in a pathway to ensure that each cell accurately replicates its DNA and segregates it equally between the two daughter cells. One CDK–the CDK7 complex–cannot...

Cyclin H, GTF2H1, MNAT1, P53, SUPT5H, and XPB. Cyclin-dependent kinase CDK7 pathway ENSG00000277273 GRCh38: Ensembl release 89: ENSG00000134058, ENSG00000277273...

transcription. CDK1, CDK2, CDK3, CDK4, CDK6, and CDK7 are directly related to the regulation of cell-cycle events, while CDK7 – 11 are associated with transcriptional...

increasingly adopted by the community of scientists working on the mTOR pathway to refer to the protein and in homage to the original discovery of the...

GTF2H5/TTDA) form the core complex. The cyclin-activating kinase-subcomplex (CDK7, MAT1, and cyclin H) is linked to the core via the XPD protein. Two of the...

base excision repair (BER), and DNA mismatch repair (MMR). While the BER pathway can recognize specific non-bulky lesions in DNA, it can correct only damaged...

also play a role in T cell differentiation and the cellular apoptosis pathway. Activation occurs through a dual phosphorylation of threonine (Thr) and...

physically interact with Rheb. Thus the amino acid pathway as well as the growth factor/energy pathway converge on endosomes and lysosomes. Thus the Ragulator-Rag...

protects against viral infections. It also has a role in several signaling pathways. Protein kinase-R is activated by double-stranded RNA (dsRNA), introduced...

(mTOR) PI3K/AKT/mTOR pathway Akt/PKB signaling pathway PI3K inhibitor Pópulo H, Lopes JM, Soares P (2012). "The mTOR signalling pathway in human cancer"....

polymerase II. He also studied the function of another cdk complex, cyclin H/Cdk7, and its role in the initiation of zygotic transcription during the early...

2018). "Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models". Cell. 175 (1): 171–185.e25. doi:10...

and trichothiodystrophy. XPB has been shown to interact with: BCR gene, CDK7, ERCC2, GTF2H1, GTF2H2, GTF2H4, GTF2H5, P53, PSMC5, and XPC. Potent, bioactive...

protein-coupled receptors, transforming agents, and carcinogens, activate the ERK pathway.[citation needed] The term, "extracellular signal-regulated kinases", is...

Toyoshima K, et al. (June 1998). "Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin...

and apoptosis. The duration and intensity of signals determine which pathway ensues. Additionally, the use of protein scaffolds helps to place the MAPKKK...

protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway". J. Biol. Chem. 274 (19): 13271–80. doi:10.1074/jbc.274.19.13271. PMID 10224087...

transcriptional activator kappa B (NFκB) signaling pathway, Hedgehog signaling pathway, Notch signaling pathway, and epithelial-mesenchymal transition. Due to...

involved in cellular survival pathways, by inhibiting apoptotic processes. Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling...

BRE, CEBPZ, CDC14A, Cdk1, CFLAR, CHEK1, CCNG1, CREBBP, CREB1, Cyclin H, CDK7, DNA-PKcs, E4F1, EFEMP2, EIF2AK2, ELL, EP300, ERCC6, GNL3, GPS2, GSK3B, HSP90AA1...

humans is encoded by the RAF1 gene. The c-Raf protein is part of the ERK1/2 pathway as a MAP kinase (MAP3K) that functions downstream of the Ras subfamily...

complex. TFIIH is a large protein complex that contains among others the CDK7/cyclin H kinase complex and a DNA helicase. TFIIH has three functions: It...

downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway. As the name suggests, its target substrate is the S6 ribosomal protein...

of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in the IKBKG gene results in incontinentia pigmenti, hypohidrotic...

NF-κB-independent pathways such as oxidative stress and receptor-interacting protein kinase 1 (RIPK1) kinase activity-dependent pathway. In response to...

many signaling pathways and forms a node between them. For this reason, regulation of its involvement in individual signaling pathways is necessary. This...

molecules released by signaling pathways during pathogenic attack. IRAK-1 is classified as a kinase enzyme, which regulates pathways in both innate and adaptive...

MAP kinase family and as such a part of mitogen-activated protein kinase pathway. It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein...

which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. IKK's activity causes activation...

differentiation, apoptosis and autophagy. Persistent activation of the p38 MAPK pathway in muscle satellite cells (muscle stem cells) due to ageing, impairs muscle...