Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's membrane. They belong to the superfamily...

Voltage-gated sodium channels (VGSCs), also known as voltage-dependent sodium channels (VDSCs), are a group of voltage-gated ion channels found in the...

Sodium channel blockers are drugs which impair the conduction of sodium ions (Na+) through sodium channels. The following naturally-produced substances...

A sodium channel opener is a type of drug which facilitates ion transmission through sodium channels. Examples include toxins, such as aconitine, veratridine...

epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that is selectively permeable to sodium ions...

voltage-gated ion channels directionally propagate electrical signals. Voltage-gated ion-channels are usually ion-specific, and channels specific to sodium (Na+)...

of the sodium channels and are equally large. Cation channels of sperm: This small family of channels, normally referred to as Catsper channels, is related...

concentration of sodium ions outside the cell than inside. In nerve cells, the sudden flow of sodium ions into the cell through voltage-gated sodium channels enables...

this is known as depolarization and is mainly due to the opening of sodium channels that allow Na+ to flow into the cell. After a delay (known as the absolute...

plasma membrane to reverse, and the ion channels then rapidly inactivate. As the sodium channels close, sodium ions can no longer enter the neuron, and...

The most commonly involved gene is SCN5A which encodes the cardiac sodium channel. Diagnosis is typically by electrocardiogram (ECG), however, the abnormalities...

either channels or carriers (a.k.a. transporters, or permeases). Examples of channel/carrier proteins include the GLUT 1 uniporter, sodium channels, and...

from the four channel subunits [1]. It may seem counterintuitive that a channel should allow potassium ions but not the smaller sodium ions through. However...

selective Nav1.7 blocker Cenobamate (YKP-3089) – atypical voltage-gated sodium channel blocker.: 5593–5605  DSP-2230 – selective Nav1.7 and Nav1.8 blocker...

type of voltage-gated sodium channel that underlies action potentials—these are sometimes called Hodgkin-Huxley sodium channels because they were initially...

of the transmembrane sodium channel protein. A mutation this gene will cause an individual to develop dysfunctional sodium channel Nav 1.1, which is crucial...

Sodium voltage-gated channel alpha subunit 9 (also Nav1.7) is a sodium ion channel that, in humans, is encoded by the SCN9A gene. It is usually expressed...

corresponds to the influx of sodium ions, whereas the two decays ("1" and "3", respectively) correspond to the sodium-channel inactivation and the repolarizing...

A variety of alpha subunit voltage-gated sodium channels have been identified. Voltage-gated sodium channels found in mammals can be divided into three...

heart to stop suddenly, known as respiratory arrest and cardiac arrest. Sodium channel blockers, like benzocaine, lidocaine, phenytoin, and tricaine methanesulfonate...

Martinez-Lavin M (February 2012). "A SCN9A gene-encoded dorsal root ganglia sodium channel polymorphism associated with severe fibromyalgia". BMC Musculoskeletal...

Valproate (valproic acid, VPA, sodium valproate, and valproate semisodium forms) are medications primarily used to treat epilepsy and bipolar disorder...

NaV1.6, a specific type of sodium channel, is responsible for the increased speed in transmission. NaV1.2, another sodium channel expressed in the axons and...

binding results in a sodium-ion channel that stays open longer. Aconitine suppresses the conformational change in the sodium-ion channel from the active state...

group 1B), voltage-gated sodium channel modulators (3A), nicotinic acetylcholine receptor modulators (5), chloride channel activators (6), midgut membrane...

Sodium channel protein type 5 subunit alpha, also known as NaV1.5 is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel...

stabilized by certain channel pores, such as a sodium ion attempting to pass through a potassium channel. In both cases, channel flux is not permitted...

subunits of the Epithelial sodium (Na+) channel (ENaC). These studies also helped establish that ENaC is the principal channel involved in blood volume...

Primary erythromelalgia is caused by mutation of the voltage-gated sodium channel α-subunit gene SCN9A. In 2004 erythromelalgia became the first human...

biological electric current contributed by non-inactivating voltage-gated sodium channels (NaVs) found in several central neurons. INaP has been implicated in...