Serpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms...
137 KB (14,301 words) - 12:53, 10 September 2024
Serpin A12 (OL-64, Vaspin, Visceral adipose-specific serpin, Ser A12) is a glycoprotein that is a class A member of the serine protease inhibitor (serpin)...
9 KB (1,122 words) - 19:31, 25 May 2024
displays sequence and three-dimensional homology to the serpin superfamily, but unlike most serpins it is not a serine protease inhibitor. The function of...
6 KB (662 words) - 20:07, 26 April 2024
inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor (serpin E1) is a protein that in humans is encoded by the SERPINE1 gene. Elevated...
13 KB (1,603 words) - 02:15, 10 March 2024
α1-antitrypsin (A1AT, α1AT, A1A, or AAT) is a protein belonging to the serpin superfamily. It is encoded in humans by the SERPINA1 gene. A protease inhibitor...
33 KB (3,383 words) - 08:00, 21 August 2024
Uterine serpins are members of the A clade of the serine protease inhibitor (serpin) superfamily of proteins and are encoded by the SERPINA14 gene. Uterine...
14 KB (1,518 words) - 16:46, 26 July 2024
(C1-inh, C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. Its main function is the inhibition of the complement system...
22 KB (2,216 words) - 19:56, 30 August 2024
Maspin (section Serpin superfamily)
in humans is encoded by the SERPINB5 gene. This protein belongs to the serpin (serine protease inhibitor) superfamily. SERPINB5 was originally reported...
14 KB (1,702 words) - 03:02, 16 July 2024
Transcortin, also known as corticosteroid-binding globulin (CBG) or serpin A6, is a protein produced in the liver in animals. In humans it is encoded by...
12 KB (1,420 words) - 01:37, 10 March 2024
member of the serpin family of proteins, leading to another name: Serpin A8, although it is not known to inhibit other enzymes like most serpins. In addition...
28 KB (3,125 words) - 22:38, 10 August 2024
(or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin. Plasmin is an important enzyme that...
11 KB (1,337 words) - 00:12, 20 December 2023
states that are not the expected most stable state. For example, many serpins (serine protease inhibitors) show this metastability. They undergo a conformational...
15 KB (1,603 words) - 16:54, 15 June 2024
A1AC, or a1ACT) is an alpha globulin glycoprotein that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene. Alpha 1-antichymotrypsin...
4 KB (475 words) - 00:52, 10 September 2024
haptoglobin. Others give negative feedback on the inflammatory response, e.g. serpins. Alpha 2-macroglobulin and coagulation factors affect coagulation, mainly...
11 KB (1,096 words) - 14:00, 24 December 2023
albumins: Ovalbumin is a storage protein in egg white (albumen). It is a serpin. Lactalbumin, or whey protein, is a protein fraction of milk. It is mainly...
12 KB (1,123 words) - 20:52, 29 October 2023
kinetic vs thermodynamic control of protein folding. Antithrombin is a serpin (serine protease inhibitor) and is thus similar in structure to most other...
46 KB (5,418 words) - 12:45, 29 August 2024
Serpin is a village in the Çorum District of Çorum Province in Turkey. Its population is 127 (2022). Köy, Turkey Civil Administration Departments Inventory...
1 KB (50 words) - 19:37, 14 February 2024
trypsin inhibitor (TI) is a protein and a type of serine protease inhibitor (serpin) that reduces the biological activity of trypsin by controlling the activation...
11 KB (1,305 words) - 02:13, 14 August 2024
serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins or ov-serpins (ovalbumin related serpins)...
9 KB (1,148 words) - 17:04, 26 July 2024
kallikrein, another process inhibited by C1INH. This serine protease inhibitor (serpin) normally inhibits the association of C1r and C1s with C1q to prevent the...
26 KB (3,008 words) - 06:59, 14 September 2024
apoptosis through caspase 8. Serpins generally inhibit serine proteases by a suicide substrate inhibition mechanism, in which the serpin undergoes a drastic change...
13 KB (1,572 words) - 12:11, 13 September 2024
primarily in the liver as a 54-kDa protein. In terms of genomics, TBG is a serpin; however, it has no inhibitory function like many other members of this...
10 KB (1,421 words) - 01:42, 26 August 2024
Pigment epithelium-derived factor (PEDF) also known as serpin F1 (SERPINF1), is a multifunctional secreted protein that has anti-angiogenic, anti-tumorigenic...
23 KB (2,742 words) - 21:03, 11 December 2023
keratoderma Peeling skin syndrome 5 is caused by a genetic defect in the serpin (serpin family member 8) gene. This gene is produced by platelets and can bind...
10 KB (1,110 words) - 13:34, 28 May 2024
Plasminogen activator inhibitor-2 (placental PAI, SerpinB2, PAI-2), a serine protease inhibitor of the serpin superfamily, is a coagulation factor that inactivates...
23 KB (2,909 words) - 16:49, 26 July 2024
erythroid nuclear termination stage-specific protein (MENT) is a member of the serpin family of protease inhibitors, and participates in DNA and chromatin condensation...
2 KB (186 words) - 05:56, 12 December 2020
to a thrombotic tendency. Antithrombin is a serine protease inhibitor (serpin) that degrades the serine proteases: thrombin, FIXa, FXa, FXIa, and FXIIa...
67 KB (6,817 words) - 22:55, 7 August 2024
Serpin B3 is a protein that in humans is encoded by the SERPINB3 gene. Serpin GRCh38: Ensembl release 89: ENSG00000057149 – Ensembl, May 2017 GRCm38:...
8 KB (1,015 words) - 04:08, 19 August 2024
Yeqing; Fan, Chunxin; Liang, Yujun; Gao, Bei; Zhang, Shicui (2012). "A novel serpin with antithrombin-like activity in Branchiostoma japonicum: Implications...
86 KB (10,225 words) - 11:45, 23 August 2024
protein Z-dependent protease inhibitor (ZPI), a serine protease inhibitor (serpin). The affinity of this protein for factor Xa is increased 1000-fold by the...
27 KB (3,353 words) - 09:39, 12 August 2024