O-linked glycosylation is the attachment of a sugar molecule to the oxygen atom of serine (Ser) or threonine (Thr) residues in a protein. O-glycosylation...

bypass glycosylation. Five classes of glycans are produced: N-linked glycans attached to a nitrogen of asparagine or arginine side-chains. N-linked glycosylation...

N-linked glycosylation is the attachment of an oligosaccharide, a carbohydrate consisting of several sugar molecules, sometimes also referred to as glycan...

participate in O-linked glycosylation are attached to threonine or serine on the hydroxyl group of the side chain. O-linked glycosylation occurs in the...

(O-linked), or histidine (N-linked) adenylylation, the addition of an adenylyl moiety, usually to tyrosine (O-linked), or histidine and lysine (N-linked)...

classical secretory glycosylation can be structurally essential. For example, inhibition of asparagine-linked, i.e. N-linked, glycosylation can prevent proper...

donors required for the synthesis of the lipid-linked oligosaccharide precursor of N-linked glycosylation. In 1998, Niehues described a new CDG syndrome...

this process and improve brain glucose metabolism. O-GlcNAc O-GlcNAcase (OGA) O-linked glycosylation GRCh38: Ensembl release 89: ENSG00000147162 – Ensembl...

O-GlcNAc differs from other forms of protein glycosylation: (i) O-GlcNAc is not elongated or modified to form more complex glycan structures, (ii) O-GlcNAc...

human O-GlcNAcase in complex with Thiamet-G identified the structural basis of enzyme inhibition. O-GlcNAc O-GlcNAc transferase O-linked glycosylation GRCh38:...

There are broadly two types of glycosylation, N-linked glycosylation and O-linked glycosylation. N-linked glycosylation starts in the endoplasmic reticulum...

or threonine is favourable for O-linked glycosylation. The first monosaccharide attached in the synthesis of O-linked glycans is N-acetyl-galactosamine...

sulfate which may modify core proteins through N-linked glycosylation or O-linked glycosylation of the proteoglycan Hyaluronic acid (also known as hyaluronan)...

nutrition. The glycoprotein nature of patatin, characterized by O-linked glycosylation, incorporates various monosaccharides, including fucose, indicating...

metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation". Proceedings of the National Academy of Sciences. 100 (25): 14846–14851...

Renfrow, Matthew B.; Dybvig, Kevin (2015-11-23). "General N-and O-Linked Glycosylation of Lipoproteins in Mycoplasmas and Role of Exogenous Oligosaccharide"...

: 51–2  They are usually glycoproteins, more commonly via N-linked than O-linked glycosylation.: 33  Spikes typically have a role in viral entry. They may...

polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus". J. Cell Sci. 111 (1): 45–60. doi:10...

threonine or tyrosine residues. Shown to the right are a number of predicted o-linked sites. None have been experimentally determined thus far.[when?] An alignment...

Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. They are also termed S-type lectins due to their dependency...

(Galβ1-3GalNAcα1-Ser/Thr) is a disaccharide that serves as a core 1 structure in O-linked glycosylation. First described by Thomsen as a red blood cell's antigen, later...

gonadotropin (CG) beta-subunit to the common alpha-subunit: retention of O-linked glycosylation and enhanced in vivo bioactivity of chimeric human CG". Molecular...

often modified in a particular way. Modifications may be N- or O- linked glycosylation, phosphorylation, tyrosine sulfation or other. "Reviews glossary"...

posttranslational modifications. The hydroxyl side-chain can undergo O-linked glycosylation. In addition, threonine residues undergo phosphorylation through...

humans. Mucin short variant S1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial...

first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated...

A chemical glycosylation reaction involves the coupling of a glycosyl donor, to a glycosyl acceptor forming a glycoside. If both the donor and acceptor...

sugar as in the case of N-linked glycosylation, or to a protein, as in the case of O-linked glycosylation produced by O-fucosyltransferase. There are...

addition one of the most intriguing aspects thereof is the capability of O-glycosylation to extend half life, decrease clearance, and improve PK/PD thereof...

O-linked glycosylation, are relocated from the Golgi to the ER. Activation of the pathway is thought to result in the alteration of the glycosylation...