Fulvestrant, sold under the brand name Faslodex among others, is an antiestrogenic medication used to treat hormone receptor (HR)-positive metastatic...
27 KB (2,341 words) - 12:46, 12 September 2024
ZB716 (redirect from Fulvestrant-3 boronic acid)
ZB716, also known as fulvestrant-3-boronic acid, is a synthetic, steroidal, orally active antiestrogen which is under development for the treatment of...
5 KB (334 words) - 03:23, 12 January 2024
factor receptor 2-negative breast cancer when used in combination with fulvestrant. The US Food and Drug Administration (FDA) considers it to be a first-in-class...
12 KB (725 words) - 15:37, 8 September 2024
suppressing tumor growth. A common SERD used in clinical practice is fulvestrant. Fulvestrant is administered as an intramuscular injection and is indicated...
6 KB (530 words) - 16:44, 28 August 2024
used to treat certain types of breast cancer. It is used together with fulvestrant. It is taken by mouth. It is marketed by Novartis. Common side effects...
15 KB (958 words) - 05:40, 18 July 2024
palbociclib is prescribed as a combination therapy with either letrozole or fulvestrant. Patients should also not consume CYP3A inhibitors or inducers while...
37 KB (3,558 words) - 20:55, 20 August 2024
alters a patient's hormones". In studies that compared fulvestrant plus abemaciclib to fulvestrant plus placebo in breast cancer patients, progression-free...
18 KB (1,467 words) - 23:44, 20 August 2024
ER silent antagonist and selective estrogen receptor degrader (SERD) fulvestrant, aromatase inhibitors (AIs) like anastrozole, and antigonadotropins including...
8 KB (745 words) - 06:15, 3 September 2024
choice of endocrine therapy. The choices for the control arm included fulvestrant, or an aromatase inhibitor. Randomization was stratified based on whether...
13 KB (917 words) - 16:30, 28 August 2024
phase III trials BELLE-2 and BELLE-3 comparing buparlisib + fulvestrant with fulvestrant alone in patients with breast cancer both showed excessive side...
45 KB (5,359 words) - 22:07, 19 July 2024
clinical trials: The phase III trial BELLE-2 compared buparlisib + fulvestrant with fulvestrant alone in patients with advanced or metastatic HER2-negative,...
8 KB (690 words) - 22:44, 5 August 2024
October 2024. Inavolisib is indicated in combination with palbociclib and fulvestrant for the treatment of adults with endocrine-resistant, PIK3CA-mutated...
21 KB (1,851 words) - 00:15, 12 October 2024
loading dose include digoxin, teicoplanin, voriconazole, procainamide and fulvestrant. One or series of doses that may be given at the onset of therapy with...
4 KB (507 words) - 17:27, 21 October 2023
combination with an aromatase inhibitor as initial endocrine-based therapy; or fulvestrant as initial endocrine-based therapy or following disease progression on...
17 KB (1,497 words) - 07:59, 1 July 2024
Antihormone therapy (section Fulvestrant (Faslodex))
tamoxifen is no longer effective. Fulvestrant is a SERD drug that acts by damaging and blocking estrogen receptors. Fulvestrant is currently only approved by...
11 KB (1,058 words) - 15:08, 21 July 2024
bazedoxifene Antiestrogens (ER antagonists) Examples: fulvestrant, ICI-164384, TAS-108 (SR-16234), ZB716 (fulvestrant-3-boronic acid), ethamoxytriphetol (MER-25)...
5 KB (357 words) - 23:19, 9 May 2024
cancer. In China, dalpiciclib is approved for use in combination with fulvestrant for treatment of HR-positive, HER2-negative recurrent, or metastatic...
4 KB (141 words) - 22:46, 5 August 2024
Leuprorelin and bicalutamide L02BA01 Tamoxifen L02BA02 Toremifene L02BA03 Fulvestrant L02BA04 Elacestrant L02BB01 Flutamide L02BB02 Nilutamide L02BB03 Bicalutamide...
2 KB (239 words) - 00:26, 31 December 2023
failed previous hormonal therapies (tamoxifen, aromatase inhibitors, and fulvestrant). The prodrug tamoxifen is metabolized by the CYP2D6 enzyme to produce...
15 KB (1,428 words) - 02:41, 6 July 2024
raloxifene, tamoxifen and toremifene are banned. Clomiphene, cyclofenil, fulvestrant, and all other anti-estrogenic substances are banned. Myostatin inhibitors...
20 KB (1,821 words) - 22:04, 12 September 2024
Chloroindazole Cytestrol acetate EM-800 (SCH-57050) Epitiostanol ERA-90 ERB-88 Fulvestrant (ICI-182780) Glyceollins (I, II, III, IV) ICI-164384 MDL-101906 Mepitiostane...
28 KB (2,425 words) - 13:01, 4 October 2024
Chloroindazole Cytestrol acetate EM-800 (SCH-57050) Epitiostanol ERA-90 ERB-88 Fulvestrant (ICI-182780) Glyceollins (I, II, III, IV) ICI-164384 MDL-101906 Mepitiostane...
26 KB (2,467 words) - 14:07, 12 September 2024
pathway. The receptor is insensitive to the antiestrogen ICI-182,780 (fulvestrant). ERx GPER (GPR30) Gq-mER Estrogen receptor Toran-Allerand CD, Guan X...
2 KB (178 words) - 06:31, 2 November 2023
Chloroindazole Cytestrol acetate EM-800 (SCH-57050) Epitiostanol ERA-90 ERB-88 Fulvestrant (ICI-182780) Glyceollins (I, II, III, IV) ICI-164384 MDL-101906 Mepitiostane...
41 KB (3,914 words) - 10:47, 25 September 2024
Chloroindazole Cytestrol acetate EM-800 (SCH-57050) Epitiostanol ERA-90 ERB-88 Fulvestrant (ICI-182780) Glyceollins (I, II, III, IV) ICI-164384 MDL-101906 Mepitiostane...
67 KB (6,821 words) - 20:22, 2 August 2024
options include those used in localized cancer, plus toremifene and fulvestrant, often used in combination with CDK4/6 inhibitors (palbociclib, ribociclib...
134 KB (15,174 words) - 09:32, 7 October 2024
Chloroindazole Cytestrol acetate EM-800 (SCH-57050) Epitiostanol ERA-90 ERB-88 Fulvestrant (ICI-182780) Glyceollins (I, II, III, IV) ICI-164384 MDL-101906 Mepitiostane...
149 KB (15,702 words) - 15:45, 11 October 2024
and a synthetic derivative of estradiol which is closely related to fulvestrant and was never marketed. It is a silent antagonist of the estrogen receptor...
4 KB (188 words) - 15:38, 1 March 2024
Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol Goserelin Isosorbide mononitrate...
79 KB (6,427 words) - 19:30, 7 October 2024
Disufenton sodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrronium bromide/formoterol Goserelin Isosorbide mononitrate...
42 KB (3,798 words) - 03:37, 17 September 2024