A morphogen is a substance whose non-uniform distribution governs the pattern of tissue development in the process of morphogenesis or pattern formation...

flag model is a conceptual definition of a morphogen, described by Lewis Wolpert in the 1960s. A morphogen is defined as a signaling molecule that acts...

the neural tube), and later from the floor plate cells. Shh acts as a morphogen, meaning that it acts in a concentration-dependent manner to specify cell...

embryogenesis. Bicoid was the first protein demonstrated to act as a morphogen. Although bicoid is important for the development of Drosophila and other...

in early embryo development, exhibit a ratchet effect in response to morphogen concentrations. The low receptor occupancy permits increases in receptor...

(Dpp) is a key morphogen involved in the development of the fruit fly Drosophila melanogaster and is the first validated secreted morphogen. It is known...

chemical signal, a morphogen, resulting in the growth of a certain type of structure, say a darkly pigmented patch of skin. If the morphogen is present everywhere...

limbs, digits and many other parts of the body. Sonic hedgehog is a morphogen that patterns the developing embryo using a concentration gradient characterized...

Democratic Party for the People, a Japanese political party Decapentaplegic, a morphogen involved in development Diketopyrrolopyrrole dye, a class of organic dyes...

et al. (October 2000). "Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors". Science. 290 (5491):...

for the first time the presence and behavior of filopodia with a known morphogen signaling protein - decapentaplegic. Decapentaplegic is expressed in the...

morphogenesis. Morphogens are soluble molecules that can diffuse and carry signals that control cell differentiation via concentration gradients. Morphogens typically...

signaling molecules called morphogens that pattern uniform pools of cells in a concentration- and time-dependent manner. The morphogen sonic hedgehog (Shh)...

developing organisms without the classical requirement of diffusible morphogens. Studies in chick and mouse embryonic development suggest that the patterns...

mesenchymal compartment. Continued signaling by BMP, FGF, and RA, the morphogens that initially induced placode formation, collectively coordinate the...

environment and intercellular signaling. Thus, as individuals develop, morphogens activate or silence genes in an epigenetically heritable fashion, giving...

Antennapedia regulates the formation of anterior limbs in the embryo. Morphogens: These are molecules that form gradients in embryonic development and...

are a class of plant hormones (or plant-growth regulators) with some morphogen-like characteristics. Auxins play a cardinal role in coordination of many...

which the focus creates the morphogen, or by the sink model, in which the focus generates a gradient by removing a morphogen which was created elsewhere...

Netrin-1, a morphogen that will interact with the Deleted in Colorectal Cancer (DCC) receptor on growth cones of the RGC axon. This morphogen initially...

long-range transport of hydrophobic intercellular messengers, like the morphogen Indian hedgehog (protein). Nascent VLDL released from the liver contains...

the alar plate to develop sensory neurons. Opposing gradients of such morphogens as BMP and SHH form different domains of dividing cells along the dorsal...

(SHFM) locus, the large number of morphogens involved in limb development, the complex interactions between these morphogens, the involvement of modifier genes...

morphogen slope dependency on growth, highlighting importantly that her model could account for normal growth despite local variations in morphogen concentration...

candidates of epigenetic regulators of cellular differentiation. These morphogens are crucial for development, and include bone morphogenetic proteins,...

fate, and may even generate other morphogens that signal back to the original cell. Over longer distances morphogens may use the active process of signal...

200–204. doi:10.1016/0968-0004(87)90094-6. Rogers KW, Schier AF (2011). "Morphogen gradients: from generation to interpretation". Annual Review of Cell and...

it offered the best regeneration results. Lately, the introduction of morphogen-enhanced bone graft substitutes have shown similar success rates and quality...

excess RA was present. This then concludes that RA plays the role of a morphogen to identify proximal distal patterning of limb development in mice embryos...

Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has...