molecular biology, protein fold classes are broad categories of protein tertiary structure topology. They describe groups of proteins that share similar...

Protein folding is the physical process by which a protein, after synthesis by a ribosome as a linear chain of amino acids, changes from an unstable random...

a protein. For simple proteins, it can be the entire protein. The broadest groups on SCOP version 1.75 are the protein fold classes. These classes group...

predict protein folding and thus protein structure, for example, Itasser, and AlphaFold. AlphaFold was one of the first AIs to predict protein structures....

heme-containing globular proteins, involved in binding and/or transporting oxygen. These proteins all incorporate the globin fold, a series of eight alpha...

are proteins that assist the conformational folding or unfolding of large proteins or macromolecular protein complexes. There are a number of classes of...

AlphaFold is an artificial intelligence (AI) program developed by DeepMind, a subsidiary of Alphabet, which performs predictions of protein structure....

proteins. There are multiple fold classes of globular proteins, since there are many different architectures that can fold into a roughly spherical shape...

finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) which stabilizes the fold. It was originally...

Small proteins are a diverse fold class of proteins (usually <100 amino acids long). Their tertiary structure is usually maintained by disulphide bridges...

The jelly roll or Swiss roll fold is a protein fold or supersecondary structure composed of eight beta strands arranged in two four-stranded sheets. The...

protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains...

assisting protein folding. HSP60 belong to a large class of molecules that assist protein folding, called molecular chaperones. Newly made proteins usually...

helix/beta sheet proteins. While most proteins adopt a single stable fold, a few proteins can rapidly interconvert between one or more folds. These are referred...

identified as a peptide, rather than a protein. To be able to perform their biological function, proteins fold into one or more specific spatial conformations...

In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest...

change can impact the protein's ability to function or to fold correctly. Misfolded proteins have a tendency to form dense protein clumps, which are often...

pathways within cells that control the biogenesis, folding, trafficking, and degradation of proteins present within and outside the cell. Loss of proteostasis...

transcription, translation, post translational modifications, and protein folding. Proteins are made from amino acids. In humans, some amino acids can be...

help of an MHC class I protein. Because MHC class I molecules present peptides derived from cytosolic proteins, the pathway of MHC class I presentation...

residues within proteins as they fold. This allows proteins to quickly find the correct arrangement of disulfide bonds in their fully folded state, and therefore...

transformer protein (TFP) also known as a metamorphic protein is a protein that can interconvert between two or more shapes (also known as folds) each having...

and its sequence (termed protein redesign). Rational protein design approaches make protein-sequence predictions that will fold to specific structures....

perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress. This...

The CATH Protein Structure Classification database is a free, publicly available online resource that provides information on the evolutionary relationships...

Chemical chaperones are a class of small molecules that function to enhance the folding and/or stability of proteins. Chemical chaperones are a broad and...

isomerase), also known as an alpha/beta barrel,: 252  is a conserved protein fold consisting of eight alpha helices (α-helices) and eight parallel beta...

proteins that assist other proteins in assuming their three-dimensional fold, which is necessary for protein function. However, the fold of a protein...

expression. The AAA proteins contain two domains, an N-terminal alpha/beta domain that binds and hydrolyzes nucleotides (a Rossmann fold) and a C-terminal...

classification notes that 20 distinct protein folds have phosphatase activity, and 10 of these contain protein phosphatases. The CC1 fold is the most common, and includes...