Ku80 is a protein that, in humans, is encoded by the XRCC5 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break...
21 KB (2,612 words) - 05:45, 11 June 2024
other). Eukaryotic Ku is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5), so named because the molecular weight of the human Ku proteins is...
15 KB (1,695 words) - 15:03, 17 January 2023
during mammalian NHEJ. Eukaryotic Ku is a heterodimer consisting of Ku70 and Ku80, and forms a complex with DNA-PKcs, which is present in mammals but absent...
28 KB (3,683 words) - 16:38, 29 October 2024
non-homologous end joining DNA repair pathway, including DNA-PKcs, Ku70/Ku80 and DNA ligase IV assembled with topo IIβ and PARP-1. This assemblage was...
57 KB (6,173 words) - 00:11, 11 December 2023
the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80, and DNA LIGASE IV) (see Figure). These enzymes repair the double-strand...
134 KB (16,677 words) - 23:04, 4 November 2024
DNA double-strand breaks as well as the level of the DNA repair protein Ku80. In a study of the cells from sixteen mammalian species, genes employed in...
222 KB (23,150 words) - 10:54, 2 November 2024
particular, mutant mice defective in Ku70, or Ku80, or double mutant mice deficient in both Ku70 and Ku80 exhibit early aging. The mean lifespans of the...
97 KB (11,101 words) - 11:45, 3 September 2024
recombinational repair BRCA1 30% homologous recombinational repair XRCC5 (Ku80) 20% nonhomologous end joining FEN1 100% hypomethylated (increased expression)...
51 KB (5,333 words) - 22:13, 7 September 2024
KP32 — May 24, 2001 Kitt Peak Spacewatch · 1.0 km MPC · JPL 640447 2001 KU80 — February 9, 2005 Kitt Peak Spacewatch · 2.4 km MPC · JPL 640448 2001 KV80...
179 KB (301 words) - 20:13, 1 August 2024
protein that, in humans, is encoded by the XRCC6 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and...
15 KB (1,689 words) - 09:17, 5 November 2024
initiated instead of NHEJ. In contrast, the presence of a Ku complex (Ku70 and Ku80) indicates that NHEJ has been initiated instead of HDR. HDR and NHEJ repair...
9 KB (1,265 words) - 11:50, 29 October 2024
interact with: ATM, C1D, and CDC5L, CHEK1, CHUK, CIB1, DCLRE1C, ILF2, ILF3, Ku80, NCOA6, P53, RPA2, and WRN. AZD7648, M3814 (peposertib), M9831 (VX-984) and...
32 KB (3,754 words) - 05:22, 30 September 2024
Telomerase reverse transcriptase has been shown to interact with: HSP90AA1, Ku70, Ku80, MCRS1, Nucleolin, PINX1, and YWHAQ. PAWR telomerase reverse transcriptase...
46 KB (5,304 words) - 20:19, 20 October 2024
the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see figure). These enzymes repair the double-strand breaks...
26 KB (2,839 words) - 06:27, 28 October 2024
strand breaks. In Co-Immunoprecipitation experiments, MRI-2 bound to Ku70 and Ku80, two subunits of Ku, which play a major role in the NHEJ pathway. MRI-3 GRCh38:...
2 KB (259 words) - 19:40, 13 April 2022
Hoeijmakers JH, Vijg J, van Steeg H, Hasty P (2014). "The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency". PLOS ONE. 9 (4): e93568...
42 KB (3,756 words) - 04:23, 25 March 2024
(XRCC6) and Ku80 (XRCC5)]. ETS1 interaction with DNA-PK phosphorylates ETS1. Such phosphorylation of ETS1 alters its target gene repertoire. The Ku80 portion...
13 KB (1,811 words) - 03:47, 21 August 2023
considered a transcription factor MCM3AP possibly a primase XRCC5 NM_021141 Ku80 XRCC6 NM_001469 Homo sapiens thyroid autoantigen: Single-stranded DNA-dependent...
48 KB (4,612 words) - 23:41, 12 December 2023
Ruan C, Workman JL, Simpson RT (October 2005). "The DNA repair protein yKu80 regulates the function of recombination enhancer during yeast mating type...
48 KB (5,814 words) - 16:09, 2 October 2024
present. Tyrosine kinase 2 has been shown to interact with FYN, PTPN6, IFNAR1, Ku80 and GNB2L1. GRCh38: Ensembl release 89: ENSG00000105397 – Ensembl, May 2017...
25 KB (2,850 words) - 23:00, 12 November 2023
with the aid of Cernunnos-XLF. DNA-PKcs and hXRCC4 are anchored to Ku70 / Ku80 heterodimer, which are bound to the DNA ends. Since hXRCC4 is the key protein...
43 KB (5,681 words) - 00:50, 14 June 2024
structure-specific endonuclease 1 GADD45A GADD45G HDAC1 HUS1 ING1 KCTD13 KIAA0101 Ku70 Ku80 MCL1 MSH3 MSH6 MUTYH P21 POLD2 POLD3 POLDIP2 POLH POLL RFC1 RFC2 RFC3 RFC4...
53 KB (6,158 words) - 18:54, 23 April 2024
(NHEJ) protein repairs double-stranded DNA breaks and relies on the Ku70/Ku80 heterodimer to function. Disrupting these proteins causes telomeric shortening...
16 KB (2,190 words) - 00:00, 27 July 2024
is a dimeric protein complex, a heterodimer of two polypeptides, Ku70 and Ku80. Ku protein forms a ring structure. An early step in non-homologous end joining...
18 KB (2,317 words) - 01:29, 3 December 2023
the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see Figure). These enzymes repair the double-strand breaks...
19 KB (2,287 words) - 10:45, 3 September 2024
ATP-dependent helicase has been shown to interact with: BLM DNA-PKcs, FEN1, Ku70, Ku80, P53, PCNA, TERF2, WRNIP1, RNF4,and PIAS4. GRCh38: Ensembl release 89: ENSG00000165392...
34 KB (4,157 words) - 13:23, 31 October 2024
"Cellular senescence and organismal ageing in the absence of p21 CIP1/WAF1 in ku80-/-mice". The EMBO Journal. 10 (1): 71–78. doi:10.1038/embor.2008.220. PMC 2613205...
16 KB (1,387 words) - 07:27, 31 May 2024
PMID 15232106. S2CID 20936301. Sibani S, Price GB, Zannis-Hadjopoulos M (May 2005). "Ku80 binds to human replication origins prior to the assembly of the ORC complex"...
9 KB (974 words) - 23:29, 3 March 2023
encoded by the KAT2A gene. GCN5L2 has been shown to interact with: DDB1, Ku70, Ku80, TADA2L, TAF9, and Transcription initiation protein SPT3 homolog. GRCh38:...
10 KB (1,168 words) - 02:48, 16 July 2024
showed that DDB2, in association with XRCC5 and XRCC6 (otherwise known as Ku80 and Ku70, which make up the Ku heterodimer), has transcriptional activities...
16 KB (2,071 words) - 18:17, 2 October 2024