A pyrin domain (PYD, also known as PAAD/DAPIN) is a protein domain and a subclass of protein motif known as the death fold, the 4th and most recently discovered...
14 KB (1,163 words) - 13:27, 27 September 2024
NLRP3 (redirect from NACHT, LRR and PYD domains-containing protein 3)
NLR family pyrin domain containing 3 (NLRP3) (previously known as NACHT, LRR, and PYD domains-containing protein 3 [NALP3] and cryopyrin), is a protein...
17 KB (1,737 words) - 14:15, 4 June 2024
residues. Other motifs in this class include the pyrin domain (PYD), death domain (DD), and death effector domain (DED), all of which also function primarily...
15 KB (1,429 words) - 20:45, 30 May 2024
Inflammasome (section Pyrin inflammasome)
and pyrin. Through their caspase activation and recruitment domain (CARD) or pyrin domain (PYD), the inflammasome receptors interact with the adaptor...
71 KB (7,823 words) - 11:34, 29 July 2024
NLRP (Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing), also abbreviated as NALP, is a type of NOD-like receptor...
17 KB (2,056 words) - 15:22, 17 November 2023
Death fold (section PYRIN)
include the death domain (DD), death effector domain (DED), caspase recruitment domain (CARD), and pyrin domain (PYD). Death fold domains are an evolutionarily...
4 KB (481 words) - 20:44, 1 July 2024
types of death domain subfamilies: death effector domain (DED), caspase recruitment domain (CARD), pyrin domain (PYD), and death domain (DD). These subfamily...
20 KB (2,089 words) - 19:45, 16 August 2024
with other domains, such as the caspase recruitment domain (InterPro: IPR001315), the pyrin domain (InterPro: IPR004020), the HEAT repeat domain (InterPro: IPR004155)...
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NLR family pyrin domain containing 9 pseudogene 1 is a protein that in humans is encoded by the NLRP9P1 gene. "Human PubMed Reference:". National Center...
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and it can consist of caspase recruitment domain (CARD), pyrin domain (PYD), acidic transactivating domain or baculovirus inhibitor repeats (BIRs). Names...
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interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members...
10 KB (1,338 words) - 23:55, 12 April 2024
recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif...
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Mediterranean fever gene, which encodes a 781–amino acid protein called pyrin. While all ethnic groups are susceptible to FMF, it usually occurs in people...
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effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily and the pyrin domain (PYD) subfamily. These proteins are evolutionarily conserved...
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gene. NALP proteins, such as NALP2, are characterized by an N-terminal pyrin domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678)...
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oligomerization domain-like receptor (NLR) pyrin domain (PYD)-containing protein 12 (NLRP12; also known as NACHT, LRR and PYD domains-containing protein...
21 KB (2,187 words) - 22:56, 10 September 2024
NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known...
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Syndrome Caused by a Mutation in the Nucleotide-Binding Domain, Leucine-Rich Repeat Family, Pyrin Domain-Containing 3 (NLRP3) Gene". American Journal of Ophthalmology...
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as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich...
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NOD-like receptor family pyrin domain containing 11 is a protein that in humans is encoded by the NLRP11 gene located on the long arm of human chromosome...
11 KB (1,271 words) - 10:33, 12 December 2023
(ATP) and uric acid, which are purine metabolites, activate NLR family, pyrin domain containing (NLRP) 3 inflammasomes to induce IL-1β and IL-18. DAMPs in...
36 KB (3,641 words) - 12:47, 1 October 2024
Autoinflammatory diseases (section Pyrin)
(nucleotide-binding oligomerization domain (NOD)-like receptors), pyrin, or NLRC4 (NOD-like receptors (NLR) Family CARD Domain Containing 4). Inflammasomes are...
18 KB (2,089 words) - 03:51, 28 September 2024
production of IL-1β and IL-18. NLRP3 (contains three domain: pyrin domain, a nucleotide-binding domain and a leucine-rich repeat) type of inflammasome is...
26 KB (3,273 words) - 13:58, 26 August 2024
superfamily (other recognizable domains in this superfamily are: caspase-recruitment domain (CARD), pyrin domain (PYD) and death domain (DD)). The subfamilies...
20 KB (2,410 words) - 06:29, 3 June 2024
such as NALP7, have an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich...
5 KB (647 words) - 04:54, 12 August 2024
(OLT1177) is an inhibitor of the NLRP3 (nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3) inflammasome. An inflammasome...
26 KB (2,161 words) - 09:36, 23 July 2024
leucine-rich repeat (LRR) domains, a central nucleotide-binding and oligomerization domain (NBD) and an N-terminal pyrin domain (PYD). NLRP3, for example...
35 KB (3,948 words) - 06:00, 10 June 2024
NLRP10, short for NOD-like receptor family pyrin domain containing 10, is an intracellular protein of mammals that functions in apoptosis and the immune...
4 KB (586 words) - 02:53, 12 August 2024
family pyrin domain containing 13, is an intracellular protein of mammals. It is also known as NALP13, NOD14, PAN13, and CLR19.7, and is one of 14 pyrin domain...
1 KB (180 words) - 03:44, 17 April 2022