LIN28 gene. LIN28 encodes an RNA-binding protein that binds to and enhances the translation of the IGF-2 (insulin-like growth factor 2) mRNA. Lin28 binds...
13 KB (1,537 words) - 04:55, 29 April 2024
pluripotent stem (iPS) cell reprogramming, LIN28 expression is reciprocal to that of mature let-7. LIN28 selectively binds the primary and precursor...
70 KB (8,221 words) - 23:58, 1 September 2024
as LIN28, and LEP and LEPR, which encode leptin and the leptin receptor, have been associated with precocious puberty. The association between LIN28 and...
41 KB (4,598 words) - 07:24, 19 September 2024
even allows some mammals (like mice) to heal wounds without scars. The LIN28 gene also plays a role in wound healing. It is dormant in most mammals....
12 KB (1,370 words) - 19:11, 17 July 2024
M510682200. PMID 16431920. Jun-Hao ET, Gupta RR, Shyh-Chang N (March 2016). "Lin28 and let-7 in the Metabolic Physiology of Aging". Trends in Endocrinology...
148 KB (16,818 words) - 04:03, 13 October 2024
and colleagues used a different set of factors, Oct4, Sox2, Nanog, and Lin28, using a lentiviral system. Obtaining fibroblasts to produce iPSCs involves...
92 KB (10,512 words) - 19:18, 10 October 2024
organ Biomedicine Cloning Induced pluripotent stem cell Life extension LIN28 Neuroregeneration Osteoarthritis#Research Polyphyodont Regeneration in humans...
33 KB (3,690 words) - 19:54, 16 September 2024
Wisconsin–Madison used a different set of factors, Oct4, Sox2, Nanog and Lin28, and carried out their experiments using cells from human foreskin. However...
99 KB (11,589 words) - 11:59, 19 August 2024
further identified uridylation-meditated pre-miRNA degradation pathway by LIN28 and TUT4, contributing to a better understanding of how microRNA-mediated...
23 KB (2,315 words) - 09:02, 13 September 2024
pluripotent-like stem cells (DPPSC). These cells are SSEA4+, OCT3/4+, NANOG+, SOX2+, LIN28+, CD13+, CD105+, CD34-, CD45-, CD90+, CD29+, CD73+, STRO1+, and CD146-,...
22 KB (2,474 words) - 16:59, 13 October 2024
magazine in 2008), and demonstration of the role of the RNA-binding protein Lin28 in cancer and metabolic disease. He has been elected a fellow of the American...
9 KB (970 words) - 15:07, 29 August 2024
human fibroblast cells to iPSCs via Oct-4, along with Sox2, Nanog, and Lin28. The use of Thomson reprogramming factors avoids the need to overexpress...
33 KB (3,818 words) - 23:33, 17 August 2024
EG (January 2007). "Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules". RNA Biology. 4 (1): 16–25...
183 KB (12,460 words) - 13:46, 23 September 2024
PMID 23063654. Thornton JE, Chang HM, Piskounova E, Gregory RI (October 2012). "Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11...
6 KB (718 words) - 00:39, 9 September 2024
Rao A, Lahesmaa R (March 2012). "RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer...
3 KB (401 words) - 12:54, 21 January 2024
used for reprogramming. Glis1 also up-regulates expression of the protein LIN28 which binds the let-7 microRNA precursor, preventing production of active...
17 KB (2,082 words) - 06:32, 25 July 2024
Heather A; Struhl, Kevin (2009-11-13). "An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation". Cell...
43 KB (4,611 words) - 01:12, 28 July 2024
2011). Horwitz MS (ed.). "Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility". PLOS...
6 KB (737 words) - 14:34, 3 December 2023