family involved in the degradation of the extracellular matrix. In humans the MMP9 gene encodes for a signal peptide, a propeptide, a catalytic domain with...
25 KB (3,114 words) - 13:32, 5 January 2024
concentrations show a significant increased cytotoxic activity and suppress COX-2 and MMP9 gene expression in both cell culture and colon tissue, suggest the anti-inflammatory...
15 KB (1,623 words) - 23:19, 24 March 2024
of ages 76 to 80 years. Epitalon appears to inhibit the synthesis of the MMP9 protein in vitro in aging skin fibroblasts. An in vivo study in aging mice...
16 KB (1,511 words) - 01:16, 19 November 2023
The hemopexin-like C-terminal domain of MMP9 PDB 1itv...
23 KB (2,312 words) - 20:35, 22 July 2024
beta, interleukin 6, tumor necrosis factor alpha (TNF alpha), MMP1, MMP2, MMP9, prostaglandin E2, complement system, reactive oxygen species (ROS), and...
36 KB (3,904 words) - 05:31, 2 September 2024
to aortic dissection and aneurysm. However, other studies have also shown MMP9 involvement with no differences in TIMP expression. The size of the proximal...
21 KB (2,392 words) - 19:10, 5 May 2024
PMC 6289486. PMID 30546844. Turner RJ, Sharp FR (2016-03-04). "Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following...
36 KB (3,981 words) - 09:39, 11 September 2024
collagen synthesis and fibrosis of the heart. Increase expression of MMP1 and MMP9 led to degradation of collagen fibres, and subsequently dilatation of the...
13 KB (1,504 words) - 16:02, 22 July 2024
of growth factors and are required for tumor metastasis and angiogenesis. MMP9 is associated with the bone microenvironment. It is expressed by osteoclasts...
26 KB (2,918 words) - 00:49, 26 August 2024
Additionally, in KRT81-knockdown MDA-MB231 cells, zymography illustrated decreased MMP9 activity, while scratch and invasion assays demonstrated diminished cell...
15 KB (1,833 words) - 11:57, 19 February 2024
active site zinc. Examples of enzymes that ilomastat inhibit include rabbit MMP9, thermolysin, peptide deformylase, and anthrax lethal factor endopeptidase...
6 KB (440 words) - 22:43, 2 September 2024
against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration into tumours...
11 KB (1,358 words) - 17:09, 6 September 2023
to be activated in a protease-dependent or independent manner. MMP2 and MMP9 are select TGF-β activators and ligands and are found in higher levels in...
29 KB (3,706 words) - 11:06, 2 September 2024
HGNC:7173 P08254 9660 MMP7 HGNC:7174 P09237 9661 MMP8 HGNC:7175 P22894 9662 MMP9 HGNC:7176 P14780 9663 MMP10 HGNC:7156 P09238 9664 MMP11 HGNC:7157 P24347...
277 KB (17 words) - 15:46, 9 May 2024
Baumann PS, Klauser P, Conus P, Tirouvanziam R, Cuenod M (November 2020). "MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation...
19 KB (2,337 words) - 03:47, 26 April 2024
Shimizu D, et al. (May 2011). "Ranpirnase Interferes with NF-κB Pathway and MMP9 Activity, Inhibiting Malignant Mesothelioma Cell Invasiveness and Xenograft...
11 KB (1,235 words) - 16:11, 7 August 2024
Oi Y, Milewicz DM (*Authors contribution equal). Association of MMP2 and MMP9 polymorphisms with intracranial aneurysms. J Neurosurg. 105(3):418-23, 2006...
7 KB (851 words) - 04:46, 5 August 2023
This resulted in cells being promoted to enter S phase more rapidly ROCK-1 MMP9: necessary for ECM regulation FMNL3: a Formin downstream target, which is...
16 KB (1,931 words) - 03:37, 17 June 2024
(February 2011). "Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic...
12 KB (1,744 words) - 04:07, 2 September 2024
expressed are matrix metalloproteinases MMP2 and MMP9. Additionally, gelatinases A (MMP2) and B (MMP9) have been proven to assist in developing new blood...
10 KB (1,248 words) - 19:26, 18 April 2024
phosphorylation. This can then trigger expression of matrix metalloproteinase 9 (MMP9). MMP9 can degrade proteins in the extracellular matrix, which aids in the priming...
15 KB (1,923 words) - 20:41, 6 July 2022
angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9). Along with its main oncogene function in hepatocellular carcinoma (HCC)...
12 KB (1,486 words) - 04:59, 29 July 2024
upregulating the expression of matrix metalloproteinases (MMPs) MMP2 and MMP9 in ovarian cancer. Contrary to previously mentioned cancers, the amount of...
14 KB (1,766 words) - 16:05, 25 July 2024
angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9). MTDH acts as an oncogene in melanoma, malignant glioma, breast cancer and...
16 KB (1,754 words) - 21:20, 5 July 2024
Lactoferrin, Lipoprotein lipase, LPL, MAPK8IP1, MAPK8IP2, Midkine, MMP13, MMP2, MMP9, Neuroserpin, Nexin-1, NOS1AP, PAI 2, PAI-1, PDGF, tPA, uPA, Polymyxin B...
32 KB (3,450 words) - 14:57, 7 September 2024
induction of prometastatic and angiogenic factors like CCL2, Cox-2, MMP2, MMP9 and VEGF. Furthermore mS100a7a15 recruits tumor-associated-macrophages (TAM)...
8 KB (914 words) - 19:40, 30 November 2023
MMP7 has a shallow hydrophobic substrate-binding pocket. In contrast to MMP9 which has the longest hinge, MMP7 lacks hemopexin and does not have a hinge...
17 KB (2,277 words) - 16:18, 5 April 2024
Ronkainen A, Juvonen T, Kuivaniemi H (Nov 1999). "Genetic analysis of MMP3, MMP9, and PAI-1 in Finnish patients with abdominal aortic or intracranial aneurysms"...
26 KB (3,031 words) - 10:50, 15 January 2024
this protein family) matrix metalloproteinases: MMP1, MMP2, MMP3, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13, MMP14, MMP15, MMP16, MMP17, MMP19, MMP20, MMP21...
4 KB (414 words) - 21:06, 6 July 2021
encoding proteins containing this domain include: MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP12, MMP13, MMP14, MMP15, MMP16, MMP17, MMP19, MMP20, MMP21, MMP24...
6 KB (674 words) - 11:03, 18 January 2022