5α-Reductase 2 deficiency (5αR2D) is an autosomal recessive condition caused by a mutation in SRD5A2, a gene encoding the enzyme 5α-reductase type 2 (5αR2)...
39 KB (4,200 words) - 23:24, 16 June 2024
5α-Reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. They participate in three metabolic pathways:...
37 KB (4,017 words) - 05:49, 17 June 2024
Dihydrotestosterone (redirect from 5α-Dihydrotestosterone)
congenital 5α-reductase type 2 deficiency, an intersex condition caused by a loss-of-function mutation in the gene encoding 5α-reductase type 2, the major...
67 KB (6,821 words) - 14:50, 18 March 2024
SRD5A2 (redirect from 5α reductase type 2)
encodes the 3-oxo-5α-steroid 4-dehydrogenase 2 enzyme, also known as 5α-reductase type 2 (5αR2), one of three isozymes of 5α-reductase. 5αR2 catalyzes the...
8 KB (1,048 words) - 03:21, 8 November 2023
Later reports disclosed that Semenya has the intersex condition 5α-Reductase 2 deficiency and natural testosterone levels in the typical male range. In...
80 KB (6,183 words) - 05:28, 28 June 2024
and associated with prune belly syndrome. Observed in 5α-reductase 2 deficiency in which impaired 5α-dihydrotestosterone (DHT) synthesis impairs prostate...
1 KB (130 words) - 23:53, 19 July 2023
reported that four elite women athletes with XY chromosomes and 5α-reductase 2 deficiency were subjected to sterilization and "partial clitoridectomies"...
152 KB (14,237 words) - 14:53, 10 July 2024
"Gender Change in 46,XY Persons with 5α-Reductase-2 Deficiency and 17β-Hydroxysteroid Dehydrogenase-3 Deficiency". Archives of Sexual Behavior. 34 (4):...
19 KB (1,397 words) - 00:08, 26 June 2024
Androgen insensitivity syndrome (redirect from DHTR deficiency)
dehydrogenase 2 deficiency 17α-hydroxylase deficiency 17,20 lyase deficiency 17β-hydroxysteroid dehydrogenase deficiency 5α-reductase deficiency Androgen excess...
128 KB (12,638 words) - 06:36, 12 July 2024
testis are generally partially undescended. This also occurs with 5α-Reductase 2 deficiency (DHT insensitivity) however, the testis generally descend during...
36 KB (4,498 words) - 15:29, 1 July 2024
Congenital 5α-reductase 2 deficiency is a rare intersex condition which is associated with ambiguous genitalia in male fetuses due to a deficiency in DHT...
98 KB (11,326 words) - 04:15, 29 April 2024
SRD5A1 (redirect from 5α reductase I)
3-Oxo-5α-steroid 4-dehydrogenase 1 is an enzyme that in humans is encoded by the SRD5A1 gene. It is one of three forms of steroid 5α-reductase. Steroid 5α-reductase...
17 KB (1,870 words) - 02:33, 8 March 2024
Congenital adrenal hyperplasia (redirect from Congenital adrenal hyperplasia type 2)
errors of steroid metabolism Intersex List of vaginal anomalies 5α-Reductase 2 deficiency Androgen insensitivity syndrome El-Maouche D, Arlt W, Merke DP...
45 KB (4,574 words) - 07:07, 11 June 2024
conditions such as complete androgen insensitivity syndrome. In 5α-Reductase 2 deficiency, individuals are born with normal female genitalia, however, during...
23 KB (2,174 words) - 11:17, 13 July 2024
Finasteride (category 5α-Reductase inhibitors)
exposure by acting specifically on hair follicles. Finasteride is a 5α-reductase inhibitor and therefore an antiandrogen. It works by decreasing the production...
74 KB (7,440 words) - 13:20, 12 July 2024
5α-Reductase 2 deficiency: prevents the conversion of testosterone to dihydrotestosterone; causes androgen deficiency in males Aromatase deficiency:...
9 KB (720 words) - 22:08, 23 April 2024
Androgen backdoor pathway (section 5α-DHP subpathway)
by the enzyme 5α-reductase, primarily in tissues like the prostate gland, hair follicles, and skin. Both pathways rely on 5α-reductase, but in the androgen...
79 KB (8,729 words) - 02:51, 24 May 2024
Dutasteride (category 5α-Reductase inhibitors)
is due to its antiandrogenic effects similar to what is seen in 5α-reductase deficiency. For the same reason, women who are currently pregnant should never...
51 KB (4,969 words) - 10:16, 1 July 2024
androgen receptor antagonists, antigonadotropins, GnRH modulators, and 5α-reductase inhibitors to further oppose the effects of androgens like testosterone;...
232 KB (24,963 words) - 19:31, 12 July 2024
20-lyase deficiency, 5α-reductase deficiency), androgen insensitivity syndromes, inadequate pituitary stimulation (gonadotropin deficiency), and other...
9 KB (972 words) - 01:46, 2 June 2024
MK-386 (category 5α-Reductase inhibitors)
MK-386, also known as 4,7β-dimethyl-4-aza-5α-cholestan-3-one, is a synthetic, steroidal 5α-reductase inhibitor which was first reported in 1994 and was...
10 KB (956 words) - 20:22, 9 December 2023
either directly exert effects on target tissues or be metabolized by 5α-reductase into dihydrotestosterone (DHT) or aromatized to estradiol (E2). Both...
150 KB (15,741 words) - 10:52, 27 June 2024
relative to testosterone. Mesterolone is not a substrate for 5α-reductase, as it is already 5α-reduced, and hence is not potentiated in so-called "androgenic"...
23 KB (2,061 words) - 17:44, 8 March 2024
Smith–Lemli–Opitz syndrome (redirect from 7-dehydrocholesterol reductase deficiency)
Shackleton, Cedric (2004). "The implications of 7-dehydrosterol-7-reductase deficiency (Smith–Lemli–Opitz syndrome) to neurosteroid production". Steroids...
56 KB (6,560 words) - 23:49, 7 July 2024
5α-Pregnan-17α-ol-3,20-dione, also known as 17α-hydroxy-dihydroprogesterone (17‐OH-DHP) is an endogenous steroid, a metabolite of 17α-hydroxyprogesterone...
11 KB (1,041 words) - 22:30, 10 April 2024
in severe forms, due to aromatase deficiency in the placenta. Androgen backdoor pathway Cytochrome P450 reductase Flück, Christa E.; Pandey, Amit V....
6 KB (525 words) - 15:46, 10 December 2023
male pattern hair loss. Males with congenital 5α-reductase type 2 deficiency (but functional 5α-reductase type 1) never develop male-pattern hair loss...
59 KB (7,731 words) - 20:31, 8 May 2024
symptoms, medications may include alpha blockers such as terazosin or 5α-reductase inhibitors such as finasteride. Surgical removal of part of the prostate...
76 KB (7,869 words) - 08:04, 23 June 2024
the model is the rare condition congenital 5α-reductase type 2 deficiency, in which the 5α-reductase type 2 enzyme is defective, production of DHT is impaired...
210 KB (21,566 words) - 02:01, 10 July 2024
other AAS, which are either potentiated by 5α-reductase in such tissues or are not substrates of 5α-reductase. Antiandrogens like cyproterone acetate, spironolactone...
48 KB (4,805 words) - 03:53, 13 June 2024