Interferon-stimulated gene 15 (ISG15) is a 17 kDA secreted protein that in humans is encoded by the ISG15 gene. ISG15 is induced by type I interferon (IFN)...
22 KB (2,575 words) - 06:16, 1 January 2024
the deubiquitinating protease family of enzymes. It is known to remove ISG15 conjugates from a broad range of protein substrates, a process known as...
18 KB (1,884 words) - 05:57, 26 April 2022
cross-reactive protein (UCRP, also known as interferon-stimulated gene-15 ISG15), ubiquitin-related modifier-1 (URM1), neuronal-precursor-cell-expressed...
98 KB (11,068 words) - 18:25, 16 July 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
15 KB (1,741 words) - 18:05, 31 December 2023
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
29 KB (3,499 words) - 07:16, 20 February 2024
(2005). "Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme". J. Biochem....
6 KB (752 words) - 06:02, 5 January 2024
covalent linkage to the Nedd protein ISGylation, the covalent linkage to the ISG15 protein (Interferon-Stimulated Gene 15) pupylation, the covalent linkage...
33 KB (3,189 words) - 03:12, 28 March 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
49 KB (5,533 words) - 10:41, 19 July 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
24 KB (2,754 words) - 03:25, 27 May 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
10 KB (1,274 words) - 23:14, 6 February 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
13 KB (1,384 words) - 23:04, 9 June 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
22 KB (2,753 words) - 18:34, 26 March 2024
TRIM21 TRIM21 E3 ubiquitin-protein ligase TRIM21 TRIM25 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 TRIM56 TRIM56 E3 ubiquitin-protein ligase TRIM56 TRIM71 TRIM71...
183 KB (12,458 words) - 20:40, 1 July 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
51 KB (5,537 words) - 09:56, 13 June 2024
(June 2010). "The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15". Mol Cell. 38 (5):...
3 KB (405 words) - 05:52, 3 June 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
34 KB (3,955 words) - 22:16, 10 June 2024
regulating proteasome-mediated protein degradation through suppression of the ISG15 conjugation pathway". PLOS ONE. 6 (1): e16422. Bibcode:2011PLoSO...616422W...
80 KB (10,530 words) - 11:14, 15 July 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
50 KB (5,687 words) - 16:06, 10 July 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
52 KB (6,394 words) - 03:48, 19 March 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
2 KB (215 words) - 03:26, 28 March 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
27 KB (3,282 words) - 18:16, 8 June 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
76 KB (8,677 words) - 20:29, 22 July 2024
Interferon gamma receptor 2 deficiency Tyk2 deficiency JAK1 loss-of-function ISG15 deficiency RORc deficiency STAT1 deficiency, gain-of-function mutation STAT2...
19 KB (1,836 words) - 09:52, 5 July 2024
Zhao C, Denison C, Huibregtse JM, Gygi S, Krug RM (July 2005). "Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins...
23 KB (2,831 words) - 13:19, 24 May 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
18 KB (2,085 words) - 18:55, 25 April 2024
enzymes that remove the ubiquitin-like domain interferon-stimulated gene 15 (ISG15) from cellular proteins. These activities are likely responsible for antagonizing...
11 KB (1,085 words) - 13:29, 22 May 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
34 KB (4,104 words) - 21:30, 11 April 2024
SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic...
31 KB (3,521 words) - 04:06, 19 March 2024
HGNC:28660 Q9BUE6 7800 ISCA2 HGNC:19857 Q86U28 7801 ISCU HGNC:29882 Q9H1K1 7802 ISG15 HGNC:4053 P05161 7803 ISG20 HGNC:6130 Q96AZ6 7804 ISG20L2 HGNC:25745 Q9H9L3...
277 KB (17 words) - 15:46, 9 May 2024
Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene. The modification of proteins with ubiquitin is an...
7 KB (870 words) - 00:54, 4 March 2023