• Protamines are small, arginine-rich, nuclear proteins that replace histones late in the haploid phase of spermatogenesis and are believed essential for...
    18 KB (2,042 words) - 23:50, 4 April 2024
  • Protamine sulfate is a medication that is used to reverse the effects of heparin. It is specifically used in heparin overdose, in low molecular weight...
    14 KB (1,419 words) - 18:49, 28 June 2024
  • Thumbnail for NPH insulin
    Neutral Protamine Hagedorn (NPH) insulin, also known as isophane insulin, is an intermediate-acting insulin given to help control blood sugar levels in...
    11 KB (905 words) - 23:37, 11 September 2024
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    prior exposure to protamine, such as those who have had a previous vasectomy (protamine is contained in sperm) or diabetics (protamine is contained in neutral...
    34 KB (4,040 words) - 09:37, 26 September 2024
  • be neutralized, protamine is used to neutralize heparin by binding to it. Animal and in vitro studies have demonstrated that protamine neutralizes the...
    27 KB (3,060 words) - 14:59, 21 August 2024
  • Thumbnail for Insulin aspart
    which contains 30% insulin aspart and 70% insulin aspart protamine. The insulin aspart protamine portion is a crystalline form of insulin aspart, which...
    24 KB (1,877 words) - 21:09, 21 September 2024
  • Thumbnail for Friedrich Miescher
    first scientist to isolate nucleic acid in 1869. Miescher also identified protamine and made several other discoveries. Miescher had isolated various phosphate-rich...
    13 KB (1,490 words) - 19:13, 27 May 2024
  • irritation. He came upon protamine, a protein isolated from fish sperm. Hagedorn discovered that the addition of protamine to insulin caused the insulin...
    3 KB (356 words) - 09:29, 4 July 2024
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    range. It is still used as an alternative to protamine sulfate for patients who are sensitive to protamine, and at least one surgical center has gone back...
    5 KB (447 words) - 10:47, 16 September 2024
  • subsequently themselves replaced by protamines. TNPs in humans include TNP1 and TNP2. Chromatin Histone Protamine Sperm Spermatogenesis Spermiogenesis...
    1 KB (85 words) - 02:12, 8 July 2022
  • Thumbnail for Serine/threonine-specific protein kinase
    was split into several entries (including 2.7.11.1) in 2005. 2.7.11.70 "protamine kinase" was merged into 2.7.11.1 in 2004. 2.7.11.- is the generic level...
    14 KB (1,210 words) - 13:35, 14 June 2024
  • Thumbnail for PRM1
    Protamine 1 is a protein that in humans is encoded by the PRM1 gene. GRCh38: Ensembl release 89: ENSG00000175646 – Ensembl, May 2017 "Human PubMed Reference:"...
    4 KB (449 words) - 10:47, 11 April 2024
  • Mogielnicki, Andrzej (2016). "The toxicology of heparin reversal with protamine: Past, present and future". Expert Opinion on Drug Metabolism & Toxicology...
    46 KB (5,032 words) - 09:46, 11 August 2024
  • Thumbnail for Insulin (medication)
    adding protamine to insulin prolongs the duration of action of insulin 1946 Nordisk formulates Isophane porcine insulin aka Neutral Protamine Hagedorn...
    108 KB (11,440 words) - 15:04, 26 September 2024
  • Thumbnail for RuBisCO
    efficient method for precipitating out RuBisCO involves the usage of protamine sulfate solution. Other existing methods for depleting RuBisCO and studying...
    59 KB (6,522 words) - 18:16, 20 August 2024
  • Thumbnail for Karyogamy
    Kar family of proteins, as well as a protamine, are required for the fusion of nuclear membranes. The protamine Prm3 is located on the outer surface of...
    19 KB (2,272 words) - 05:23, 25 October 2023
  • following cardiopulmonary bypass procedures where heparin is reversed using protamine intraoperatively. In instances where a patient develops bleeding due to...
    16 KB (2,008 words) - 16:59, 19 July 2024
  • NSAIDs. Other relatively common causes include chemotherapy, vaccines, protamine and herbal preparations. Some medications (vancomycin, morphine, x-ray...
    58 KB (6,226 words) - 03:59, 9 September 2024
  • Polyploidization Structures Telomere: Telomere-binding protein (TINF2) Protamine See also Extrachromosomal DNA Plasmid List of organisms by chromosome...
    19 KB (1,963 words) - 06:04, 2 October 2024
  • Heparin sodium Phytomenadione Protamine sulfate Tranexamic acid Warfarin Complementary: Desmopressinα Heparin sodiumα Protamine sulfateα Warfarinα Deferasirox...
    67 KB (4,835 words) - 05:59, 17 August 2024
  • Thumbnail for Testicle
    testis-specific proteins that show the highest level of expression are protamines. There are two phases in which the testes grow substantially. These are...
    61 KB (6,239 words) - 20:50, 22 August 2024
  • Thumbnail for Insulin
    B1 BOVINE INSULIN 2omg: Structure of human insulin cocrystallized with protamine and urea 2omh: Structure of human insulin cocrystallized with ARG-12 peptide...
    121 KB (13,799 words) - 18:31, 13 September 2024
  • Thumbnail for Transduction (genetics)
    have been used to improve transduction efficiency such as polybrene, protamine sulfate, retronectin, and DEAE Dextran. Gene therapy: Correcting genetic...
    12 KB (1,431 words) - 21:03, 1 July 2024
  • Thumbnail for Enoxaparin sodium
    case, anti-Xa units can be measured and dosing adjusted accordingly. Protamine sulfate is less effective at reversing enoxaparin compared to heparin...
    22 KB (1,681 words) - 21:53, 11 September 2024
  • Thumbnail for Insulin glargine
    which includes insulin glargine, do not appear much better than neutral protamine Hagedorn (NPH) insulin, but do have a greater cost, making them, as of...
    20 KB (1,637 words) - 08:06, 7 September 2024
  • Polyploidization Structures Telomere: Telomere-binding protein (TINF2) Protamine See also Extrachromosomal DNA Plasmid List of organisms by chromosome...
    8 KB (586 words) - 20:00, 24 October 2023
  • Thumbnail for Heparin
    liver disease, and stroke), severe liver disease, or severe hypertension. Protamine sulfate has been given to counteract the anticoagulant effect of heparin...
    77 KB (7,855 words) - 18:45, 29 August 2024
  • States in July 2021, and in the European Union in March 2018. NPH (Neutral Protamine Hagedorn) insulin is an intermediate-acting insulin with delayed absorption...
    22 KB (2,828 words) - 19:32, 20 December 2023
  • Thumbnail for PRM2
    Protamine 2 is a protein that in humans is encoded by the PRM2 gene. Protamines substitute for histones in the chromatin of sperm during the haploid phase...
    4 KB (570 words) - 20:37, 29 January 2023
  • Thumbnail for Epigenetics
    retained in sperm cells (where most but not all histones are replaced by protamines). Thus nucleosome positioning is to some degree inheritable. Recent studies...
    161 KB (18,346 words) - 02:11, 20 August 2024