Taxanes are a class of diterpenes. They were originally identified from plants of the genus Taxus (yews), and feature a taxadiene core. Paclitaxel (Taxol)...

(mBC) in patients who have been treated previously with trastuzumab and a taxane (paclitaxel or docetaxel), and who have already been treated for mBC or...

In enzymology, a taxane 13alpha-hydroxylase (EC 1.14.13.77) is an enzyme that catalyzes the chemical reaction taxa-4(20),11-dien-5alpha-ol + NADPH + H+...

agents include taxanes and epothilones, both of which prevent cancer cells from dividing by interfering with tubulin. While taxanes like Paclitaxel and...

In enzymology, a taxane 10beta-hydroxylase (EC 1.14.13.76) is an enzyme that catalyzes the chemical reaction taxa-4(20),11-dien-5alpha-yl acetate + NADPH...

liver problems. Use during pregnancy may harm the baby. Docetaxel is in the taxane family of medications. It works by disrupting the normal function of microtubules...

and include important compounds such as retinol, phytol or taxadiene. Taxanes are class of diterpenoids featuring a taxadiene core. They are produced...

paclitaxel or docetaxel. The core carbon skeleton of a normal natural product taxane (e.g., paclitaxel, docetaxel) has a 6-membered A ring, 8-membered B ring...

Taxamairin A is a non-taxane isolate of Taxus yunnanensis. Li SH, Zhan HJ, Yao P, Niu XM, Xiang W, Sun HD (2002). "Non-taxane compounds from the bark...

that use during pregnancy may cause birth defects. Paclitaxel is in the taxane family of medications. It works by interference with the normal function...

as the plant is a source of the class of poisonous chemicals known as taxanes, which have been a focus for cancer research. T. canadensis is much more...

permanently in a state of assembly and disassembly. Vinca alkaloids and taxanes are the two main groups of anti-microtubule agents, and although both of...

derivative of a natural taxoid. It is a microtubule inhibitor, and the fourth taxane to be approved as a cancer therapy.[citation needed] Cabazitaxel was developed...

unresectable, and/or metastatic breast cancer who received prior trastuzumab and taxane therapy for metastatic disease or developed disease recurrence during or...

advanced or metastatic breast cancer as a single agent if an anthracycline- or taxane-containing chemotherapy is not indicated; treatment of people with advanced...

showed it did not prevent CIPN and appeared to worsen the conditions in taxane therapy. Male infertility: Scientific reviews from 2016 and 2014 showed...

breast cancer, taxane-containing chemotherapy regimens appear to improve survival and tumour shrinkage and decrease time to progression. Taxanes are associated...

molecules have generated significant interest after the introduction of the taxanes into clinical oncology and the general use of the vinca alkaloids. Examples...

drugs that can alter microtubule dynamics include: The cancer-fighting taxane class of drugs (paclitaxel (taxol) and docetaxel) block dynamic instability...

epirubicin), antimetabolites (fluorouracil, capecitabine, and methotrexate), taxanes (docetaxel and paclitaxel), and platinum-based chemotherapies (cisplatin...

Gradishar WJ (June 2006). "Albumin-bound paclitaxel: a next-generation taxane". Expert Opinion on Pharmacotherapy. 7 (8): 1041–1053. doi:10.1517/14656566...

Tumors that evolve resistance to docetaxel may receive the second-generation taxane drug cabazitaxel. Some CRPC treatments are used only in men whose tumors...

gadolinium-containing radiocontrast. Bleomycin (a chemotherapeutic agent) and possibly taxane chemotherapy may cause scleroderma, and occupational exposure to solvents...

Vincristine# Vindesine Vinflunine§ Vinorelbine#) Block microtubule disassembly Taxanes (Cabazitaxel Docetaxel# Larotaxel Ortataxel† Paclitaxel# Tesetaxel) Epothilones...

Pavlakis N, Davey R (December 2007). "A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship" (PDF). Cancer...

Vincristine# Vindesine Vinflunine§ Vinorelbine#) Block microtubule disassembly Taxanes (Cabazitaxel Docetaxel# Larotaxel Ortataxel† Paclitaxel# Tesetaxel) Epothilones...

Vincristine# Vindesine Vinflunine§ Vinorelbine#) Block microtubule disassembly Taxanes (Cabazitaxel Docetaxel# Larotaxel Ortataxel† Paclitaxel# Tesetaxel) Epothilones...

marine sources, a controversial programme that led to the discovery of taxanes (in 1964) and camptothecins (in 1966). Both classes of drug were isolated...

AC-T may refer to: Adriamycin, cyclophosphamide, and a taxane, a combination chemotherapy regimen used to treat breast cancer Albert City–Truesdale Community...

Vincristine# Vindesine Vinflunine§ Vinorelbine#) Block microtubule disassembly Taxanes (Cabazitaxel Docetaxel# Larotaxel Ortataxel† Paclitaxel# Tesetaxel) Epothilones...