A myofibroblast is a cell phenotype that was first described as being in a state between a fibroblast and a smooth muscle cell. Myofibroblasts are contractile...

contraction is the myofibroblast, which is a specialized contractile fibroblast. These cells express α-smooth muscle actin (α-SMA). The myofibroblasts are absent...

occurs without myofibroblast involvement. Later, fibroblasts, stimulated by growth factors, differentiate into myofibroblasts. Myofibroblasts, which are similar...

and compliance, through complex coiling. It has been suggested that myofibroblasts also reside in the lamina propria of several organs. These cells have...

contribute to basal lamina components in some situations (e.g. subepithelial myofibroblasts in intestine may secrete the α-2 chain-carrying component of the laminin...

factors to generate myofibroblasts. Dysregulated transforming growth factor β (TGF-β) signalling in fibroblasts and myofibroblasts has been observed in...

This is a list of cells in humans derived from the three embryonic germ layers – ectoderm, mesoderm, and endoderm. Trichocyte Keratinocyte Gonadotrope...

profile to resemble various other cell types, including macrophages, myofibroblasts, mesenchymal stem cells and osteochondrocytes. Importantly, genetic...

becomes congested from engorged soft tissue. Elsewhere in the body, myofibroblasts of the nipple-areolar complex contract, causing erection of the nipples...

apoptosis. CAFs have been found to be abundant in a tumour stroma. Myofibroblasts and fibroblasts make up CAFs. The functions of these CAFs have been...

insults that cause inflammation can result in the cells transforming into myofibroblasts, resulting in collagen production, fibrosis, and cirrhosis. The Space...

activates resident Hepatic Stellate Cells (HSCs) into the fibrogenic myofibroblasts that are largely responsible for liver fibrosis. However, whereas TNF...

Saunders/Elsevier. ISBN 978-1-4377-0792-2. Shin D1, Minn KW. (2004). "The effect of myofibroblast on contracture of hypertrophic scar". Plast Reconstr Surg. 113 (2):...

hepatic stellate cell (HSC) activation, Kupffer cell activation, and myofibroblast activation. Normally, SECs generate nitric oxide, which has several...

infarction. Following injury, fibroblasts can become activated and turn into myofibroblasts – cells which exhibit behaviour somewhere between a fibroblast (generating...

2. spermatids 3. spermatocytes 4. spermatogonia 5. Sertoli cell 6. myofibroblasts 7. Leydig cells 8. capillaries Details System Reproductive system Location...

2 spermatids, 3 spermatocytes, 4 spermatogonia, 5 Sertoli cell, 6 myofibroblasts, 7 Leydig cells, 8 capillaries Identifiers MeSH D007985 FMA 72297 Anatomical...

such as ependymoma, glioblastoma and schwannoma. It may also stain myofibroblasts and smooth muscle cells. Furthermore, it may stain nodal epithelial...

as alpha-smooth muscle actin or α-SMA) is often used as a marker of myofibroblast formation. Studies have shown that ACTA2 is associated with TGF-β pathway...

2 spermatids, 3 spermatocytes, 4 spermatogonia, 5 Sertoli cell, 6 myofibroblasts, 7 Leydig cells, 8 capillaries Identifiers MeSH D013093 FMA 72291 Anatomical...

deliver signals to surrounding cells and have been shown to regulate myofibroblast differentiation. In melanoma, tumor-derived vesicles can enter lymphatics...

limits fibrosis during wound closure by inducing cell cycle arrest in myofibroblasts once they have fulfilled their function. When these cells have accomplished...

role in TGF-beta1 dependent fibroblast to myofibroblast differentiation. Aberrant persistence of myofibroblasts within tissues can lead to progressive tissue...

much stronger type I collagen. Some of the fibroblasts mature into myofibroblasts which contain the same type of actin found in smooth muscle, which enables...

in a variety of processes associated with heart failure, including myofibroblast proliferation, fibrogenesis, tissue repair, inflammation, and ventricular...

is characterized by faster resolution of inflammation and control of myofibroblast action compared to skin wounds in the red Duroc pig model". Journal...

Zhang X, Ziegler S, Perales-Patón J, et al. (January 2021). "Decoding myofibroblast origins in human kidney fibrosis". Nature. 589 (7841): 281–286. Bibcode:2021Natur...

new vessels at the zone of contact that is filled with pericytes and myofibroblasts. These cells begin laying collagen fibers into the core to provide an...

contributing to epithelial–mesenchymal transition, and potentially, to myofibroblast differentiation and proliferation. These discoveries suggest that DAMPs...

Phillips AO, Steadman R (May 2013). "TGF-β1-stimulated fibroblast to myofibroblast differentiation is mediated by HA-facilitated EGFR and CD44 co-localization...