factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that in humans is encoded by the RUNX2 gene. RUNX2 is a key...
19 KB (2,246 words) - 22:36, 11 April 2024
inherited in an autosomal dominant manner. It is due to a defect in the RUNX2 gene which is involved in bone formation. Diagnosis is suspected based on...
19 KB (1,675 words) - 04:56, 19 October 2024
genes that control this craniofacial development. Of these genes, DCHS2, RUNX2, GLI3, PAX1 and PAX3 were found to determine nasal morphology, whereas EDAR...
5 KB (421 words) - 00:13, 12 September 2023
of: a non-DNA-binding CBFβ chain (CBFB) a DNA-binding CBFα chain (RUNX1, RUNX2, RUNX3) de Bruijn M, Speck N (2004). "Core-binding factors in hematopoiesis...
774 bytes (87 words) - 18:04, 28 November 2023
Chen JY, Chiang CL, Ng YY, Chen SJ (April 2010). "Exclusion of MYF5, GSC, RUNX2, and TCOF1 mutation in a case of cerebro-costo-mandibular syndrome". Clinical...
10 KB (876 words) - 16:45, 29 January 2023
RUNX1 ENSG00000159216 Runt Known motif – In vivo/Misc source [787] VACCACAV RUNX2 ENSG00000124813 Runt Known motif – High-throughput in vitro [788] HRACCRCADWAACCRCAV...
374 KB (81 words) - 02:10, 23 September 2023
among bone-forming vertebrate species It plays a major role, along with Runx2 and Dlx5 in driving the differentiation of mesenchymal precursor cells into...
24 KB (2,875 words) - 03:59, 22 March 2024
Runx2 signalling pathways. TGF-β will act as a stimulator of chondrogenesis, and an inhibitor of osteoblastic differentiation, by blocking the Runx2 factor...
14 KB (1,481 words) - 14:26, 29 July 2024
characterised by the identification of a heterozygous pathogenic variant in RUNX2 (CBFA1) and/or various clinical presentations and radiographs. There is...
22 KB (2,659 words) - 02:17, 1 December 2023
route of differentiation to osteoblast, rather than chondrocyte via the Runx2 gene expression. Potential therapeutic application in aiding bone degenerative...
25 KB (2,072 words) - 00:37, 4 October 2024
Chondroblast, formation. This factor is also expressed alongside Sox5 and Sox6. Runx2 is another important genetic component of Chondroblast formation. It has...
13 KB (1,528 words) - 22:20, 23 March 2024
dysplasia, but this is an autosomal dominant disease caused by mutations in the RUNX2 gene – and such mutations have not been found in Crane–Heise cases. Chromosomal...
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action. For example, length changes in tandemly repeating regions in the Runx2 gene lead to differences in facial length in domesticated dogs (Canis familiaris)...
67 KB (7,394 words) - 16:46, 2 September 2024
developing progenitor cells express the regulatory transcription factor Cbfa1/Runx2. A second required transcription factor is Sp7 transcription factor....
34 KB (3,988 words) - 13:53, 18 October 2024
with: BCL3, COBRA1, CSNK2A1, CSNK2A2, DDIT3, JUN NCOA1, NCOR2, RELA, RUNX1, RUNX2, SMAD3, and TBP. Leptomycin c-Jun Egr-1 Ion channel G proteins & linked...
26 KB (3,991 words) - 05:29, 10 July 2024
et al. (19 May 2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications....
32 KB (3,221 words) - 23:01, 5 October 2024
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1...
87 KB (9,390 words) - 08:13, 25 October 2024
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1...
37 KB (4,035 words) - 09:01, 19 August 2024
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1...
12 KB (1,317 words) - 20:08, 28 August 2023
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1...
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Chondrodysplasia, Grebe type GDF5 autosomal recessive Cleidocranial dysostosis RUNX2 1:7,800 Cockayne syndrome ERCC6, ERCC8 1:2,600-3,900 Coffin–Lowry syndrome...
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TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1...
57 KB (6,672 words) - 01:42, 9 October 2024
V, et al. (May 2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications....
26 KB (2,676 words) - 06:58, 15 August 2024
S, et al. (April 2008). "Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells". Gene. 413...
16 KB (1,936 words) - 20:50, 10 October 2024
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1...
42 KB (4,879 words) - 13:27, 9 October 2024
TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1...
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DM, Kong PZ, Sun Y, Liu PF, Wang QS, Feng YM (August 2015). "ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating...
3 KB (481 words) - 06:07, 9 October 2024
of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically...
9 KB (1,195 words) - 02:01, 23 December 2023
Mostly cytoplasm heart, liver, kidney, placenta α-Tubulin, HSP90, SHP, SMAD7 RUNX2 – HDAC10 1 Mostly cytoplasm liver, spleen, kidney – – – III sirtuins in...
31 KB (3,181 words) - 07:12, 12 August 2024
activated, YAP and TAZ can bind to several transcription factors including p73, Runx2 and several TEADs. YAP regulates the expression of Hoxa1 and Hoxc13 in mouse...
28 KB (3,241 words) - 14:19, 10 October 2024