Amylin, or islet amyloid polypeptide (IAPP), is a 37-residue peptide hormone. It is co-secreted with insulin from the pancreatic β-cells in the ratio of...

The amylin receptors (AMYRs) are heterodimers of the calcitonin receptor that are bound to by amylin with high affinity and consist of AMY1, AMY2, and...

Amylin Pharmaceuticals, Inc. is a biopharmaceutical founded in 1987 that was based in San Diego, California. The company was engaged in the discovery,...

Dual amylin and calcitonin receptor agonists (DACRAs) are a class of drugs that act as agonists at the amylin receptor and calcitonin receptor that are...

Cagrilintide is a long-acting analogue of amylin. It is being tested to treat obesity and type 2 diabetes by itself and in combination with semaglutide...

of Langerhans responsible for the production and release of insulin and amylin. Constituting ~50–70% of cells in human islets, beta cells play a vital...

(trade name Symlin) is an injectable amylin analogue drug for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals (now a wholly owned subsidiary...

Lilly might beat Amylin to a license. When Eng arrived at Amylin's San Diego headquarters, he was astonished to discover how much Amylin scientists had...

Cagrilintide/semaglutide, marketed as CagriSema, is a combination of cagrilintide, a dual amylin and calcitonin receptor agonist, and semaglutide, a GLP-1 agonist. It is...

diabetes. CCL2 induces amylin expression through ERK1/ERK2/JNK-AP1 and NF-κB related signaling pathways independent of CCR2. Amylin upregulation by CCL2...

multimeric amylin receptors AMY1 (CT + RAMP1), AMY2 (CT + RAMP2), and AMY3 (CT+ RAMP3). Preclinical studies have suggested that dual amylin and calcitonin...

Petrelintide (development name ZP8396) is an amylin analogue dosed once weekly, developed by Zealand Pharma for the treatment of type 2 diabetes and obesity...

patients aged 65 or older who received 12.5 or 25 mg/d of the medication. Amylin agonist analogues slow gastric emptying and suppress glucagon. They have...

amylin, a peptide hormone co-secreted with insulin from the pancreatic β cells. As plasma glucose levels recede, the subsequent reduction in amylin secretion...

In molecular biology, the amylin protein family or calcitonin/CGRP/IAPP protein family is a family of proteins, which includes the precursors of calcitonin/calcitonin...

by an intracrine mechanism. Adrenocorticotropic hormone (ACTH) Adropin Amylin Angiotensin Atrial natriuretic peptide (ANP) Calcitonin Cholecystokinin...

Incorporated in March 2021, 100% owned by Biocon. In 2009, Biocon and Amylin Pharmaceuticals of the United States entered into an agreement to develop...

a member of the calcitonin family of peptides consisting of calcitonin, amylin, adrenomedullin, adrenomedullin 2 (intermedin) and calcitonin‑receptor‑stimulating...

tirzepatide, are also agonists of the GIP receptor, glucagon receptor, and/or amylin receptor. These additional targets are hoped to improve the amount of weight...

with fewer adverse effects, but none have received approval as of 2023. Amylin analogues can both reduce energy intake and increase expenditure and can...

acquisition of the biotechnology company Amylin Pharmaceuticals. It was agreed that Bristol Myers Squibb would acquire Amylin for $5.3 billion in cash and the...

Amycretin is a single molecule that operates as a GLP-1 receptor agonist and amylin receptor agonist. It is under development by Novo Nordisk as a weight loss...

Rosiglitazone Troglitazone‡ Dual PPAR agonists Aleglitazar† Muraglitazar§ Saroglitazar Tesaglitazar§ Amylin analogs and DACRAs Cagrilintide§ Pramlintide...

Calcitonin Thyroid axis Parathyroid PTH Gonadal axis Pancreas Glucagon Insulin Amylin Somatostatin Pancreatic polypeptide Pineal gland Melatonin N,N-Dimethyltryptamine...

(POMC) peptides Enkephalin pentapeptides Prodynorphin peptides Calcitonin Amylin AGG01 Aromatic short peptides Biomimetic peptides Peptide amphiphiles Peptide...

sequence can induce or prevent self-assembly. For example, humans produce amylin, an amyloidogenic peptide associated with type II diabetes, but in rats...

Pharmaceuticals Accelrys / Biovia (acquired by Dassault Systems) Allerca Amylin Pharmaceuticals Apricus Biosciences Arena Pharmaceuticals Cytori Therapeutics...

when it agreed to buy Amylin Pharmaceuticals for around US$5.3 billion in cash and pay US$1.7 billion to Eli Lilly to cover Amylin's debt and its outstanding...

James T. Kadonaga is an American biologist, currently the Amylin Endowed Chair in Lifesciences at University of California, San Diego. Kadonga has a bachelor's...

Rosiglitazone Troglitazone‡ Dual PPAR agonists Aleglitazar† Muraglitazar§ Saroglitazar Tesaglitazar§ Amylin analogs and DACRAs Cagrilintide§ Pramlintide...