In biochemistry, a ligase is an enzyme that can catalyze the joining (ligation) of two molecules by forming a new chemical bond. This is typically via...
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DNA ligase is a type of enzyme that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond. It plays a role...
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A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin...
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List of EC numbers (EC 6) (redirect from Carbon-carbon ligases)
tyrosine—tRNA ligase EC 6.1.1.2: tryptophan—tRNA ligase EC 6.1.1.3: threonine—tRNA ligase EC 6.1.1.4: leucine—tRNA ligase EC 6.1.1.5: isoleucine—tRNA ligase EC 6...
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ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. The result of this sequential cascade is to bind ubiquitin...
98 KB (11,068 words) - 18:53, 17 August 2024
The RNA Ligase ribozyme was the first of several types of synthetic ribozymes produced by in vitro evolution and selection techniques. They are an important...
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Eukaryotic cells ligases belong to ATP type, and NAD+ - dependent are found in bacteria (e.g. E. coli). The discovery of DNA ligase dates back to 1967...
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The ligase chain reaction (LCR) is a method of DNA amplification. The ligase chain reaction (LCR) is an amplification process that differs from PCR in...
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Succinate—CoA ligase (ADP-forming) EC 6.2.1.6: Glutarate—CoA ligase EC 6.2.1.7: Cholate—CoA ligase EC 6.2.1.8: Oxalate—CoA ligase EC 6.2.1.9: Malate—CoA ligase EC...
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deoxyribonucleic ligase, deoxyribonucleic repair enzyme, deoxyribonucleic joinase, DNA ligase, deoxyribonucleate ligase, polynucleotide ligase, deoxyribonucleic...
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layer. Stage two involves four key Mur ligase enzymes: MurC, MurD, MurE (EC) and MurF (EC). These four Mur ligases are responsible for the successive additions...
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DNA ligase 1 also DNA ligase I, is an enzyme that in humans is encoded by the LIG1 gene. DNA ligase 1 is the only known eukaryotic DNA ligase involved...
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Glutamate–cysteine ligase (GCL) EC 6.3.2.2), previously known as γ-glutamylcysteine synthetase (GCS), is the first enzyme of the cellular glutathione (GSH)...
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Okazaki fragments (section DNA ligase I)
synthesized discontinuously and later linked together by the enzyme DNA ligase to create the lagging strand during DNA replication. They were discovered...
33 KB (4,435 words) - 14:24, 7 June 2024
Glutamine synthetase (redirect from Glutamate—ammonia ligase)
glutamate—ammonia ligase Active site between two monomers of glutamine synthetase from Salmonella typhimurium. Cation binding sites are yellow and orange;...
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UBE3A (redirect from Ubiquitin protein ligase E3A)
Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. This...
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Cholate—CoA ligase (EC 6.2.1.7, BAL, bile acid CoA ligase, bile acid coenzyme A ligase, choloyl-CoA synthetase, choloyl coenzyme A synthetase, cholic thiokinase...
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Parkin (protein) (redirect from Parkin (ligase))
Parkin is a 465-amino acid residue E3 ubiquitin ligase, a protein that in humans and mice is encoded by the PARK2 gene. Parkin plays a critical role in...
47 KB (5,731 words) - 11:29, 22 June 2024
Acetyl-CoA synthetase (redirect from Acetate—CoA ligase)
synthetase (ACS) or Acetate—CoA ligase is an enzyme (EC 6.2.1.1) involved in metabolism of acetate. It is in the ligase class of enzymes, meaning that...
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Lipoate–protein ligase (EC 2.7.7.63, LplA, lipoate protein ligase, lipoate–protein ligase A, LPL, LPL-B) is an enzyme with systematic name ATP:lipoate...
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Cullin (redirect from Cullin-RING ligases)
for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form Cullin-RING ubiquitin ligases (CRLs) that are...
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F420-0:L-glutamate ligase (EC 6.3.2.31, CofE-AF, MJ0768, CofE) is an enzyme with systematic name L-glutamate:coenzyme F420-0 ligase (GDP-forming). This...
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Heme ligase (EC 4.99.1.8, heme detoxification protein, HDP, hemozoin synthase) is an enzyme with systematic name Fe3+:ferriprotoporphyrin IX ligase (β-hematin-forming)...
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RTCB (redirect from RNA 2',3'-cyclic phosphate and 5'-OH ligase)
RNA 2',3'-cyclic phosphate and 5'-OH ligase is a protein that in humans is encoded by the RTCB gene. It is found in the stress granule of cells. As of...
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Mdm2 (section E3 ligase activity)
Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an...
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enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic...
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3-Hydroxybenzoate—CoA ligase (EC 6.2.1.37, 3-hydroxybenzoyl-CoA synthetase, 3-hydroxybenzoate-coenzyme A ligase (AMP-forming), 3-hydroxybenzoyl coenzyme...
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6-diaminopimelate ligase (EC 6.3.2.13, MurE synthetase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming),...
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DNA ligase 3 also DNA ligase III, is an enzyme that, in humans, is encoded by the LIG3 gene. LIG3 encodes ATP-dependent DNA ligases that seal interruptions...
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In enzymology, a UDP-N-acetylmuramoyl-L-alanine—D-glutamate ligase (EC 6.3.2.9) is an enzyme that catalyzes the chemical reaction ATP + UDP-N-acetylmuramoyl-L-alanine...
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