Cyclooxygenase-2 inhibitors (COX-2 inhibitors), also known as coxibs, are a type of nonsteroidal anti-inflammatory drug (NSAID) that directly target cyclooxygenase-2...

using selective COX-2 inhibitors. Arachidonic acid Cyclooxygenase Cyclooxygenase 1 Cyclooxygenase 2 NSAID COX-2 selective inhibitor Marnett, L. J.; Kalgutkar...

Cyclooxygenase-2 (COX-2), also known as prostaglandin-endoperoxide synthase 2 (HUGO PTGS2), is an enzyme that in humans is encoded by the PTGS2 gene....

carcinoma Cyclooxygenase-1 Cyclooxygenase-2 Cyclooxygenase-3 (not functional in humans) Discovery and development of COX-2 selective inhibitors PDB: 1CQE​;...

anti-inflammatory drug (NSAID), acting specifically as a relatively selective cyclooxygenase-2 inhibitor. However, the pharmacological profile of nimesulide is peculiar...

their introduction in 1948. NSAIDs work by inhibiting the activity of cyclooxygenase enzymes (the COX-1 and COX-2 isoenzymes). In cells, these enzymes are...

the "Use of the nonselective NSAID diclofenac and the selective cyclooxygenase-2 inhibitor rofecoxib was associated with an increased risk of cardiovascular...

lowering blood pressure. As a result of inhibiting the ACE enzyme in the bradykinin system, the ACE inhibitor drugs allow for increased levels of bradykinin...

Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). It is used to treat...

and most recently discovered cyclooxygenase (COX3050) isozyme, while the first two to be discovered were COX-1 and COX-2. The COX-3 isozyme is encoded...

painful menstruation and menstrual symptoms. It is a selective cyclooxygenase-2 inhibitor. It was patented in 1995. Valdecoxib was manufactured and marketed...

Arachidonic acid Cyclooxygenase Cyclooxygenase 2 NSAID Discovery and development of COX-2 selective inhibitors COX-2 selective inhibitor GRCh38: Ensembl...

Kleindienst N, Möller HJ, Arolt V, Riedel M (July 2006). "The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results...

A, Cerovecki A, Goldstein-Müller B, et al. (July 2006). "The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results...

2008). "Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man". FASEB Journal. 22 (2): 383–90. doi:10.1096/fj.07-8506com. PMID 17884974...

NF-κB [58]. Another important activity for hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase [59]. Moreover, this species attenuated...

MF, Silberstein SD (2002). "Hemicrania continua responds to cyclooxygenase-2 inhibitors". Headache. 42 (6): 530–1. doi:10.1046/j.1526-4610.2002.02131...

A TNF inhibitor is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor (TNF), which is part of the inflammatory response...

inhibits types 1 and 2 (IC50Tooltip half-maximal inhibitory concentration = 8.5 nM), but also 3β-HSDTooltip 3β-hydroxysteroid dehydrogenase inhibitor...

inhibiting the production of prostaglandins, endogenous signaling molecules known to cause these symptoms. It does this by inhibiting cyclooxygenase,...

reversed once the glucocorticoids therapy is stopped. As NSAIDs inhibit cyclooxygenase, the production of thromboxane, a natural coagulator, is inhibited...

NF-κB [58]. Another important activity for hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase [59]. Moreover, this species attenuated...

A. (2002). Evaluation of Preoperative Administration of the Cyclooxygenase-2 Inhibitor Rofecoxib for the Treatment of Postoperative Pain after Lumbar...

inhibition the substrate and inhibitor cannot bind to the enzyme at the same time.: 134  This usually results from the inhibitor having an affinity for the...

inhibitor binds to the active site where it is modified by the enzyme to produce a reactive group that reacts irreversibly to form a stable inhibitor-enzyme...

FitzGerald GA, Skarke C (October 2013). "GCG100649, A Novel Cyclooxygenase-2 Inhibitor, Exhibits a Drug Disposition Profile in Healthy Volunteers Compatible...

NS-398 is a COX-2 inhibitor used in the study of the function of cyclooxygenases. Celecoxib Tilmacoxib (JTE-522) "N194 NS-398". Sigma-Aldrich. Retrieved...

prostaglandin antagonists are: NSAIDs (inhibit cyclooxygenase) and COX-2 selective inhibitors or coxibs Corticosteroids (inhibit phospholipase A2 production) Cyclopentenone...

molecular cloning, signal ... Ito Y (2003). "Effects of selective cyclooxygenase inhibitors on ischemia/reperfusion-induced hepatic microcirculatory dysfunction...

PMID 12237248. White, WB (2007). "Cardiovascular effects of the cyclooxygenase inhibitors". Hypertension. 49 (3): 408–418. doi:10.1161/01.HYP.0000258106...