetting of the circadian clock phase and associated...

generating molecular circadian rhythms. Research has revealed that BMAL1 is the only clock gene without which the circadian clock fails to function in...

Translation Negative Feedback Loop for circadian clocks in 1990. In 1998, they discovered the cycle gene, clock gene, and cryptochrome photoreceptor in...

discovery was a result of the Clock Genome Project, which uses "forward genetics" to discover the genes regulating circadian clocks in mice, fruit flies, and...

and mammal-like (Type II). CRY1 is a circadian photoreceptor whereas CRY2 is a clock repressor which represses Clock/Cycle (Bmal1) complex in insects and...

not for circadian rhythmicity. It also works independently as a target of the BMAL1/CLOCK complex. The E-box plays an important role in circadian genes;...

central role in the molecular mechanism of the Drosophila biological clock driving circadian rhythms in eclosion and locomotor activity. Mutations in the per...

zeitgeber, influence the timing of these internal clocks. Light (light is the most potent regulator of circadian rhythms). Atmospheric conditions Medication...

corticotropin-releasing hormone), and genes involved in the mammalian circadian clock (PER1, PER2). CREB is closely related in structure and function to...

central and peripheral clocks. Similarly to how circadian clocks operate in Drosophila and mammals, the monarch circadian clock uses a transcription translation...

Bacterial circadian rhythms, like other circadian rhythms, are endogenous "biological clocks" that have the following three characteristics: (a) in constant...

Period circadian protein homolog 1 is a protein in humans that is encoded by the PER1 gene. The PER1 protein is important to the maintenance of circadian rhythms...

1966 to test whether humans, like other species, have an intrinsic circadian clock. It was started by Jürgen Aschoff and Rütger Wever of the Max Planck...

group discovered the genetic basis for the mammalian circadian clock in 1994 and identified the Clock gene in 1997. Takahashi was elected to the National...

Non-24-hour sleep–wake disorder (non-24 or N24SWD) is one of several chronic circadian rhythm sleep disorders (CRSDs). It is defined as a "chronic steady pattern...

sleep–wake phase disorder, is the delaying of a person's circadian rhythm (biological clock) compared to those of societal norms. The disorder affects...

biologist specializing in DNA repair, cell cycle checkpoints, and circadian clock. In 2015, he was awarded the Nobel Prize in Chemistry along with Tomas...

by shift work and circadian rhythm sleep disorders. When travelling across a number of time zones, a person's body clock (circadian rhythm) will be out...

positionally cloned the Drosophila Clock gene. In his laboratory at Northwestern, he discovered a conserved mechanism for circadian control of sleep-wake cycle...

molecular biology, the cyanobacterial clock proteins are the main circadian regulator in cyanobacteria. The cyanobacterial clock proteins comprise three proteins:...

that keep cells on a roughly 24-hour schedule. This oscillator, or "circadian clock," is made up of a transcription-translation feedback loop (TTFL) in...

of sleep and melatonin levels are regulated by the body's central circadian clock, which is located in the suprachiasmatic nucleus in the hypothalamus...

Circadian Clock Associated 1 (CCA1) is a gene that is central to the circadian oscillator of angiosperms. It was first identified in Arabidopsis thaliana...

Light effects on circadian rhythm are the response of circadian rhythms to light. Most animals and other organisms have a biological clock that synchronizes...

Jay Dunlap include his work investigating the role of frq and wc clock genes in circadian rhythmicity, and his leadership in coordinating the whole genome...